Efectos de la inactivación sistémica de los receptores GR y MR sobre el daño rápido en la recuperación de la memoria espacial inducido por corticosterona
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may 18, 2017
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Resumen
Estudios previos de nuestro laboratorio han mostrado que diez minutos después de la administración sistémica de corticosterona se dificulta la recuperación de la memoria espacial en el laberinto de Barnes, sin embargo se desconocen los mecanismos que subyacen a este efecto. Dado que los glucocorticoides ejercen sus acciones a través de los receptores de tipo GR y MR, en el presente estudio se evaluó la participación de estos receptores en el efecto perjudicial rápido de la corticosterona sobre la memoria espacial. Para ello 37 ratas Wistar macho fueron entrenadas en la tarea y 24h después recibieron una inyección subcutánea de antagonista GR, antagonista MR o vehículo. 50min después los animales fueron inyectados con corticosterona o vehículo por vía intraperitoneal y 10min después se evaluó la recuperación de la memoria espacial. Los resultados mostraron que la corticosterona perjudicó rápidamente la recuperación de la memoria espacial a largo plazo, pues los animales inyectados con esta hormona presentaron mayores latencias de escape, mayor número de errores, mayor número de exploraciones y mayor distancia recorrida hasta alcanzar la meta; un efecto revertido solamente con la administración del antagonista MR. Este hallazgo concuerda con estudios in vitro donde se muestra que los efectos rápidos de la corticosterona sobre la trasmisión glutamatérgica en el hipocampo están mediados por los receptores MR.
Keywords
corticosterone, rapid deficit in recovery, spatial memory, Barnes maze, glucocorticoid receptorscorticosterona, déficit rápido, recuperación de la memoria espacial, laberinto de Barnes, receptores de glucocorticoides
References
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De Kloet, E., Oitzl, M., & Joëls M. (1999). Stress and cognition: Are corticosteroids good or bad guys? Trends in Neurosciences 22 (10), 422-426.
Di, S., Malcher-Lopes, R., Halmos, K., & Tasker, J. (2003). Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism. The journal of neuroscience 23(12), 4850–4857.
Di, S., Malcher-Lopes, R., Marcheselli, V., Bazan, N., & Tasker, J. (2005). Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and γ-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology 145(10), 4292–4301.
Di, S., Maxson, M., Franco, A., & Tasker, J. (2009). Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways. The journal of neuroscience 29(2), 393–401.
Galliot, E., Levaillant, M., Beard, E., Millot, J., & Pourié, G. (2010).Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus. Neurobiology of learning and memory 93, 196–202.
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Han, F., Ozawa, H., Matsuda, K., Nishi, M., & Kawata, M. (2004). Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus. Neuroscience research 51, 371-381.
Harrison, F. E., Hosseini, A. H., & McDonald, M. P. (2009). Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behavioural Brain Research 198(1), 247-251.
Harrison, F. E., Reiserer, R. S., Tomarken, A. J., & McDonald, M. P. (2006). Spatial and nonspatial escape strategies in the Barnes maze. Learning & Memory, 13(6):809-819. doi/10.1101/lm.334306.
Johnson, L., Farb, C., Morrison, J., MC Ewen, B., & Le Doux, J. (2005). Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136, 289–299.
Karst, H., et al. (2005).Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. PNAS 102 (52), 19204–19207.
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Nishi, M & Kawata, M. (2006). Brain corticosteroid receptor dynamics andtrafficking: Implications from live cell imaging. Neuroscientist 12 (2),119–133
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Prager, E., Brielmaier, J., Bergstrom, H., McGuire, J., & Johnson, L. (2010).Localization of Mineralocorticoid Receptors at Mammalian Synapses. PLoS ONE 5(12),1-10.
Pugh, C.R., Fleshner, M., & Rudy, J. W. (1997). Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats. Neurobiology of Learning and Memory, 67, 75–79.
Rashidy-Pour, A., Sadeghi, H., Taherain, A., Vafaei, A., & Fathollahi, Y. (2004). The effects of acute restraint stress and dexamethasone on retrieval of long-term memory in rats: an interaction with opiate system. Behavioural Brain Research 154, 193–198.
Roozendaal, B. (2000). Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology 25, 213 – 238.
Roozendaal, B. (2002). Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiology of Learning and Memory 78, 578 – 595.
Roozendaal B, de Quervain DJ, Schelling G, & McGaugh JL (2004). A systemically administered β-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats. Neurobiology of Learning and Memory, 81,150–154
Roozendaal, B., Griffith, Q., Buranday, J., de Quervain, D., & McGaugh, J. (2003). The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala. PNAS 100 (3), 1328–1333.
Roozendaal, B., & McGaugh, J. (1997).Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiology of learning and memory, 67, 176–179.
Schwabe, L., Joëls, M., Roozendaal, B., Wolf, O., & Oitzl, M. (2011). Stress effects on memory: An update and integration. Neuroscience and biobehavioral reviews 7, 740-749. doi:10.1016/j.neubiorev.2011.07.002.
Troncoso, J., Lamprea, M., Cuestas, D., & Múnera, A. (2010). El estrés agudo interfiere con la evocación y promueve la extinción de la memoria espacial en el laberinto de Barnes. Acta Biológica Colombian,15(1), 207- 222.
Zhou, M., Kindt, M., Joëls, M., & Krugers, H. J. (2011). Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in mice. PLoS ONE 6(10), 1-9.
Chao, H. M., Choo, P. H., & McEwen BS. (1989). Glucocorticoid and mineralocorticoid receptor mRNA expression in rat brain. Neuroendocrinology. 50(4), 365-71.
De Kloet, E., Joëls, M., & Holsboer, F. (2005). Stress and the brain: From adaptation to disease. Nature Reviews Neuroscience 6, 463 – 475.
De Kloet, E., Oitzl, M., & Joëls M. (1999). Stress and cognition: Are corticosteroids good or bad guys? Trends in Neurosciences 22 (10), 422-426.
Di, S., Malcher-Lopes, R., Halmos, K., & Tasker, J. (2003). Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism. The journal of neuroscience 23(12), 4850–4857.
Di, S., Malcher-Lopes, R., Marcheselli, V., Bazan, N., & Tasker, J. (2005). Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and γ-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology 145(10), 4292–4301.
Di, S., Maxson, M., Franco, A., & Tasker, J. (2009). Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways. The journal of neuroscience 29(2), 393–401.
Galliot, E., Levaillant, M., Beard, E., Millot, J., & Pourié, G. (2010).Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus. Neurobiology of learning and memory 93, 196–202.
Groeneweg, F., Karst, H., de Kloet, R., & Joëls, M. (2011a). Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signaling. Molecular and Cellular Endocrinology 2, 299-309. doi:10.1016/j.mce.2011.06.020.
Groeneweg, F., Karst, H., de Kloet, R., & Joëls, M. (2011b). Rapid non-genomic effects of corticosteroids and their role in the central stress response. Journal of Endocrinology 209, 153–167.
Haller, J; Mikics, E; & Makara, G. (2008).The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings. Frontiers in Neuroendocrinology, 29, 73–291.
Han, F., Ding, J., & Shi, J. (2014). Expression of amygdala mineralocorticoid receptor and glucocorticoid receptor in the single-prolonged stress rats. BMC Neuroscience 15 (77), 1-11
Han, F., Ozawa, H., Matsuda, K., Nishi, M., & Kawata, M. (2004). Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus. Neuroscience research 51, 371-381.
Harrison, F. E., Hosseini, A. H., & McDonald, M. P. (2009). Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behavioural Brain Research 198(1), 247-251.
Harrison, F. E., Reiserer, R. S., Tomarken, A. J., & McDonald, M. P. (2006). Spatial and nonspatial escape strategies in the Barnes maze. Learning & Memory, 13(6):809-819. doi/10.1101/lm.334306.
Johnson, L., Farb, C., Morrison, J., MC Ewen, B., & Le Doux, J. (2005). Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136, 289–299.
Karst, H., et al. (2005).Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. PNAS 102 (52), 19204–19207.
Khaksari, M., Rashidy-Pour, A., & Vafae, A. (2007). Central mineralocorticoid receptors are indispensable for corticosterone-induced impairment of memory retrieval in rats. Neuroscience 149,729–738.
Nishi, M & Kawata, M. (2006). Brain corticosteroid receptor dynamics andtrafficking: Implications from live cell imaging. Neuroscientist 12 (2),119–133
Nishi, M., Tanaka, M., Matsuda, K., Sunaguchi, M., & Kawata, M. (2004). Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer. The Journal of Neuroscience 24(21), 4918 – 4927.
Prado, M. (2009). Efectos de la inyección sistémica de corticosterona sobre la recuperación en una tarea de memoria espacial. Trabajo de grado. Universidad Nacional de Colombia sede Bogotá.
Prager, E., Brielmaier, J., Bergstrom, H., McGuire, J., & Johnson, L. (2010).Localization of Mineralocorticoid Receptors at Mammalian Synapses. PLoS ONE 5(12),1-10.
Pugh, C.R., Fleshner, M., & Rudy, J. W. (1997). Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats. Neurobiology of Learning and Memory, 67, 75–79.
Rashidy-Pour, A., Sadeghi, H., Taherain, A., Vafaei, A., & Fathollahi, Y. (2004). The effects of acute restraint stress and dexamethasone on retrieval of long-term memory in rats: an interaction with opiate system. Behavioural Brain Research 154, 193–198.
Roozendaal, B. (2000). Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology 25, 213 – 238.
Roozendaal, B. (2002). Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiology of Learning and Memory 78, 578 – 595.
Roozendaal B, de Quervain DJ, Schelling G, & McGaugh JL (2004). A systemically administered β-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats. Neurobiology of Learning and Memory, 81,150–154
Roozendaal, B., Griffith, Q., Buranday, J., de Quervain, D., & McGaugh, J. (2003). The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala. PNAS 100 (3), 1328–1333.
Roozendaal, B., & McGaugh, J. (1997).Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiology of learning and memory, 67, 176–179.
Schwabe, L., Joëls, M., Roozendaal, B., Wolf, O., & Oitzl, M. (2011). Stress effects on memory: An update and integration. Neuroscience and biobehavioral reviews 7, 740-749. doi:10.1016/j.neubiorev.2011.07.002.
Troncoso, J., Lamprea, M., Cuestas, D., & Múnera, A. (2010). El estrés agudo interfiere con la evocación y promueve la extinción de la memoria espacial en el laberinto de Barnes. Acta Biológica Colombian,15(1), 207- 222.
Zhou, M., Kindt, M., Joëls, M., & Krugers, H. J. (2011). Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in mice. PLoS ONE 6(10), 1-9.
Cómo citar
Urueña-Méndez, G. P., & Lamprea, M. (2017). Efectos de la inactivación sistémica de los receptores GR y MR sobre el daño rápido en la recuperación de la memoria espacial inducido por corticosterona. Universitas Psychologica, 15(5). https://doi.org/10.11144/Javeriana.upsy15-5.eisr
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