There has been an increase in allegations of human rights violations in Latin America linked to the transnational activity of mining companies. To date, the legal treatment of these violations has been structured around the “effective” exercise of state jurisdiction and the attribution of international responsibility to the host States of transnational companies, in the absence of a binding treaty on corporate responsibility. However, this attribution is insufficient because, based on the lack of territorial jurisdiction, it leaves aside the international responsibility of the States of origin of transnational companies. Based on a critical, normative, doctrinal, and case-law analysis of the Inter-American System of Human Rights, this article suggests that the lack of jurisdiction exception should not be appropriate between States that belong to the same protection system of human rights. We argue that, in the interest of cooperation, universality, and the expansive nature of rights, member States of the same protection system are responsible internationally when their actions or omissions vis-à-vis transnational corporations are insufficient to avoid extraterritorial damage in human rights matters.