Keywords
coffee
Abstract
Summary: Introduction: Cancer encompasses several diseases arising from the uncontrolled growth of abnormal cells. Meanwhile, biological mechanisms have been studied by which certain components of coffee possess antioxidant,
2
antiangiogenic, and modulation properties of pathways regulating tumor growth. Objective: To compile, analyze, and summarize evidence on the effect of regular coffee consumption on gastric cancer incidence. Methods: An umbrella review will be conducted with a search for meta-analyses and systematic reviews in databases such as EMBASE, PubMed, Cochrane, and Lilacs from inception to February 2023; grey literature will be included. Article quality assessment will use the AMSTAR 2 tool (Assessing the methodological quality of systematic reviews). The search, selection, and data extraction will be independently performed by a pair of researchers, and discrepancies will be resolved through consensus. Discussion: Synthesizing evidence on the effect of regular coffee consumption on gastric cancer incidence will help address gaps in both knowledge and clinical practice.
Referencias
1. Barrios E, Garau M. Cáncer: magnitud del problema en el mundo y en Uruguay. Aspectos epidemiológicos. An Fa Med. 2017;4(1):9-46. https://doi.org/10.25184/anfamed2017.4.1.2
2. Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021 Aug 15;149(4):778-89. https://doi.org/10.1002/ijc.33588
3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209-49. https://doi.org/10.3322/caac.21660
4. Hernández G. Epidemiología del cáncer en Colombia: una transición que debemos conocer. Medicina. 2021;43(1):64-73. https://doi.org/10.56050/01205498.1586
5. Dranoff JA. Coffee consumption and prevention of cirrhosis: in support of the caffeine hypothesis. Gene Expr. 2017 Sep 12;18(1):1-3. https://doi.org/10.3727/105221617X15046391179559
6. Sartini M, Bragazzi NL, Spagnolo AM, Schinca E, Ottria G, Dupont C, et al. Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective studies. Nutrients. 2019 Mar 1;11(3):694. https://doi.org/10.3390/nu11030694
7. Kolb H, Kempf K, Martin S. Health effects of coffee: nechanism unraveled? Nutrients. 2020;12(6):1842. https://doi.org/10.3390/nu12061842
8. Sirotkin AV, Kolesarova A. The anti-obesity and health-promoting effects of tea and coffee. Physiol Res. 2021 Apr 1;70(2):161-8. https://doi.org/10.33549/physiolres.934674
9. Badoui N, Alba LH, Castillo JS, Peñaloza M, Gutiérrez V, Ibarra A. Regular coffee consumption and stroke risk. Rev Colomb Cardiol. 2021 Jul 1;28(4):389-96. https://doi.org/10.24875/RCCAR.M21000071
10. Lizarraga Dallo MA. Consideraciones actuales sobre el consumo de café en la actividad física y el deporte. Aten Primaria. 2009 Dec;41(12):698-701.
11. Pauwels EKJ, Volterrani D. Coffee consumption and cancer risk: an assessment of the health implications based on recent knowledge. Med Princ Pract. 2021;30(5):401-11. https://doi.org/10.1159/000516067
12. Bøhn SK, Blomhoff R, Paur I. Coffee and cancer risk, epidemiological evidence, and molecular mechanisms. Mol Nutr Food Res. 2014 May;58(5):915-30. https://doi.org/10.1002/mnfr.201300526
13. Strocchi G, Rubiolo P, Cordero C, Bicchi C, Liberto E. Acrylamide in coffee: what is known and what still needs to be explored. A review. Food Chem. 2022 Nov 1;393:133406. https://doi.org/10.1016/j.foodchem.2022.133406
14. Fakhri M, Fakheri H, Moosazadeh M, Ramezanpour M, Yousofpour M. The relationship between coffee consumption and the risk of gastric cancer; a systematic review and meta-analysis. Immunopathol Persa. 2023;9(1):e33406. https://doi.org/10.34172/ ipp.2022.33406
15. Xie Y, Huang S, He T, Su Y. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pac J Clin Nutr. 2016 Sep 1;25(3):578-88.
16. Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, et al. Coffee consumption and the risk of incident gastric cancer - A meta-analysis of prospective cohort studies. Nutr Cancer. 2016 Jan 2;68(1):40-7. https://doi.org/10.1080/01635581.2016.1115093
17. Aromataris E, Fernandez R, Godfrey C, Holly C, Khalil H, Tungpunkom P. JBI manual for evidence synthesis. JBI; 2024. https://doi.org/10.46658/JBIMES-24-08
18. Franco A, Sikalidis AK, Solís Herruzo JA. Cáncer de colon: influencia de la dieta y el estilo de vida. Rev Esp Enferm Dig [internet]. 2005;97(6). Disponible en: https://scielo.isciii.es/scielo.php?pid=S1130-01082005000600006&script=sci_arttext&tlng=es
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Wendy Nayibe Silva, Sergio Henao, Laura Daniela Chaves, Luz Helena Alba Talero, Nora Badoui Rodriguez, Maylin Peñaloza Parra