This paper intends to develop some of the main aspects of Nietzsche's contribution to the enlargement of the concept of reason and to the rise of a philosophy of experience that is making it's way in contemporary thought. In Nietzsche's work, the kantian breed criticism turns in to genealogic hermeneutics that implies, on one hand, the demand of a radical criticism of several of the basic concepts of philosophy such as reason, truth, lie, life, on the other hand, the foundation of new parameters of interpretation such as the body, the topological nature of language and the creative instinct, considered as the most radical force within the human being. This paper focuses on Nietzsche's criticism of metaphysic truth from the perspective of the value of life and it's tragic sense. In the same order of ideas, this paper will state a few elements that are necessary to propose a truly rational experiential thought that may overcome epistemology and also go beyond the "conflict of the interpretations".