In this article we explore frontierization practices, understood as the ways in which social groups mark an inside and an outside, in correlation with the differentiation we / others. We seek to identify how these practices operate in the dialectics State - ethnic minorities, which are core elements in the historic architecture of Latin American societies. Although as social constructs these boundaries emerge as sharp dividing lines, we address them as porous membranes selectively volatile, open to reconnections. In order to suggest some relevant and necessary analytical displacements that the current period fosters, we divided the text into four overlapping but distinguishable steps. We address first the dis / continuities in the border conceptualization in social thought. Then we enunciate how political boundaries influence the frontierization practices resulting from difference marking and recognition policies. After that, we examine what we understand as a pluralization of spatial, social and categorical boundaries. Finally, we address social and disciplinary challenges unleashed by the epistemic boundaries recognition