TY - JOUR
AU - Cano Macias, Ricardo
AU - Jiménez Moscoso, José Alfredo
AU - Ruiz Vera, Jorge Mauricio
PY - 2023/03/08
Y2 - 2024/09/12
TI - One-compartment stochastic pharmacokinetic model
JF - Universitas Scientiarum
JA - Universitas Scientiarum
VL - 28
IS - 1
SE - Mathematics and Statistics
DO - 10.11144/Javeriana.SC281.ocsp
UR - https://revistas.javeriana.edu.co/index.php/scientarium/article/view/34271
SP - 23-41
AB - <p>In this work, we consider a pharmacokinetic (PK) model with first-order drug absorption and first-order elimination that represent the concentration of drugs in the body, including both the absorption and elimination parts, and we also add a random factor to describe the variability between patients and the environment. Using Itô’s lemma and the Laplace transform, we obtain the solutions in integral form for a single and constant dosage regimen in time. Moreover, formulas for the expected value and the variance for each case of study are presented, which allows the statistical assessment of the proposed models, as well as predicting the ideal path of drug concentration and its uncertainty. These results are important in the long-term analysis of drug concentration and the persistence of therapeutic level. Further, a numerical method for the solution of the stochastic differential equation (SDE) is introduced<br />and developed.</p>
ER -