Developing a Social Cognition Task for fMRI in Patients with Mild Traumatic Brain Injury
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may 18, 2017
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Pablo Alexander Reyes Gavilan
http://orcid.org/0000-0001-6705-7157
Diana Lucia Matallana
Giselle Santiago
Carlos Filizzola
Anibal Morillo
Sofia Velasco
Sonia Bermúdez
http://orcid.org/0000-0001-6705-7157
Diana Lucia Matallana
Giselle Santiago
Carlos Filizzola
Anibal Morillo
Sofia Velasco
Sonia Bermúdez
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Resumen
Social cognition impairments are frequently found in patients with mild traumatic brain injury (TBI) when structural lesions may not reveal the severity of the injury. Though instruments used to assess social behavior are thought to be sensitive, the absence of structural damage in TBI patients may lead to underscore such problems. The aim of this study was to develop a complementary diagnostic tool such as a paradigm for functional Magnetic resonance Imaging (fMRI) involving a simple task that could tell how patients understand certain complex social behavior by identifying different movements with or without social intentions where language and complex cognitive process were not required. Eleven patients with mild TBI and social cognition difficulties and twelve control subjects were matched by demographic variables. A paradigm of social fMRI was developed by using dots in movement representing human motion, human motion with social intention such as dancing or sharing, and dots moving without meaning. Patients had less activation in parietotemporal junction and bilateral middle frontal gyrus in the social perception task movement compared with control group subjects. The fMRI paradigm developed can be an additional diagnostic tool for identifying social cognition impairments in mild TBI patients. Regardless the absence of structural injury, changes in activation areas suggest a prospective use of this tool since clinical, cognitive and functional outcomes support such finding.
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References
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Belanger, H. G., Vanderploeg, R. D., Curtiss, G., & Warden, D. L. (2007). Recent neuroimaging techniques in mild traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 5–20. http://doi.org/10.1176/appi.neuropsych.19.1.5
Brett, M., Anton, J.-L., Valabregue, R., & Poline, J.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. Neuroimage, 16(2), S497.
Carp, J. (2012). The secret lives of experiments: Methods reporting in the fMRI literature. NeuroImage, 63(1), 289–300. http://doi.org/10.1016/j.neuroimage.2012.07.004
de Vignemont, F., & Singer, T. (2006). The empathic brain: how, when and why? Trends in Cognitive Sciences, 10(10), 435–441. http://doi.org/10.1016/j.tics.2006.08.008
Diedrichsen, J., & Shadmehr, R. (2005). Detecting and Adjusting for Artifacts in fMRI Time Series Data. NeuroImage, 27(3), 624–634. http://doi.org/10.1016/j.neuroimage.2005.04.039
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Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-Related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3), 346–355. http://doi.org/10.1002/mrm.1910350312
Hassan, S. T. S., Khaw, W. F., Rosna, A. R., & Husna, J. (2011). Traumatic brain injury: caregivers’ problems and needs. JNMA; Journal of the Nepal Medical Association, 51(181), 53–55.
Ho, S. S., Gonzalez, R. D., Abelson, J. L., & Liberzon, I. (2012). Neurocircuits underlying cognition-emotion interaction in a social decision making context. NeuroImage, 63(2), 843–57. http://doi.org/10.1016/j.neuroimage.2012.07.017
Huisman, T. A. G. M., Schwamm, L. H., Schaefer, P. W., Koroshetz, W. J., Shetty-Alva, N., Ozsunar, Y., … Sorensen, A. G. (2004). Diffusion Tensor Imaging as Potential Biomarker of White Matter Injury in Diffuse Axonal Injury. American Journal of Neuroradiology, 25(3), 370–376.
Hulkower, M. B., Poliak, D. B., Rosenbaum, S. B., Zimmerman, M. E., & Lipton, M. L. (2013). A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later. American Journal of Neuroradiology. http://doi.org/10.3174/ajnr.A3395
Ibanez, A., Kuljis, R. O., Matallana, D., & Manes, F. (2014). Bridging psychiatry and neurology through social neuroscience. World Psychiatry, 13(2), 148–149. http://doi.org/10.1002/wps.20125
Ichikawa, N., Siegle, G. J., Jones, N. P., Kamishima, K., Thompson, W. K., Gross, J. J., & Ohira, H. (2011). Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex. Cognitive, Affective & Behavioral Neuroscience, 11(3), 354–71. http://doi.org/10.3758/s13415-011-0028-z
Jumisko, E., Lexell, J., & Söderberg, S. (2007). Living with moderate or severe traumatic brain injury: the meaning of family members’ experiences. Journal of Family Nursing, 13(3), 353–369. http://doi.org/10.1177/1074840707303842
Kreutzer, J. S., Gervasio, A. H., & Camplair, P. S. (1994). Patient correlates of caregivers’ distress and family functioning after traumatic brain injury. Brain Injury: [BI], 8(3), 211–230.
Leslie, K. R., Johnson-Frey, S. H., & Grafton, S. T. (2004). Functional imaging of face and hand imitation: towards a motor theory of empathy. NeuroImage, 21(2), 601–607. http://doi.org/10.1016/j.neuroimage.2003.09.038
LoBue, C., Denney, D., Hynan, L. S., Rossetti, H. C., Lacritz, L. H., Hart, J., … Cullum, C. M. (2016). Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. Journal of Alzheimer’s Disease, 51(3), 727–736. http://doi.org/10.3233/JAD-150895
Martín-Rodríguez, J. F., & León-Carrión, J. (2010). Theory of mind deficits in patients with acquired brain injury: A quantitative review. Neuropsychologia, 48(5), 1181–1191. http://doi.org/10.1016/j.neuropsychologia.2010.02.009
McDonald, S., Flanagan, S., Rollins, J., & Kinch, J. (2003). TASIT: A new clinical tool for assessing social perception after traumatic brain injury. The Journal of Head Trauma Rehabilitation, 18(3), 219–238.
Metting, Z., Cerliani, L., Rödiger, L. A., & van der Naalt, J. (2013). Pathophysiological Concepts in Mild Traumatic Brain Injury: Diffusion Tensor Imaging Related to Acute Perfusion CT Imaging. PLoS ONE, 8(5), e64461. http://doi.org/10.1371/journal.pone.0064461
Pfeifer, J. H., Iacoboni, M., Mazziotta, J. C., & Dapretto, M. (2008). Mirroring others’ emotions relates to empathy and interpersonal competence in children. NeuroImage, 39(4), 2076–2085. http://doi.org/10.1016/j.neuroimage.2007.10.032
Raposo, A., Vicens, L., Clithero, J. A., Dobbins, I. G., & Huettel, S. A. (2011). Contributions of frontopolar cortex to judgments about self, others and relations. Social Cognitive and Affective Neuroscience, 6(3), 260–9. http://doi.org/10.1093/scan/nsq033
Rizzolatti, G., Fogassi, L., & Gallese, V. (2002). Motor and cognitive functions of the ventral premotor cortex. Current Opinion in Neurobiology, 12(2), 149–154. http://doi.org/10.1016/S0959-4388(02)00308-2
Schroeter, M. L., Ettrich, B., Menz, M., & Zysset, S. (2010). Traumatic brain injury affects the frontomedian cortex—An event-related fMRI study on evaluative judgments. Neuropsychologia, 48(1), 185–193. http://doi.org/10.1016/j.neuropsychologia.2009.09.004
Stulemeijer, M., Vos, P. E., Bleijenberg, G., & van der Werf, S. P. (2007). Cognitive complaints after mild traumatic brain injury: Things are not always what they seem. Journal of Psychosomatic Research, 63(6), 637–645. http://doi.org/10.1016/j.jpsychores.2007.06.023
Turkstra, L. S. (2008). Conversation-based assessment of social cognition in adults with traumatic brain injury. Brain Injury : [BI], 22(5), 397–409. http://doi.org/10.1080/02699050802027059
Turkstra, L. S., Williams, W. H., Tonks, J., & Frampton, I. (2008). Measuring social cognition in adolescents: implications for students with TBI returning to school. NeuroRehabilitation, 23(6), 501–9.
Van Essen, D. C. (2005). A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. NeuroImage, 28(3), 635–662. http://doi.org/10.1016/j.neuroimage.2005.06.058
Van Essen, D. C., Drury, H. a., Dickson, J., Harwell, J., Hanlon, D., & Anderson, C. H. (2001). An Integrated Software Suite for Surface-based Analyses of Cerebral Cortex. Journal of the American Medical Informatics Association, 8(5), 443–459. http://doi.org/10.1136/jamia.2001.0080443
Wheaton, K. J., Thompson, J. C., Syngeniotis, A., Abbott, D. F., & Puce, A. (2004). Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. NeuroImage, 22(1), 277–288. http://doi.org/10.1016/j.neuroimage.2003.12.043
Arciniegas, D. B., Topkoff, J., & Silver, J. M. (2000). Neuropsychiatric aspects of traumatic brain injury. Current Treatment Options in Neurology, 2(2), 169–186.
Ashburner, J., Barnes, G., Chen, C., Daunizeau, J., Flandin, G., Friston, K., … Litvak, V. (2008). SPM8 manual. Functional Imaging Laboratory, Institute of Neurology.
Avants, B., Duda, J. T., Kim, J., Zhang, H., Pluta, J., Gee, J. C., & Whyte, J. (2008). Multivariate {Analysis} of {Structural} and {Diffusion} {Imaging} in {Traumatic} {Brain} {Injury}. Academic Radiology, 15(11), 1360–1375. article. http://doi.org/10.1016/j.acra.2008.07.007
Barker-Collo, S., Jones, K., Theadom, A., Starkey, N., Dowell, A., McPherson, K., … Feigin, V. (2015). Neuropsychological outcome and its correlates in the first year after adult mild traumatic brain injury: A population-based New Zealand study. Brain Injury, 29(13–14), 1604–1616. http://doi.org/10.3109/02699052.2015.1075143
Belanger, H. G., Vanderploeg, R. D., Curtiss, G., & Warden, D. L. (2007). Recent neuroimaging techniques in mild traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 5–20. http://doi.org/10.1176/appi.neuropsych.19.1.5
Brett, M., Anton, J.-L., Valabregue, R., & Poline, J.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. Neuroimage, 16(2), S497.
Carp, J. (2012). The secret lives of experiments: Methods reporting in the fMRI literature. NeuroImage, 63(1), 289–300. http://doi.org/10.1016/j.neuroimage.2012.07.004
de Vignemont, F., & Singer, T. (2006). The empathic brain: how, when and why? Trends in Cognitive Sciences, 10(10), 435–441. http://doi.org/10.1016/j.tics.2006.08.008
Diedrichsen, J., & Shadmehr, R. (2005). Detecting and Adjusting for Artifacts in fMRI Time Series Data. NeuroImage, 27(3), 624–634. http://doi.org/10.1016/j.neuroimage.2005.04.039
Ebisch, S. J. H., Ferri, F., Salone, A., Perrucci, M. G., D’Amico, L., Ferro, F. M., … Gallese, V. (2011). Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch. Journal of Cognitive Neuroscience, 23(7), 1808–1822. http://doi.org/10.1162/jocn.2010.21551
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-Related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3), 346–355. http://doi.org/10.1002/mrm.1910350312
Hassan, S. T. S., Khaw, W. F., Rosna, A. R., & Husna, J. (2011). Traumatic brain injury: caregivers’ problems and needs. JNMA; Journal of the Nepal Medical Association, 51(181), 53–55.
Ho, S. S., Gonzalez, R. D., Abelson, J. L., & Liberzon, I. (2012). Neurocircuits underlying cognition-emotion interaction in a social decision making context. NeuroImage, 63(2), 843–57. http://doi.org/10.1016/j.neuroimage.2012.07.017
Huisman, T. A. G. M., Schwamm, L. H., Schaefer, P. W., Koroshetz, W. J., Shetty-Alva, N., Ozsunar, Y., … Sorensen, A. G. (2004). Diffusion Tensor Imaging as Potential Biomarker of White Matter Injury in Diffuse Axonal Injury. American Journal of Neuroradiology, 25(3), 370–376.
Hulkower, M. B., Poliak, D. B., Rosenbaum, S. B., Zimmerman, M. E., & Lipton, M. L. (2013). A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later. American Journal of Neuroradiology. http://doi.org/10.3174/ajnr.A3395
Ibanez, A., Kuljis, R. O., Matallana, D., & Manes, F. (2014). Bridging psychiatry and neurology through social neuroscience. World Psychiatry, 13(2), 148–149. http://doi.org/10.1002/wps.20125
Ichikawa, N., Siegle, G. J., Jones, N. P., Kamishima, K., Thompson, W. K., Gross, J. J., & Ohira, H. (2011). Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex. Cognitive, Affective & Behavioral Neuroscience, 11(3), 354–71. http://doi.org/10.3758/s13415-011-0028-z
Jumisko, E., Lexell, J., & Söderberg, S. (2007). Living with moderate or severe traumatic brain injury: the meaning of family members’ experiences. Journal of Family Nursing, 13(3), 353–369. http://doi.org/10.1177/1074840707303842
Kreutzer, J. S., Gervasio, A. H., & Camplair, P. S. (1994). Patient correlates of caregivers’ distress and family functioning after traumatic brain injury. Brain Injury: [BI], 8(3), 211–230.
Leslie, K. R., Johnson-Frey, S. H., & Grafton, S. T. (2004). Functional imaging of face and hand imitation: towards a motor theory of empathy. NeuroImage, 21(2), 601–607. http://doi.org/10.1016/j.neuroimage.2003.09.038
LoBue, C., Denney, D., Hynan, L. S., Rossetti, H. C., Lacritz, L. H., Hart, J., … Cullum, C. M. (2016). Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. Journal of Alzheimer’s Disease, 51(3), 727–736. http://doi.org/10.3233/JAD-150895
Martín-Rodríguez, J. F., & León-Carrión, J. (2010). Theory of mind deficits in patients with acquired brain injury: A quantitative review. Neuropsychologia, 48(5), 1181–1191. http://doi.org/10.1016/j.neuropsychologia.2010.02.009
McDonald, S., Flanagan, S., Rollins, J., & Kinch, J. (2003). TASIT: A new clinical tool for assessing social perception after traumatic brain injury. The Journal of Head Trauma Rehabilitation, 18(3), 219–238.
Metting, Z., Cerliani, L., Rödiger, L. A., & van der Naalt, J. (2013). Pathophysiological Concepts in Mild Traumatic Brain Injury: Diffusion Tensor Imaging Related to Acute Perfusion CT Imaging. PLoS ONE, 8(5), e64461. http://doi.org/10.1371/journal.pone.0064461
Pfeifer, J. H., Iacoboni, M., Mazziotta, J. C., & Dapretto, M. (2008). Mirroring others’ emotions relates to empathy and interpersonal competence in children. NeuroImage, 39(4), 2076–2085. http://doi.org/10.1016/j.neuroimage.2007.10.032
Raposo, A., Vicens, L., Clithero, J. A., Dobbins, I. G., & Huettel, S. A. (2011). Contributions of frontopolar cortex to judgments about self, others and relations. Social Cognitive and Affective Neuroscience, 6(3), 260–9. http://doi.org/10.1093/scan/nsq033
Rizzolatti, G., Fogassi, L., & Gallese, V. (2002). Motor and cognitive functions of the ventral premotor cortex. Current Opinion in Neurobiology, 12(2), 149–154. http://doi.org/10.1016/S0959-4388(02)00308-2
Schroeter, M. L., Ettrich, B., Menz, M., & Zysset, S. (2010). Traumatic brain injury affects the frontomedian cortex—An event-related fMRI study on evaluative judgments. Neuropsychologia, 48(1), 185–193. http://doi.org/10.1016/j.neuropsychologia.2009.09.004
Stulemeijer, M., Vos, P. E., Bleijenberg, G., & van der Werf, S. P. (2007). Cognitive complaints after mild traumatic brain injury: Things are not always what they seem. Journal of Psychosomatic Research, 63(6), 637–645. http://doi.org/10.1016/j.jpsychores.2007.06.023
Turkstra, L. S. (2008). Conversation-based assessment of social cognition in adults with traumatic brain injury. Brain Injury : [BI], 22(5), 397–409. http://doi.org/10.1080/02699050802027059
Turkstra, L. S., Williams, W. H., Tonks, J., & Frampton, I. (2008). Measuring social cognition in adolescents: implications for students with TBI returning to school. NeuroRehabilitation, 23(6), 501–9.
Van Essen, D. C. (2005). A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. NeuroImage, 28(3), 635–662. http://doi.org/10.1016/j.neuroimage.2005.06.058
Van Essen, D. C., Drury, H. a., Dickson, J., Harwell, J., Hanlon, D., & Anderson, C. H. (2001). An Integrated Software Suite for Surface-based Analyses of Cerebral Cortex. Journal of the American Medical Informatics Association, 8(5), 443–459. http://doi.org/10.1136/jamia.2001.0080443
Wheaton, K. J., Thompson, J. C., Syngeniotis, A., Abbott, D. F., & Puce, A. (2004). Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. NeuroImage, 22(1), 277–288. http://doi.org/10.1016/j.neuroimage.2003.12.043
Cómo citar
Reyes Gavilan, P. A., Matallana, D. L., Santiago, G., Filizzola, C., Morillo, A., Velasco, S., & Bermúdez, S. (2017). Developing a Social Cognition Task for fMRI in Patients with Mild Traumatic Brain Injury. Universitas Psychologica, 15(5). https://doi.org/10.11144/Javeriana.upsy15-5.dsct
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