Arquivos suplementares
Palavras-chave
antifibrinolítico
cirurgia oral
complicações
discrasias sanguíneas
hemorragia
odontologia
procedimentos cirúrgicos bucais
terapêutica
terapia de drogas
Como Citar
Resumo
Antecedentes: O ácido tranexâmico (ATX) é um sintético da lisina que inibe a fibrinólise ao reduzir a conversão de plasminogênio em fibrinolisina, o que favorece a preservação do coágulo formado na área operada e reduz o risco de sangramento. Eventualmente se utiliza como complemento em cirurgia oral. Objetivo: Analisar a evidência sobre a eficácia da hemostasia, dosagem adequada, margem de segurança, benefícios e evolução pós-operatória do ATX usado na cirurgia bucal. Métodos: A revisão sistemática se estruturou a partir de uma árvore de busca (PubMed, Google Scholar, ProQuest e Scopus), com as palavras-chave e o conector booleano: Ácido Tranexâmico Y Cirurgia Oral. A busca é limitada aos idiomas inglês, português e espanhol; artigos de acesso aberto; revisões sistemáticas, metanálisis, ensaios clínicos aleatórios e informes de casos. Estabeleceu uma seleção secundária a partir do título e resumiu os artigos de acordo com o objetivo do estudo. Resultados: A literatura relata uma eficácia de 80% de ATX para reduzir o risco de sangramento durante e após os procedimentos cirúrgicos, o que otimiza os procedimentos. Conclusões: O ATX tópico ou intravenoso em dose não superior a 20 mg demonstrou ser eficaz para reduzir o risco de sangramento em cirurgia oral.
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Copyright (c) 2023 Silvana Graciela Armijos Idrovo, Luis Adrián Pacheco Carabajo, Juan Martín Pesantez Alvarado, Milton Fabricio Lafebre Carrasco