Vasoactive agents in sepsis: A critical review of the literature

Abstract

One of the essential therapeutic objectives in the approach to the septic patient is to impact early on the course of the underlying vasoplegia using medication with vasoactive potential. Multimodal management is of paramount importance, including appropriate monitoring techniques and personalized approaches, since excessive vasoconstriction can worsen multiple organ failure, and some inodilators may be deleterious to the hemodynamic profile of patients with septic shock. We offer an updated critical review of the evidence of vasoactive agents managing patients with sepsis.