Neuromielitis óptica en el embarazo: reporte de un caso
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jul 6, 2014
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Resumen
La neuromielitis óptica (NMO) es una enfermedad inflamatoria autoinmune desmielinizante del sistema nervioso central, mediada por autoanticuerpos contra el receptor de acuaporina 4 (Ac IgQ4). Se presenta el caso de una mujer de 23 años de edad con 28 semanas de embarazo y antecedente de neuromielitis óptica, quien consultó por recaída de la enfermedad y pobre respuesta al manejo con corticosteroides, por lo que recibió 5 sesiones de plasmaféresis y tuvo una importante mejoría clínica.
Keywords
neuromielitis óptica, embarazo, plasmaféresis, inmunidad humoral, corticoesteroides, Neuromyelitis óptica, plasma exchange, humoral immunity, corticoesteroids, pregnancy,
References
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2. Kim W, Kim S-H, Nakashima I, Takai Y, Fujihara K, Leite MI, et al. Influence of pregnancy on neuromyelitis optica spectrum disorder. Neurology. 2012 Apr;78(16):1264-7.
3. Lucchinetti CF, Mandler R N, McGavern D, Bruck W, Gleich G, R ansohoff RM, et al. A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica. Brain [Internet]. 2002;125(Pt 7):1450-61. Disponibl en: http://linkinghub.elsevier.com/retrieve/pii/S0002939402017865.
4. Bourre B, Marignier R , Zéphir H, Papeix C, Brassat D, Castelnovo G, et al. Neuromyelitis optica and pregnancy. Neurology. 2012 Mar;78(12):875-9.
5. Wingerchuk DM, Lennon V a, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurology [Internet]. 2007 Sep;6(9):805-15. Disponibl en: http://www.ncbi.nlm.nih.gov/pubmed/23623397.
6. Collongues N, Marignier R , Zéphir H, Papeix C, Blanc F, R itleng C, et al. Neuromyelitis optica in France: a multicenter study of 125 patients. Neurology. 2010;74(9):736-42.
7. Pellkofer HL, Suessmair C, Schulze A, Hohlfeld R , Kuempfel T. Course of neuromyelitis optica during inadvertent pregnancy in a patient treated with rituximab. Mult Scler. 2009 Aug;15(8):1006-8.
8. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG. R evised diagnostic criteria for neuromyelitis optica. Neurology. 2006 May;66(10):1485-9.
9. Filippi M, R occa MA, Moiola L, Martinelli V, Ghezzi A, Capra R , et al. MRI and magnetization transfer imaging changes in the brain and cervical cord of patients with Devic’s neuromyelitis optica. Neurology. 1999 Nov;53(8):1705-10.
10. Morlat P, Hocke C, Vergnes C, Ellie E, Viallard J, Faure I, et al. Case report Devic’s neuromyelitis optica during pregnancy in a patient with systemic lupus erythematosus. Lupus. 1999;8(3):244-8.
11. Ratelade J, Verkman AS. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. Int J Biochem Cell Biol. 2012 Sep;44(9):1519-30.
12. Bukhari W, Barnett MH, Prain K, Broadley SA. Molecular pathogenesis of neuromyelitis optica. Int J Mol Sci. 2012 Jan;13(10):12970-93.
13. Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. Lancet Neurology. 2012 Jun;11(6):535-44.
14. Orthmann-Murphy JL, Abrams CK, Scherer SS. Gap junctions couple astrocytes and oligodendrocytes. Journal of molecular neuroscience : MN. 2008 May;35(1):101-16.
15. Pula JH, Macdonald CJ. Current options for the treatment of optic neuritis. Clin Ophthalmol [Internet]. 2012 Jan;6:1211-23. Disponibl en: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3422147&tool=pmcentrez&rendertype=abstract.
16. Sellner J, Boggild M, Clanet M, Hintzen R Q, Illes Z, Montalban X, et al. EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol. [Internet]. 2010 Aug [cited 2013 Mar 3];17(8):1019-32. Disponibl en: http://www.ncbi.nlm.nih.gov/pubmed/20528913.
17. McCarthy A, Dineen J, McKenna P, Keogan M, Sheehan J, Lynch T, et al. Anti-NMDA receptor encephalitis with associated catatonia during pregnancy. J Neurol. 2012 Dec;259(12):2632-5.
18. Heggermont WA, Verhelst C, De Wilde K, De Paepe M, Lacquet F, Vonck A. A case of HELLP syndrome: an immuno-“ logical” approach. Acta Clin Belg. 2012;67(5):375-7.
2. Kim W, Kim S-H, Nakashima I, Takai Y, Fujihara K, Leite MI, et al. Influence of pregnancy on neuromyelitis optica spectrum disorder. Neurology. 2012 Apr;78(16):1264-7.
3. Lucchinetti CF, Mandler R N, McGavern D, Bruck W, Gleich G, R ansohoff RM, et al. A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica. Brain [Internet]. 2002;125(Pt 7):1450-61. Disponibl en: http://linkinghub.elsevier.com/retrieve/pii/S0002939402017865.
4. Bourre B, Marignier R , Zéphir H, Papeix C, Brassat D, Castelnovo G, et al. Neuromyelitis optica and pregnancy. Neurology. 2012 Mar;78(12):875-9.
5. Wingerchuk DM, Lennon V a, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurology [Internet]. 2007 Sep;6(9):805-15. Disponibl en: http://www.ncbi.nlm.nih.gov/pubmed/23623397.
6. Collongues N, Marignier R , Zéphir H, Papeix C, Blanc F, R itleng C, et al. Neuromyelitis optica in France: a multicenter study of 125 patients. Neurology. 2010;74(9):736-42.
7. Pellkofer HL, Suessmair C, Schulze A, Hohlfeld R , Kuempfel T. Course of neuromyelitis optica during inadvertent pregnancy in a patient treated with rituximab. Mult Scler. 2009 Aug;15(8):1006-8.
8. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG. R evised diagnostic criteria for neuromyelitis optica. Neurology. 2006 May;66(10):1485-9.
9. Filippi M, R occa MA, Moiola L, Martinelli V, Ghezzi A, Capra R , et al. MRI and magnetization transfer imaging changes in the brain and cervical cord of patients with Devic’s neuromyelitis optica. Neurology. 1999 Nov;53(8):1705-10.
10. Morlat P, Hocke C, Vergnes C, Ellie E, Viallard J, Faure I, et al. Case report Devic’s neuromyelitis optica during pregnancy in a patient with systemic lupus erythematosus. Lupus. 1999;8(3):244-8.
11. Ratelade J, Verkman AS. Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies. Int J Biochem Cell Biol. 2012 Sep;44(9):1519-30.
12. Bukhari W, Barnett MH, Prain K, Broadley SA. Molecular pathogenesis of neuromyelitis optica. Int J Mol Sci. 2012 Jan;13(10):12970-93.
13. Papadopoulos MC, Verkman AS. Aquaporin 4 and neuromyelitis optica. Lancet Neurology. 2012 Jun;11(6):535-44.
14. Orthmann-Murphy JL, Abrams CK, Scherer SS. Gap junctions couple astrocytes and oligodendrocytes. Journal of molecular neuroscience : MN. 2008 May;35(1):101-16.
15. Pula JH, Macdonald CJ. Current options for the treatment of optic neuritis. Clin Ophthalmol [Internet]. 2012 Jan;6:1211-23. Disponibl en: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3422147&tool=pmcentrez&rendertype=abstract.
16. Sellner J, Boggild M, Clanet M, Hintzen R Q, Illes Z, Montalban X, et al. EFNS guidelines on diagnosis and management of neuromyelitis optica. Eur J Neurol. [Internet]. 2010 Aug [cited 2013 Mar 3];17(8):1019-32. Disponibl en: http://www.ncbi.nlm.nih.gov/pubmed/20528913.
17. McCarthy A, Dineen J, McKenna P, Keogan M, Sheehan J, Lynch T, et al. Anti-NMDA receptor encephalitis with associated catatonia during pregnancy. J Neurol. 2012 Dec;259(12):2632-5.
18. Heggermont WA, Verhelst C, De Wilde K, De Paepe M, Lacquet F, Vonck A. A case of HELLP syndrome: an immuno-“ logical” approach. Acta Clin Belg. 2012;67(5):375-7.
Cómo citar
Laurens Acevedo, M., Castañeda C., C., Ruiz de Sánchez, C., Rueda, M. C., & Zarco M., L. A. (2014). Neuromielitis óptica en el embarazo: reporte de un caso. Universitas Medica, 55(4), 456–465. https://doi.org/10.11144/Javeriana.umed55-4.noer
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Reportes de caso