This paper analyzes the causes of forgetfulness that has been a constant in the Colombian Amazon and the implications that it has had on the border and foreign policy in the country. It also argues that taking part of a group of global, regional and national transformations, ACTO has been revitalized, which can be the first step to expand the State’s institutions on the Amazon territory, the starting point to taking advantage of its strategic potential, and to create synergies with other countries that are part of the Organization to confront a set of threats that defying the rainforest. In addition, the agency can be a vector of South American integration that eventually, could be quite receptive to leadership of Colombia.