Keywords
interval timing
DLPFC
tDCS
How to Cite
Abstract
There is evidence supporting the importance of the dorsolateral prefrontal cortex (DLPFC) in the perception of time. The tDCS (transcranial direct current stimulation) modulates cortical excitability and can be applied to influence the performance of different brain functions, such as timing. Our objective was to evaluate the effect of stimulation of right and left DLPFC on a task of production of time. 26 patients underwent transcranial stimulation of 2mA over the DLPFC for 20 min (anodic, cathodic or sham). Then they participated in a reproduction task of 4 and 8 seconds. Through ANOVA for repeated measures for stimulating factors (anode, cathode, sham), intervals (4s and / or 8s) and location (left and right), we observed that the anodic stimulation of the right DLPFC resulted in greater underestimation in 4-seconds interval, while the use of cathodic current on the left DLPFC caused an overestimation of 4-seconds interval. Our results confirm the importance of the right DLPFC in the perception of time. Furthermore, the observed asymmetric effect is interesting, confirming that the left DLPFC is associated with the executive, important roles in perception of time.
Block, R. A., Hancock, P. A., & Zakay, D. (2010). How cognitive load affects duration judgments: A meta-analytic review. Acta Psychologica, 134, 330-343.
Coull, J. T., Vidal, F., Nazarian, B., Macar, F. (2004) Functional anatomy of the attentional modulation of time estimation. Science, 303,1506-8.
Church, R. M. (1984). Properties of the internal clock. Annals of the New York Academy of Sciences, 423, 566-582.
Fortin C. & Breton R. (1995). Temporal interval production and processing in working memory. Perception & Psychophysics, 57(2),203-15
Gibbon, J. (1977). Scalar expectancy theory and Weber's law in animal timing. Psychological Review, 84 (3), 279.
Gibbon, J., Church, R. M. & Meck, W. H. (1984). Scalar timing in memory. In J. Gibbon & L. Allan (Eds.), Timing and time perception (pp. 52-77). New York, NY: New York Academy of Sciences.
Gironell, A.; Rami, L.; Kulisevsky, J.; Garcia-Sanchez, C.,(2005). Lack of prefrontal repetitive transcranial magnetic stimulation effects in time production processing. European Journal of Neurology 12(11), 891-896.
Gu B. M., Meck W. H. (2011). “New perspectives on Vierordt's law: memory-mixing in ordinal temporal comparison tasks,” in Time and Time Perception 2010, LNAI 6789, eds Vatakis A., Esposito A., Cummins F., Papadelis G., Giagkou M., editors. (Berlin: Springer-Verlag;), pp 67–78.
Jeon S.Y., Han S.J. (2012) Improvement of the working memory and naming by transcranial direct current stimulation. Annals of Rehabilitation Medicine, 36, 585–595.
Jones C.R., Rosenkranz K., Rothwell J.C, Jahanshahi M. (2004). The right dorsolateral prefrontal cortex is essential in time reproduction: an investigation with repetitive transcranial magnetic stimulation. Experimental Brain Research 158,366–372.
Kane, Michael J.; Engle, Randall W. (2002). The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective. Psychonomic Bulletin & Review 9 (4): 637–71.
Koch, G., Oliveri, M., Carlesimo, G. A., Caltagirone, C. (2002). Selective deficit of time perception in a patient with right prefrontal cortex lesion. Neurology, 59, 1658-9.
Koch, G., Oliveri, M., Torriero, S., Caltagirone, C. (2003). Underestimation of time perception after repetitive transcranial magnetic stimulation. Neurology, 60,1844-6.
Koch, G., Oliveri, M., Brusa, L., Stanzione, P., Torriero, S. & Caltagirone, C. (2004).High-frequency rTMS improves time perception in Parkinson disease. Neurology,63, 2405–2406.
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (Eds.). (1997). International affective picture system (IAPS): Technical manual and affective ratings. University of Florida, Gainesville, FL.:
Lang N., Siebner H.R., Ward N.S., Lee L, Nitsche M.A., Paulus W., Rothwell J.C., Lemon R.N., Frackowiak R.S. (2005) How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? European Journal of Neuroscience 22, 495–504.
Lewis P.A., Miall R.C. (2006a). Remembering the time: a continuous clock. Trends in Cognitive Science, 10(9),401-6.
Lewis P.A., Miall R.C. (2006b). A right hemispheric prefrontal system for cognitive time measurement. Behavioral Processes, 71(2-3),226-34.
Lewis, P. A., Miall, R. C. (2003a) Distinct systems for automatic and cognitively controlled time measurement: evidence from neuroimaging. Current Opinion in Neurobiology, 13(2),250-5.
Lewis, P. A., Miall, R. C. (2003b) Brain activation patterns during measurement of sub- and supra-second intervals. Neuropsychologia, 41,1583-92.
Martin JLR, Barbanoj MJ, Schlaeper TE, Thompson E, Pe´rez V,Kulisevsky J (2003) Repetitive transcranial magnetic stimulation for the treatment of depression: Systematic review and meta-analysis. Br J Psychiatr 182:480–491.
Marié R.M., & Defer G.L. (2003). Working memory and dopamine: clinical and experimental clues. Current Opinion in Neurology, 2, S29-35.
Matell M.S. & Meck W.H. (2000) Neuropsychological mechanisms of interval timing behavior. Bioessays, 22(1), 94–103.
Meck, W. & Angell, K. E. (1992). Repeated administration of pyrithiamine leads to a proportional increase in the remembered duration of events. Psychobiology, 20, 39-46.
Meck W.H. (1986) Affinity for the dopamine D2 receptor predicts neuroleptic potency in decreasing the speed of an internal clock. Pharmacology Biochemistry and Behavior, 25, 1185–1189.
Meck, W.H.(1996) Neuropharmacology of timing and time perception. Cognitive Brain Research, 3,227-242.
Meck WH, Benson AM. (2002) Dissecting the brain’s internal clock: how frontal-striatal circuitry keeps time and shifts attention. Brain and Cognition, 48,195–211.
Mimura, M., Kinsbourne, M. & O’Connor, M. (2000).Time estimation by patients with frontal lesions and by Korsakoff amnesics. Journal of the International Neuropsychological Society., 6, 517–528.
Nitsche, M. A., & Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. Journal of Physiology, 527 (3), 633-639.
Nitsche M.A. (2002): Transcranial direct current stimulation: A new treatment for depression? Bipolar Disorder 4(1), 98 –99.
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A. (2008). Transcranial direct current stimulation: State of the art. Brain Stimulation, 1(3), 206-223.
Pastor M.A., Artieda J., Jahanshahi M., Obeso J.A. (1992). Time estimation and reproduction is abnormal in Parkinson's disease. Brain, 115(1),211-25.
Ribeiro, R.L. Pompeia, S & Bueno, OFA (2004) Normas brasileiras para o International Affective Picture System (IAPS): comunicação breve. R. Psiquiatr. RS, 26, 190-194.
Rosenkranz K., Nitsche M.A., Tergau F., Paulus W. (2000). Diminution of training-induced transient motor cortex plasticity by weak transcranial direct current stimulation in the human. Neuroscience Letters, 296(1),61-3.
Silton R. L., Miller G. A., Towers D. N., Engels A. S., Edgar J. C., Spielberg J. M., et al. (2010). The time course of activity in dorsolateral prefrontal cortex and anterior cingulate cortex during top-down attentional control. Neuroimage 50, 1292–1302.
Vallesi, A., Shallice, T., Walsh, V. (2007). Role of the prefrontal cortex in the foreperiod effect: TMS evidence for dual mechanisms in temporal preparation. Cerebral Cortex, 17(2), 466-74.
Vanderhasselt, M.A., De Readt R, Baeken C, Leyman L, D’haenen H. (2006). The influence of rTMS over the left dorsolateral prefrontal cortex on Stroop task performance. Exp. Brain Res.169, 279 – 282.
Vicario C.M., Martino, D., Koch, G. (2013). Temporal accuracy and variability in the left and right posterior parietal cortex. Neuroscience, 245,121–128.
Wager T.D. & Smith E.E. (2003). Neuroimaging studies of working memory: a meta-analysis. Cognitive, Affective, & Behavioral Neuroscience, 3(4), 255-274.
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