Estudio de la inserción de ADNk de Trypanosoma cruzi en el genoma de pacientes con enfermedad de Chagas
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jul 17, 2010
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Resumen
La enfermedad de Chagas afecta cerca de 20 millones de personas y es una patología restringida al continente americano. Esta enfermedad de carácter crónico es causada por el parásito Trypanosoma cruzi del cual, en la actualidad se han definido dos poblaciones: Trypanosoma cruzi I y Trypanosoma cruzi II, con características particulares relacionadas con la distribución geográfica y el tipo de manifestaciones clínicas.
Keywords
Chagas disease, Trypanosoma cruzi, ADN, enfermedad de Chagas, Trypanosoma cruzi, ADN,
References
1. Gaunt M, Yeo M, Frame I. Mechanism of genetic exchange in American
Trypanosomes. Nature. 2003;421:936-9.
2. Junqueira A, Degrave W, Brandao A. Minicircle organization and diversity in Trypanosoma cruzi populations. Trend Parasitol. 2005;21:270-3.
3. Telleria J, Lafay B, Virreira M, Barnabé C, Tibayrenc M and Svoboda M. Trypanosoma cruzi: Sequence analysis of the variable region of kinetoplast minicircles. Experim Parasitol. 2006;114:279-88.
4. Baptista C, Vêncio R, Abdala S, Carranza J, Westenberger S, Silva M, et al. Differential transcription profiles in Trypanosoma cuzi associated with clinical forms of Chagas disease: Maxicircle NADH dehydrogenase subunit 7 gene truncation in asymptomatic patient isolates. Mol & Biochem Parasitol. 2006;150:238-48.
5. Teixeira AR, Argañaraz ER, Freitas LH, Zulmira J, Lacava G, Santana J, et al. Possible integration of Trypanosoma cruzi kDNA minicircles into the host cell genome by infection. Mutat Research. 1994;305:197-209.
6. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
7. Simoes-Barbosa A, Argañaraz E, Barros A, Nitz N, Teixeira A, Alves N, et al. Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon. Mem Inst Oswaldo Cruz. 2006;101:833-43.
8. Zafra G, Flórez O, Morillo C, Martín J, González CI. Inmunogenética de la enfermedad de Chagas. Salud UIS. 2006;38:76-7.
9. Ávila H, Pereira J, Thiemann O, De Paiva E, Degrave W, Morel C, et al.
Detection of Trypanosoma cruzi in blood specimens of chronic chagasic
patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis. J Clin Microbiol. 1993;31:2421-6.
10. Sanbrook Rl. Molecular cloning, a laboratory manual. Third edition. New York: CHSL Press; 2001. p. 110.
11. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
12. Roche Molecular Biochemicals DIG Application Manual for Filter
Hybridization. First edition. Manheim, Germany: Roche Diagnostics GmbH; 2000;45.
13. Tarleton R. Chagas disease: A role for autoimmunity? Trend Parasitol. 2003;19:447-51.
14. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
15. Gomes M, Macedo A, Vago A. Trypanosoma cruzi: Optimization of
polymerase chain reaction for detection in human blood. Exp Parasitol.
1998;88:28-33.
16. Tarleton R. Chagas disease: A role for autoimmunity? Trend Parasitol. 2003;19:447-51.
17. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
Trypanosomes. Nature. 2003;421:936-9.
2. Junqueira A, Degrave W, Brandao A. Minicircle organization and diversity in Trypanosoma cruzi populations. Trend Parasitol. 2005;21:270-3.
3. Telleria J, Lafay B, Virreira M, Barnabé C, Tibayrenc M and Svoboda M. Trypanosoma cruzi: Sequence analysis of the variable region of kinetoplast minicircles. Experim Parasitol. 2006;114:279-88.
4. Baptista C, Vêncio R, Abdala S, Carranza J, Westenberger S, Silva M, et al. Differential transcription profiles in Trypanosoma cuzi associated with clinical forms of Chagas disease: Maxicircle NADH dehydrogenase subunit 7 gene truncation in asymptomatic patient isolates. Mol & Biochem Parasitol. 2006;150:238-48.
5. Teixeira AR, Argañaraz ER, Freitas LH, Zulmira J, Lacava G, Santana J, et al. Possible integration of Trypanosoma cruzi kDNA minicircles into the host cell genome by infection. Mutat Research. 1994;305:197-209.
6. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
7. Simoes-Barbosa A, Argañaraz E, Barros A, Nitz N, Teixeira A, Alves N, et al. Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human host cells via LINE-1 retrotransposon. Mem Inst Oswaldo Cruz. 2006;101:833-43.
8. Zafra G, Flórez O, Morillo C, Martín J, González CI. Inmunogenética de la enfermedad de Chagas. Salud UIS. 2006;38:76-7.
9. Ávila H, Pereira J, Thiemann O, De Paiva E, Degrave W, Morel C, et al.
Detection of Trypanosoma cruzi in blood specimens of chronic chagasic
patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis. J Clin Microbiol. 1993;31:2421-6.
10. Sanbrook Rl. Molecular cloning, a laboratory manual. Third edition. New York: CHSL Press; 2001. p. 110.
11. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
12. Roche Molecular Biochemicals DIG Application Manual for Filter
Hybridization. First edition. Manheim, Germany: Roche Diagnostics GmbH; 2000;45.
13. Tarleton R. Chagas disease: A role for autoimmunity? Trend Parasitol. 2003;19:447-51.
14. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
15. Gomes M, Macedo A, Vago A. Trypanosoma cruzi: Optimization of
polymerase chain reaction for detection in human blood. Exp Parasitol.
1998;88:28-33.
16. Tarleton R. Chagas disease: A role for autoimmunity? Trend Parasitol. 2003;19:447-51.
17. Nitz N, Gomes C. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. Cell. 2004;118:175-86.
Cómo citar
Chacín, C., & Gonzalo Torres, R. (2010). Estudio de la inserción de ADNk de Trypanosoma cruzi en el genoma de pacientes con enfermedad de Chagas. Universitas Medica, 51(4), 371–384. https://doi.org/10.11144/Javeriana.umed51-4.eiat
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