Publicado oct 28, 2013



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Nelly Stella Roa Molina

Adriana Rodríguez Ciódaro

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Resumen

La caries dental es una enfermedad infecciosa multifactorial. Actualmente se estudia y comprende la mayoría de sus factores etiológicos, su progreso y su tratamiento preventivo y curativo; pero el conocimiento de cómo desencadena la respuesta inmune en humanos no se ha esclarecido. En este artículo se presenta un análisis del conocimiento sobre la respuesta inmune innata y adaptativa o específica frente a los microrganismos cariogénicos y sus antígenos más relevantes como factores de virulencia en caries dental. Los resultados muestran que la mayoría de los estudios se han realizado con Streptococcus mutans y sus antígenos; pero poco se conoce acerca de la respuesta frente a otros microrganismos cariogénicos. La respuesta proliferativa de las células T y el polimorfismo de la β-defensina-1 son los únicos elementos del sistema inmune que muestran algún papel en la resistencia o susceptibilidad a la enfermedad. Los otros elementos no pueden asociarse claramente con un papel protector en caries dental en humanos naturalmente sensibilizados.

 

Dental caries is a multifactorial infectious disease; currently, most of its etiological factors, progress and preventive and curative treatment are understood, but knowledge of how the immune response is triggered in humans has not been elucidated. This article analyzes the innate and adaptive or specific immune response against cariogenic microorganisms and their most relevant antigens as virulence factors in dental caries. Findings show that most of the studies have been performed with Streptococcus mutans and their antigens but little is known about the response to other cariogenic microorganisms. The proliferative response of T cells and polymorphism of β-defensin-1 are the only elements of the immune system that show some role in resistance or susceptibility to disease. The other elements cannot be associated clearly with a protective role in dental caries in naturally sensitized humans.

Keywords
References
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Cómo citar
Roa Molina, N. S., & Rodríguez Ciódaro, A. (2013). Inmunidad celular y humoral frente a microrganismos cariogénicos y sus factores de virulencia en caries dental en humanos naturalmente sensibilizados / Cellular and Humoral Immunity to Cariogenic Microorganisms and their Virulence Factors in Dental Caries. Universitas Odontologica, 32(69), 61–72. Recuperado a partir de https://revistas.javeriana.edu.co/index.php/revUnivOdontologica/article/view/SICI%3A%202027-3444%28201307%2932%3A69%3C61%3AICHFMC%3E2.0.CO%3B2-H
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