Objective: Assessing the quality of life (cv) and its relationship with reintegration to work, depression and pain in people injured in traffic accidents. Methods: we evaluated reintegration to work, cv (sf-36); depression (phq-9); and pain (visual analog scale), in patients with moderate or severe trauma. Results: twelve months after the trauma 367 out of 461 patients reintegrated to work (81.4%). The patients that did not reintegrate had lower scores in the cv subscales, compared to the reference scores; those who did reintegrate to work had higher scores. We did not observe depression and phq-9 had a greater correlation with the emotional performance subscale of sf-36 in reintegrated people and with physical performance in those who did not reintegrate. cv was affected by the severity of the injuries and pain. Conclusion: cv is lower and was affected by the severity of the injuries and depression in patients who did not reintegrate to work.