Stereotactic ablative neurosurgery for addictions
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Ablative neurosurgery for addictions has been an object of investigation from different perspectives, in neurophysiology as well as in psychiatry. New knowledge and new evidence has proven the great importance that exists between different areas of the brain, in which functional activity alters during the development of the addictive phenomenon, that is why it is important to associate the anatomy and neurophysiology of the mesocorticolimbic system in order to develop new surgery techniques, for curative or palliative therapies regarding addiction disease.
In this present review about ablative neurosurgery in the nucleus accumbens, it is analyzed the anatomy and physiology of the limbic system particularly of the nucleus accumbens, and it will be discussed the advantages and limitations of current surgery techniques which may be taken in consideration for future advances in neurosurgical field.
núcleo accumbens, recompensa, agentes de dopamina, dopamina, técnicas de ablación, trastornos relacionados con sustancias, nucleus accumbens, reward, dopamine agents, dopamine, ablation techniques, substance-related disorders,
2. Hernández G. Abuso de sustancias; psiquiatría clínica, diagnóstico y tratamiento en niños, adolescentes y adultos. 3a. ed. Bogotá, Editorial Panamericana. Caps. 72-73. 2008;653-762.
3. Basar K, Sesia T, Groenewegen H, Steinbusch HW, Visser-Vandewalle V, Temel Y. Nucleus accumbens and impulsivity. Prog Neurobiol. Dec 2010;92(4):533-57.
4. Zahm D. An integrative neuroanatomical perspective on some subcortical substrates of adaptative responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev 54. 2008;120-7.
5. Jiménez F. Introducción a la neurocirugía psiquiátrica. Salud Mental. Ene-feb. 2006;29(1):3-12.
6. Wu H, Wang X, Chang CW, Li N, Li G, Hong J, Zhao W, Dong GG et al. Ablating the nucleus accumbens using stereotactic surgery for alleviating psychological dependence on alcohol. Department of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China. Neurosci Lett. Apr 5,2010;473(2):77-81. Epub 2010 Feb 13.
7. Okun M, Mann G. Deep brain stimulation in the internal capsule and nucleus accumbens region: Responses observed during active and sham programming. J Neurol Neurosurg Psychiatry. March 2007;78(3):310-4.
8. Perlmutter J, Mink J, Deep Brain Stimulation. Annual Review of Neuroscience. Departments of Neurology, Radiology, Physical Therapy and Anatomy & Neurobiology, Washington University School of Medicine, Washington University, St. Louis, Missouri. 29:229-57.