The excessive use of drugs in the veterinary industry generates bioaccumulation in animal organs, tissues, muscles and fat. Depending on the concentration, these residues can reach man via the food chain. Food safety comprehends the use of these drugs and their residues such as sulfonamides, chloramphenicol and quinolones, which have been found in different slaughter animals. Some countries have limited regulations to control this issue. The implementation of standards set by the European Union is essential to monitor and control this problem at a national level. In this review, we use analytical techniques to identify the residues produced by
these drugs, focusing on recently developed technologies that are essential tools to control this problem. Liquid chromatography combined with mass spectrometry and its various interface systems is the most recommended
technology to detect residues in various food matrices.