Opciones terapéuticas frente a especies de Candida resistentes a las equinocandinas

Andrea Patricia Cortés Hidalgo, Oscar Hernando Roa Dueñas, Yardany Rafael Méndez Fandiño, Carlos Arturo Álvarez Moreno

Resumen


Introducción: La infección por levaduras del género Candida representa la causa más común de infecciones fúngicas invasivas. Su alta incidencia y la creciente resistencia frente a los azoles y, recientemente, a las equinocandinas ha generado la necesidad de buscar nuevas alternativas farmacológicas. Esta revisión presenta las principales alternativas farmacológicas en estudio frente a Candida resistente a equinocandinas. Métodos: Se buscó literatura referente al tema en las bases de datos Bireme, Clinical Key, Embase, Cochrane, Lilacs, Pubmed y Scopus. Se incluyeron 15 artículos en esta revisión. Resultados: Se exploran diferentes alternativas, incluyendo el aumento de dosis de las equinocandinas, su combinación con otros medicamentos y nuevos compuestos en estudio. Conclusión: A pesar de que las infecciones por Candida resistente a equinocandinas aún representan un desafío, dos alternativas farmacológicas se presentan como promisorias: la combinación con medicamentos existentes como el diclofenaco y nuevos compuestos que se encuentran actualmente en fase II de estudios clínicos.

 


Palabras clave


equinocandinas; Candida; farmacorresistencia fúngica; antifúngicos

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Referencias


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DOI: http://dx.doi.org/10.11144/Javeriana.umed59-2.cand

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