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A series of 4,6-diaryl-2-aminopyrimidines was synthesized using a Biginelli-type three-component strategy optimized in conventional-heated reflux, in comparison to a non-conventional approach using monomode microwave reactor. Conventional heating protocols involved the use of organic solvents and general base catalysis, while microwave-assisted approach where performed following experimental protocols framed within the principles of green chemistry, by using aqueous medium and CaCl2 as catalyst. The study revealed that although conventional heating led to the main product in higher yields but at longer reaction times, the microwave strategy was accomplished in substantially shorter reaction times, with yields ranging from acceptable to good and efficiencies comparable to conventional heating methodologies.
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