This article addresses the question regarding the ability of the Andean Multinational Enterprises for fostering intraregional inward investment within the pale of the Andean Community of Nations. The deficiencies in the philosophy behind the regime, inspired by the Regional Industrialisation Programme Model (RIPM), the insufficiency of the benefits, and the rigor of the requirements have conduced to an impairment of the regional scheme. This paper explores these problems studying the main characteristics of the transnational Andean corporations, assessing the role of the RIPM in the decay of the regime, and proposing a reform that moulds a new policy of business facilitation for regional investors.