Resumen
Introducción: La tomografía computarizada (TC) es una herramienta diagnóstica indispensable; sin embargo, su uso creciente ha suscitado preocupación por el riesgo de cáncer asociado a la exposición a radiación ionizante. Objetivo: Evaluar sistemáticamente la relación entre exposición a TC y riesgo de cáncer, basándose en literatura científica de alta solidez metodológica. Métodos: Revisión sistemática independiente siguiendo la metodología PRISMA. Se consultaron bases de datos (PubMed, Scopus y Science Direct) utilizando descriptores controlados. La selección se llevó a cabo mediante el programa Rayyan, considerando artículos publicados entre enero de 2000 y abril de 2025. Resultados: Se seleccionaron 13 estudios. En conjunto, la evidencia apunta a una posible asociación entre la exposición a TC y un mayor riesgo de cáncer, especialmente en población pediátrica, con un patrón que sugiere dependencia de la dosis. Aunque algunos trabajos no alcanzaron significación estadística, la síntesis global de los datos respalda una tendencia que merece atención, reconociendo además la existencia de indicios de sesgo de publicación. Conclusión: La exposición a TC, particularmente en edades tempranas, se ha vinculado con un posible aumento en el riesgo de cáncer. En este contexto, resulta recomendable aplicar el principio ALARA y asegurar la adecuada justificación clínica de cada estudio, con el fin de reducir riesgos potenciales a largo plazo.
1. NCRP report no. 160: ionizing radiation exposure of the population of the United States., J Radiol Prot. 2009;29(3):465. https://doi.org/10.1088/0952-4746/29/3/B01
2. Brenner DJ, Hall EJ. Computed tomography — An increasing source of radiation exposure. N Engl J Med. 2007;357(22). https://doi.org/10.1056/NEJMra072149
3. Watson SJ, Jones AL, Oatway WB, Hughes JS. Ionising radiation exposure of the UK population: 2005 review [internet]. Health Protection Agency; 2005. Disponible en: https://www.gov.uk/government/publications/ionising-radiation-exposure-of-the-uk-population-2005-review
4. Mettler FA, Bhargavan M, Faulkner K, Gilley DB, Gray JE, Ibbott GS, et al. Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources - 1950-2007. Radiology. 2009;253(2). https://doi.org/10.1148/radiol.2532082010
5. Smith-Bindman R, Miglioretti DL, Johnson E, Lee C, Feigelson HS, Flynn M, et al. Use of diagnostic imaging studies and associated radiation exposure for patients enrolled in large integrated health care systems, 1996-2010. JAMA. 2012;307(22). https://doi.org/10.1001/jama.2012.5960
6. Lee J, Kirschner J, Pawa S, Wiener DE, Newman DH, Shah K. Computed tomography use in the adult emergency department of an academic urban hospital from 2001 to 2007. Ann Emerg Med. 2010;56(6). https://doi.org/10.1016/j.annemergmed.2010.05.027
7. Smith-Bindman R, Kwan ML, Marlow EC, Theis MK, Bolch W, Cheng SY, et al. Trends in use of medical imaging in US health care systems and in Ontario, Canada, 2000-2016. JAMA. 2019;322(9):843-56. https://doi.org/10.1001/jama.2019.11456
8. Zondervan RL, Hahn PF, Sadow CA, Liu B, Lee SI. Body CT scanning in young adults: examination indications, patient outcomes, and risk of radiation-induced cancer. Radiology. 2013;267(2). https://doi.org/10.1148/radiol.12121324
9. Lin EC. Radiation risk from medical imaging. Mayo Clinic Proc. 2010;85(12):1142-6. https://doi.org/10.4065/mcp.2010.0260
10. Bolus NE. Basic review of radiation biology and terminology. J Nucl Med Technol. 2017;45(4). https://doi.org/10.2967/jnmt.117.195230
11. Komemushi A, Takashima S, Nagai A, Usui M, Fukuda M, Nakatani M, et al. Practical radiation protection for interventional radiologist. Interv Radiol. 2022;7(2):54-7. https://doi.org/10.22575/interventionalradiology.2022-0004
12. LaDou J. Occupational medicine: the case for reform. Am J Prevent Med. 2005;28(4):396-402. https://doi.org/10.1016/j.amepre.2004.12.016
13. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103. Ann ICRP. 2007;37(2-4).
14. Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res. 2007;168(1). https://doi.org/10.1016/j.icrp.2007.10.003
15. Berrington de González A, Mahesh M, Kim KP, Bhargavan M, Lewis R, Mettler F, et al. Projected Cancer risks from computed tomographic scans performed in the United States in 2007. Arch Intern Med. 2009;169(22):2071-7. https://doi.org/10.1001/archinternmed.2009.440
16. Siegel JA, Greenspan BS, Maurer AH, Taylor AT, Phillips WT, Van Nostrand D, et al. The BEIR VII estimates of low-dose radiation health risks are based on faulty assumptions and data analyses: a call for reassessment. J Nucl Med. 2018;59(7). https://doi.org/10.2967/jnumed.117.206219
17. De Gonzalez AB, Pasqual E, Veiga L. Epidemiological studies of CT scans and cancer risk: The state of the science. Br J Radiol. 2021;29(7):1017-9. https://doi.org/10.2967/jnumed.117.206219
18. Brenner DJ, Hall EJ. Cancer risks from CT scans: now we have data, what next? Radiology. 2012;267(2). https://doi.org/10.1148/radiol.12121248
19. Miglioretti DL, Johnson E, Williams A, Greenlee RT, Weinmann S, Solberg LI, et al. The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr. 2013;167(8). https://doi.org/10.1001/jamapediatrics.2013.311
20. Brenner DJ, Elliston CD, Hall EJ, Berdon WE. Estimated risks of radiation-induced fatal cancer from pediatric CT. Am J Roentgenol. 2001;176(2). https://doi.org/10.2214/ajr.176.2.1760289
21. Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012;380(9840). https://doi.org/10.1016/S0140-6736(12)60815-0
22. Schultz CH, Fairley R, Murphy LSL, Doss M. The risk of cancer from CT scans and other sources of low-dose radiation: a critical appraisal of methodologic quality. Prehosp Disaster Med. 2020;35(1). https://doi.org/10.1017/S1049023X1900520X.
23. Hikino K, Yamamoto LG. The benefit of neck computed tomography compared with its harm (risk of cancer). J Trauma Acute Care Surg. 2015;78(1):126-31. https://doi.org/10.1097/TA.0000000000000465
24. Chen JX, Kachniarz B, Gilani S, Shin JJ. Risk of malignancy associated with head and neck CT in children: a systematic review. Otolaryngol Head Neck Surg (United States). 2014;151(4):554-66. https://doi.org/10.1177/0194599814542588
25. Pierce DA, Preston DL. Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat Res. 2000;154(2):178-86. https://doi.org/10.1667/0033-7587(2000)154[0178:rrcral]2.0.co;2
26. Hutton B, Catalá-López F, Moher D. The PRISMA statement extension for systematic reviews incorporating network meta-analysis: PRISMA-NMA. Med Clín (English Edition). 2016;147(6):262-6. https://doi.org/10.1016/j.medcli.2016.02.025
27. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group T. Ítems de referencia para publicar revisiones sistemáticas y metaanálisis: la declaración PRISMA. Rev Esp Nutr Hum Diet. 2014;18(3). https://doi.org/https://doi.org/10.14306/renhyd.18.3.114
28. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1). https://doi.org/10.1186/s13643-016-0384-4
29. Yu F, Liu C, Sharmin S. Performance, Usability, and user experience of rayyan for systematic reviews. Proc Assoc Inf Sci Technol. 2022;59(1):843-4. https://doi.org/10.1002/pra2.745
30. Shea BJ, Wells G, Thuku M, Hamel C, Moran J, Moher D, et al. AMSTAR 2 Tool. BMJ. 2017;18(1). https://doi.org/10.1136/bmj.j4008
31. Li L, Asemota I, Liu B, Gomez-Valencia J, Lin L, Arif AW, et al. AMSTAR 2 appraisal of systematic reviews and meta-analyses in the field of heart failure from high-impact journals. Syst Rev. 2022;11(1). https://doi.org/10.1186/s13643-022-02029-9
32. Wells G, Shea B, O’Connell D, Peterson J. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [internet]. Ottawa, ON: Ottawa Hospital Research Institute; 2000. Disponible en: https://ci.nii.ac.jp/naid/20000796643/
33. Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses [internet]. The Ottawa Hospital; 2012. Disponible en: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
34. Mathews JD, Forsythe A V., Brady Z, Butler MW, Goergen SK, Byrnes GB, et al. Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ. 2013 Jun 1;346(7910). https://doi.org/https://doi.org/10.1136/bmj.f2360
35. Hauptmann M, Byrnes G, Cardis E, Bernier MO, Blettner M, Dabin J, et al. Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study. Lancet Oncol. 2023 Jan 1;24(1):45-53. https://doi.org/10.1016/S1470-2045(22)00655-6
36. Han MA, Kim JH. Diagnostic X-ray exposure and thyroid cancer risk: systematic review and meta-analysis. Thyroid. 2018 Feb 1;28(2):220-8. https://doi.org/10.1089/thy.2017.0159.
37. Huang R, Liu X, He L, Zhou PK. Radiation exposure associated with computed tomography in childhood and the subsequent risk of cancer: a meta-analysis of cohort studies. Dose-Response. 2020 Apr 1;18(2). https://doi.org/10.1177/1559325820923828
38. Cao CF, Ma KL, Shan H, Liu TF, Zhao SQ, Wan Y, et al. CT scans and cancer risks: a systematic review and dose-response meta-analysis. BMC Cancer. 2022 Dec 1;22(1). https://doi.org/10.1186/s12885-022-10310-2
39. Abalo KD, Rage E, Leuraud K, Richardson DB, Le Pointe HD, Laurier D, et al. Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis. Pediatr Radiol. 2021 Jan 1;51(1):45-56 https://doi.org/10.1007/s00247-020-04803-0
40. Marcu LG, Chau M, Bezak E. How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults. Crit Rev Oncol Hematol. 2021;160:103292. https://doi.org/10.1016/j.critrevonc.2021.103292
41. Mack SLA. Eliminating the stigma: a systematic review of the health effects of low-dose radiation within the diagnostic imaging department and its implications for the future of medical radiation. J Med Imaging Radiat Sci. 2020;51(4):662-70. https://doi.org/10.1016/j.jmir.2020.07.052
42. Stålberg K, Haglund B, Axelsson O, Cnattingius S, Pfeifer S, Kieler H. Prenatal X-ray exposure and childhood brain tumours: a population-based case-control study on tumour subtypes. Br J Cancer. 2007 Dec 3;97(11):1583-7. https://doi.org/10.1038/sj.bjc.6604046
43. Journy N, Rehel JL, Ducou Le Pointe H, Lee C, Brisse H, Chateil JF, et al. Are the studies on cancer risk from CT scans biased by indication? Elements of answer from a large-scale cohort study in France. Br J Cancer. 2015 Jan 6;112(1):185-93. https://doi.org/10.1038/bjc.2014.526
44. Haberle S. The risk of cancer after computed tomography in pediatric patients: a systematic review. Chapel Hill: University of North Carolina at Chapel Hill; 2020. https://doi.org/10.17615/sxr7-ht21
45. Bernier MO, Journy N, Baysson H, Jacob S, Laurier D. Potential cancer risk associated with CT scans: review of epidemiological studies and ongoing studies. Progr Nucl Energy. 2015;84:116-9. https://doi.org/10.1016/j.pnucene.2014.07.011
46. Gibson DA, Moorin RE, Semmens J, Holman DJ. The disproportionate risk burden of CT scanning on females and younger adults in Australia: a retrospective cohort study. Aust N Z J Public Health. 2014;38(5). https://doi.org/10.1111/1753-6405.12278
47. Azman AS, Al-Shangeeti T, Al-Shehade S, Mohammed ME, Al-Sharif W, Al-Shamrani B, et al. Factors associated with CT-scan repetition among pediatrics and its relationship with cancer risk: a systematic review and meta-analysis protocol. Res Square. 2023. https://doi.org/10.21203/rs.3.rs-3148714/v1

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Derechos de autor 2025 Diana Isabel Espinoza Morales, Antonio Alvídrez Labrado, Araceli Zazueta Cárdenas, Juan Antonio Lugo Machado


