Publicado feb 6, 2017



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Adriana Patricia Rojas Moreno

Ricardo Elias Bruges

Alejandra Cañas Arboleda

Luis Fernando Jaramillo García

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Resumen

En el mundo, el cáncer de pulmón es la principal causa de muerte por neoplasias, y
ello se debe a que su detección ocurre en los estadios más avanzados de la enfermedad
(III o IV). Dentro de los factores de riesgo descritos en la generación de este cáncer
se encuentran el consumo de tabaco, la inhalación y posterior acumulación de radón y
asbestos en el tejido pulmonar, la contaminación ambiental y la presencia de alteraciones
genéticas y de factores epigenéticos que regulan la expresión o represión de genes
involucrados con el desarrollo tumoral. Los mecanismos de regulación epigenética que
pueden intervenir en la progresión tumoral son: la metilación del ADN, la modificación
covalente de histonas y la presencia de ARN no codificantes. En las diferentes etapas
de progresión tumoral se ha descrito la participación de los mecanismos epigenéticos
como reguladores de procesos relacionados con proliferación, transición epiteliomesénquima,
metástasis, apoptosis, entre otros. Esta revisión de tema se enfoca en
describir el papel de la epigenética en la progresión tumoral pulmonar y plantea la
importancia de ampliar el conocimiento en esta disciplina con fines de diagnóstico y
tratamiento.

Keywords

epigenetic repression, DNA methylation, histone code, lung neoplasms, chromatin.represión epigenética, metilación de ADN, código de histonas, cáncer de pulmón, cromatina.

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Cómo citar
Rojas Moreno, A. P., Bruges, R. E., Cañas Arboleda, A., & Jaramillo García, L. F. (2017). Regulación epigenética en cáncer de pulmón: implicaciones para el clínico. Universitas Medica, 57(3), 332–347. https://doi.org/10.11144/Javeriana.umed57-3.recp
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