Publicado nov 4, 2015


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Paula Alejandra Baldión

Jaime Eduardo Castellanos Parra



Los estudios sobre la citotoxicidad de los materiales de resina compuesta han demostrado que monómeros de resina dental, como el TEGDMA y HEMA, son capaces de modificar la respuesta celular, la actividad enzimática y la síntesis de ADN en diferentes líneas celulares. Los reportes en la literatura indican que los monómeros pueden actuar como estresores del medio ambiente celular al alterar el balance entre las especies oxidantes y las antioxidantes y afectar la homeostasis celular, lo cual puede traer como consecuencia daño celular. El propósito de esta revisión es presentar los hallazgos sobre la respuesta celular antioxidante frente a las especies reactivas de oxígeno producidas durante la exposición a los monómeros de resina, como un mecanismo de control altamente sofisticado enzimático y no enzimático. Conocer a profundidad los efectos celulares de los materiales dentales puede ayudar a ofrecer alternativas restauradoras que minimicen los efectos colaterales de las restauraciones poliméricas.


Cytotoxicity studies on composite resin materials have shown that dental resin monomers such as HEMA and TEGDMA are able to modify the cell response, metabolic activity, and DNA synthesis in various cell lines. Scientific reports indicate that monomers can act as cellular environment stressors by altering the balance between oxidants and antioxidants species, affecting cell homeostasis, which can result in cell damage. The purpose of this review is to present the findings on antioxidant cell response to reactive oxygen species produced during exposure to resin monomers, as a mechanism to control highly sophisticated enzymatic and non-enzymatic mechanisms involved in that response. Deeper knowledge about cell effects of dental materials can help provide restorative alternatives that minimize the side effects of polymer restorations.

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Cómo citar
Baldión, P. A., & Castellanos Parra, J. E. (2015). Estrés oxidativo inducido por los monómeros de resina dental. Respuesta celular / Oxidative Stress induced by Dental Resin Monomers. Cell Response. Universitas Odontologica, 33(71), 85–97.
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