In the painting process of the industries such as automotive, metalworking, woodworkingand construction different kind of chemicals are used. Some of them producevolatile organic compounds (VOC) and cause adverse effects on human health, whichare related to the degree of toxicity of the chemical and the time of exposure. The targetwas describe the hierarchy of controls that were performed against chemical hazardsrelated to exposure to volatile organic compounds, in order to advice stakeholders inthe implementation of measures at individual and work environment that lead to thesafe handling and counteract the adverse effects from the use of VOCs. The methodologywas based on collecting and analyzing information from Industrial Hygiene andHealth at work of organizations such as American Conference of Industrial Hygienists,National Institute for Occupational Safety and Health, Occupational Safety and HealthAdministration, International Agency for Research on Cancer, American NationalStandards Institute, among others. The result of this research identified 107 chemicalsas the main components of the products used in the painting process. Among them 59are VOC, 12 are in groups 1 and 2 of International Agency for Research on Cancer, 24have TLV below 100 ppm and 19 are on that value, therefore, controls of substitution,engineering and administrative interventions are required.