Vol. 54 No. 1 (2013), Original Articles
Vol. 54 No. 1 (2013)

Changes in Short Term Hippocampal Plasticity caused by a Peptide Designed and Synthesized based on the Structure of a Conotoxine

Original Articles
Published 2012-09-04
Alain Riveros Rivera
Pontificia Universidad Javeriana
Alejandra Guerrero
Fundación Santa Fe de Bogotá
PDF (Spanish)

Keywords

Conotoxins
toxinology
hippocampus

How to Cite

Changes in Short Term Hippocampal Plasticity caused by a Peptide Designed and Synthesized based on the Structure of a Conotoxine. (2012). Universitas Medica, 54(1), 10-25. https://doi.org/10.11144/Javeriana.umed54-1.mphc
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Abstract

Introduction: Designing bio-inspired devices or molecules has been a longstanding method supporting multiple advances in science and technology.

Objective: To test the potential effect of intraperitoneal administration of the bio-inspired peptide on short-term plasticity.

Materials and methods: Male rats in two groups (peptide treated and control) were used for registration of hippocampal field potentials from CA1, after paired stimuli in CA3 contra lateral area.

Results: Amplitude and slope of field potentials’, both before and after peptide administration, showed no changes in systemic factors (temperature and heart rate), but statistical significance in short term plasticity in small inter stimuli interval (40 to 80 ms).

Conclusion: The current research shows effects on paired pulse facilitation caused by peptide treatment, specifically on inter stimuli interval shorter.

PDF (Spanish)

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