The stress of parents of children with Down syndrome (DS) remains a handicap of interest to professionals throughout the process of intervention in early child care (0-6 years). This study aims to test whether there are differences in 78 parents of children with Down syndrome (3 to 11 months old), aged between 37 and 56 years (M = 46.5, SD = 1.94), using training based on the promotion of resilience. To achieve this goal an evaluation design with two mementos (before and after training) has been done, establishing a group of parents as experimental and another group for control. The results show positive effects on the stress experienced by parents of children with DS. In particular the level of parental stress resulting from reduced childcare derivative (SCC) and total stress (TS) is reduced after the implementation of the program. The importance of applying treatments to promote resilience in parents to amplify the positive effects of early care process in children with Down syndrome and their families is discussed.