Introduction: According to a different contextual and cultural knowledge society, knowledge transfer on public health is a possible issue nowadays. Methods: This implementation health research based on lessons learnt shows three cases of knowledge management supported by experience, common conditions and self-management social leadership processes developed in local spaces with stakeholders in Antioquia, Colombia through comparative analysis and documented scoping review. Results: Social Knowledge Management as a local mechanism on promotion the informed evidence on public health can be interchanged by observed spaces like knowledges networks, observatories, think tanks. Conclusion: Lessons learnt conduct in promote social participation processes for the collective building knowledge and concrete debates about equity for regional chances in Colombia.