Keywords
central dogma
genetic transfer
polypeptide
RNA
How to Cite
Abstract
Reverse translation has been an enigmatic part in the Crick’s central dogma of molecular biology since 1950s. Described as the possibility of how protein could use itself as the information molecules that capable to be reverted back to the information in the nucleic acid nucleotides (or codon) or to replicate itself as its nucleic acid counterparts, DNA and RNA. Few studies in the past have attempted to theorize and to conduct in vitro experiment in order to test the possibilities of reverse translation as it believed to be existed back in the ancient Earth. The ideas are including the utilization of antigen determinant site and creation of a hammerhead ribozyme. At the end, the concept requires more follow-up studies as there are some constrains, including the stability of the protein peptide bonds, structural non-uniformity of protein R-groups and asymmetrical informational transfer. Now as bioinformatics rises as the growing branch of biology, it could serve as a tool to answer if reverse translation can be possible in the future that further can be useful to understand the protein-nucleic acid information symmetry in the ancient Earth. Moreover, reverse translation has potential applications in evolutionary biology, synthetic protein to nucleotide reversal and to improve the process in bioinformatics (e.g., via machine learning).
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