Keywords
resonancia magnética funcional
trauma craneoencefálico
How to Cite
Abstract
Los cambios en la cognición social son encontrados frecuentemente en pacientes con trauma craneoencefálico leve (TCE) aunque no exista evidencia de lesiones estructurales. Aunque los instrumentos utilizados para evaluar la cognición social son sensibles al cambio, la ausencia de daño estructural en los pacientes con TCE, puede llevar pasar por inadvertidos estos problemas. El objetivo de este estudio fue desarrollar una herramienta diagnóstica complementaria como un paradigma para resonancia magnética funcional (RMf), la cual involucra una tarea simple que pudiera explicar cómo los pacientes entienden ciertos comportamientos sociales complejos por medio de movimientos con o sin intención social sin intermediación del lenguaje. Participaron once pacientes con TCE leve y con reporte de alteraciones en cognición social, estos fueron emparejados con doce sujetos control por variables demográficas. Un paradigma de RMf fue desarrollado por medio de la animación puntos blancos sobre una pantalla negra que representan el movimiento humano, el movimiento humano con la intención social como el baile o el compartir, y puntos que se mueven sin significado. Los pacientes tuvieron menos activación en la unión parietotemporal y giro frontal medio bilateral frente al movimiento social en comparación con los sujetos del grupo de control. El paradigma de fMRI desarrollado puede ser una herramienta de diagnóstico adicional para identificar las alteraciones cognitivas sociales en pacientes con TCE leve. Independientemente de la ausencia de lesión estructural, los cambios en las áreas de activación sugieren la posibilidad de usar esta herramienta como pronóstico dado que los resultados clínicos, cognitivos y funcionales soportan este hallazgo.
Amyot, F., Arciniegas, D. B., Brazaitis, M. P., Curley, K. C., Diaz-Arrastia, R., Gandjbakhche, A., … Stocker, D. (2015). A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury. Journal of Neurotrauma, 32(22), 1693–721. http://doi.org/10.1089/neu.2013.3306
Arciniegas, D. B., Topkoff, J., & Silver, J. M. (2000). Neuropsychiatric aspects of traumatic brain injury. Current Treatment Options in Neurology, 2(2), 169–186.
Ashburner, J., Barnes, G., Chen, C., Daunizeau, J., Flandin, G., Friston, K., … Litvak, V. (2008). SPM8 manual. Functional Imaging Laboratory, Institute of Neurology.
Avants, B., Duda, J. T., Kim, J., Zhang, H., Pluta, J., Gee, J. C., & Whyte, J. (2008). Multivariate {Analysis} of {Structural} and {Diffusion} {Imaging} in {Traumatic} {Brain} {Injury}. Academic Radiology, 15(11), 1360–1375. article. http://doi.org/10.1016/j.acra.2008.07.007
Barker-Collo, S., Jones, K., Theadom, A., Starkey, N., Dowell, A., McPherson, K., … Feigin, V. (2015). Neuropsychological outcome and its correlates in the first year after adult mild traumatic brain injury: A population-based New Zealand study. Brain Injury, 29(13–14), 1604–1616. http://doi.org/10.3109/02699052.2015.1075143
Belanger, H. G., Vanderploeg, R. D., Curtiss, G., & Warden, D. L. (2007). Recent neuroimaging techniques in mild traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 5–20. http://doi.org/10.1176/appi.neuropsych.19.1.5
Brett, M., Anton, J.-L., Valabregue, R., & Poline, J.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. Neuroimage, 16(2), S497.
Carp, J. (2012). The secret lives of experiments: Methods reporting in the fMRI literature. NeuroImage, 63(1), 289–300. http://doi.org/10.1016/j.neuroimage.2012.07.004
de Vignemont, F., & Singer, T. (2006). The empathic brain: how, when and why? Trends in Cognitive Sciences, 10(10), 435–441. http://doi.org/10.1016/j.tics.2006.08.008
Diedrichsen, J., & Shadmehr, R. (2005). Detecting and Adjusting for Artifacts in fMRI Time Series Data. NeuroImage, 27(3), 624–634. http://doi.org/10.1016/j.neuroimage.2005.04.039
Ebisch, S. J. H., Ferri, F., Salone, A., Perrucci, M. G., D’Amico, L., Ferro, F. M., … Gallese, V. (2011). Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch. Journal of Cognitive Neuroscience, 23(7), 1808–1822. http://doi.org/10.1162/jocn.2010.21551
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-Related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3), 346–355. http://doi.org/10.1002/mrm.1910350312
Hassan, S. T. S., Khaw, W. F., Rosna, A. R., & Husna, J. (2011). Traumatic brain injury: caregivers’ problems and needs. JNMA; Journal of the Nepal Medical Association, 51(181), 53–55.
Ho, S. S., Gonzalez, R. D., Abelson, J. L., & Liberzon, I. (2012). Neurocircuits underlying cognition-emotion interaction in a social decision making context. NeuroImage, 63(2), 843–57. http://doi.org/10.1016/j.neuroimage.2012.07.017
Huisman, T. A. G. M., Schwamm, L. H., Schaefer, P. W., Koroshetz, W. J., Shetty-Alva, N., Ozsunar, Y., … Sorensen, A. G. (2004). Diffusion Tensor Imaging as Potential Biomarker of White Matter Injury in Diffuse Axonal Injury. American Journal of Neuroradiology, 25(3), 370–376.
Hulkower, M. B., Poliak, D. B., Rosenbaum, S. B., Zimmerman, M. E., & Lipton, M. L. (2013). A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later. American Journal of Neuroradiology. http://doi.org/10.3174/ajnr.A3395
Ibanez, A., Kuljis, R. O., Matallana, D., & Manes, F. (2014). Bridging psychiatry and neurology through social neuroscience. World Psychiatry, 13(2), 148–149. http://doi.org/10.1002/wps.20125
Ichikawa, N., Siegle, G. J., Jones, N. P., Kamishima, K., Thompson, W. K., Gross, J. J., & Ohira, H. (2011). Feeling bad about screwing up: emotion regulation and action monitoring in the anterior cingulate cortex. Cognitive, Affective & Behavioral Neuroscience, 11(3), 354–71. http://doi.org/10.3758/s13415-011-0028-z
Jumisko, E., Lexell, J., & Söderberg, S. (2007). Living with moderate or severe traumatic brain injury: the meaning of family members’ experiences. Journal of Family Nursing, 13(3), 353–369. http://doi.org/10.1177/1074840707303842
Kreutzer, J. S., Gervasio, A. H., & Camplair, P. S. (1994). Patient correlates of caregivers’ distress and family functioning after traumatic brain injury. Brain Injury: [BI], 8(3), 211–230.
Leslie, K. R., Johnson-Frey, S. H., & Grafton, S. T. (2004). Functional imaging of face and hand imitation: towards a motor theory of empathy. NeuroImage, 21(2), 601–607. http://doi.org/10.1016/j.neuroimage.2003.09.038
LoBue, C., Denney, D., Hynan, L. S., Rossetti, H. C., Lacritz, L. H., Hart, J., … Cullum, C. M. (2016). Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. Journal of Alzheimer’s Disease, 51(3), 727–736. http://doi.org/10.3233/JAD-150895
Martín-Rodríguez, J. F., & León-Carrión, J. (2010). Theory of mind deficits in patients with acquired brain injury: A quantitative review. Neuropsychologia, 48(5), 1181–1191. http://doi.org/10.1016/j.neuropsychologia.2010.02.009
McDonald, S., Flanagan, S., Rollins, J., & Kinch, J. (2003). TASIT: A new clinical tool for assessing social perception after traumatic brain injury. The Journal of Head Trauma Rehabilitation, 18(3), 219–238.
Metting, Z., Cerliani, L., Rödiger, L. A., & van der Naalt, J. (2013). Pathophysiological Concepts in Mild Traumatic Brain Injury: Diffusion Tensor Imaging Related to Acute Perfusion CT Imaging. PLoS ONE, 8(5), e64461. http://doi.org/10.1371/journal.pone.0064461
Pfeifer, J. H., Iacoboni, M., Mazziotta, J. C., & Dapretto, M. (2008). Mirroring others’ emotions relates to empathy and interpersonal competence in children. NeuroImage, 39(4), 2076–2085. http://doi.org/10.1016/j.neuroimage.2007.10.032
Raposo, A., Vicens, L., Clithero, J. A., Dobbins, I. G., & Huettel, S. A. (2011). Contributions of frontopolar cortex to judgments about self, others and relations. Social Cognitive and Affective Neuroscience, 6(3), 260–9. http://doi.org/10.1093/scan/nsq033
Rizzolatti, G., Fogassi, L., & Gallese, V. (2002). Motor and cognitive functions of the ventral premotor cortex. Current Opinion in Neurobiology, 12(2), 149–154. http://doi.org/10.1016/S0959-4388(02)00308-2
Schroeter, M. L., Ettrich, B., Menz, M., & Zysset, S. (2010). Traumatic brain injury affects the frontomedian cortex—An event-related fMRI study on evaluative judgments. Neuropsychologia, 48(1), 185–193. http://doi.org/10.1016/j.neuropsychologia.2009.09.004
Stulemeijer, M., Vos, P. E., Bleijenberg, G., & van der Werf, S. P. (2007). Cognitive complaints after mild traumatic brain injury: Things are not always what they seem. Journal of Psychosomatic Research, 63(6), 637–645. http://doi.org/10.1016/j.jpsychores.2007.06.023
Turkstra, L. S. (2008). Conversation-based assessment of social cognition in adults with traumatic brain injury. Brain Injury : [BI], 22(5), 397–409. http://doi.org/10.1080/02699050802027059
Turkstra, L. S., Williams, W. H., Tonks, J., & Frampton, I. (2008). Measuring social cognition in adolescents: implications for students with TBI returning to school. NeuroRehabilitation, 23(6), 501–9.
Van Essen, D. C. (2005). A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. NeuroImage, 28(3), 635–662. http://doi.org/10.1016/j.neuroimage.2005.06.058
Van Essen, D. C., Drury, H. a., Dickson, J., Harwell, J., Hanlon, D., & Anderson, C. H. (2001). An Integrated Software Suite for Surface-based Analyses of Cerebral Cortex. Journal of the American Medical Informatics Association, 8(5), 443–459. http://doi.org/10.1136/jamia.2001.0080443
Wheaton, K. J., Thompson, J. C., Syngeniotis, A., Abbott, D. F., & Puce, A. (2004). Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. NeuroImage, 22(1), 277–288. http://doi.org/10.1016/j.neuroimage.2003.12.043
This journal is registered under a Creative Commons Attribution 4.0 International Public License. Thus, this work may be reproduced, distributed, and publicly shared in digital format, as long as the names of the authors and Pontificia Universidad Javeriana are acknowledged. Others are allowed to quote, adapt, transform, auto-archive, republish, and create based on this material, for any purpose (even commercial ones), provided the authorship is duly acknowledged, a link to the original work is provided, and it is specified if changes have been made. Pontificia Universidad Javeriana does not hold the rights of published works and the authors are solely responsible for the contents of their works; they keep the moral, intellectual, privacy, and publicity rights. Approving the intervention of the work (review, copy-editing, translation, layout) and the following outreach, are granted through an use license and not through an assignment of rights. This means the journal and Pontificia Universidad Javeriana cannot be held responsible for any ethical malpractice by the authors. As a consequence of the protection granted by the use license, the journal is not required to publish recantations or modify information already published, unless the errata stems from the editorial management process. Publishing contents in this journal does not generate royalties for contributors.