Theories of mechanically induced tissue differentiation and adaptation in the musculoskeletal system

Daniel R. Suárez

Abstract


It is well known that the mechanical environment affects biological tissues. The importance of theories and models that aim at explaining the role of the mechanical stimuli in process such as differentiation and adaptation of tissues is highlighted because if those theories can explain the tissue’s response to mechanical loading and to its environment, it becomes possible to predict the consequences of mechanical stimuli on growth, adaptation and ageing of tissues. This review aims to present an overview of the various theories and models on tissue differentiation and adaptation of tissues and their mathematical implementation.

Although current models are numerically well defined and are able to resemble the tissue differentiation and adaptation processes, they are limited by (1) the fact that some of their input parameters are likely to be site- and species-dependent, and (2) their verification is done by data that may make the model results redundant. However, some theories do have predictive power despite the limitations of generalization. It seems to be a matter of time until new experiments and models appear with predictive power and where rigorous verification can be performed.

Keywords


Computational biology, Mechanobiology; finite element; tissue growth; tissue differentiation; skeletal regeneration

Full Text:

PDF


DOI: http://dx.doi.org/10.11144/Javeriana.iyu20-1.tmit

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Add comment



Creative Commons
This work is registered under Creative Commons Attribution 4.0 International.
Created from http://revistas.javeriana.edu.co/.

 

The journal Ingeniería y Universidad is registered under a Creative Commons Attribution 4.0 International Public License. Thus, this work may be reproduced, distributed, and publicly shared in digital format, as long as the names of the authors and Pontificia Universidad Javeriana are acknowledged. Others are allowed to quote, adapt, transform, auto-archive, republish, and create based on this material, for any purpose (even commercial ones), provided the authorship is duly acknowledged, a link to the original work is provided, and it is specified if changes have been made. Pontificia Universidad Javeriana does not hold the rights of published works and the authors are solely responsible for the contents of their works; they keep the moral, intellectual, privacy, and publicity rights.

Approving the intervention of the work (review, copy-editing, translation, layout) and the following outreach, are granted through an use license and not through an assignment of rights. This means the journal and Pontificia Universidad Javeriana cannot be held responsible for any ethical malpractice by the authors. As a consequence of the protection granted by the use license, the journal is not required to publish recantations or modify information already published, unless the errata stems from the editorial management process. Publishing contents in this journal does not generate royalties for contributors.