Publicado jul 3, 2012



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María Claudia Esquiva Mercado

Paola Andrea Acevedo Toro

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Resumen

La hepcidina es una hormona peptídica, producida en el hígado y considerada un regulador del metabolismo del hierro. Su regulación está dirigida a la absorción intestinal del hierro y a la función de la ferroportina dentro de la célula, a fin de mantener un balance entre el consumo y las reservas de hierro. Esta hormona, a su vez, está regulada por procesos inflamatorios, estados de anemia ferropénica, actividad hematopoyética y algunas vías de señalización como SMAD, STAT y JAK. En estas vías interviene una proteína de membrana llamada hemojuvelina, la cual actúa como un correceptor de la proteína morfogenética ósea, cuya función es inducir el gen de transcripción de la hepcidina mediante la vía SMAD1/5/8-SMAD4. Debido a la asociación de la hemojuvelina con la expresión de la hepcidina y la relación de esta última con procesos inflamatorios y regulación del metabolismo del hierro, se han propuesto algunas técnicas para la determinación de ambas proteínas como Elisa, Dotblot, inmunoensayos y SELDI-TOF MS. 

Keywords

Hepcidin, hemojuvelin, iron metabolism, hepcidina, hemojuvelina, metabolismo del hierro,

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Cómo citar
Esquiva Mercado, M. C., & Acevedo Toro, P. A. (2012). Hepcidina: su interacción con la hemojuvelina y su aporte en el diagnóstico de las enfermedades relacionadas con el metabolismo del hierro. Universitas Medica, 53(4), 382–394. https://doi.org/10.11144/Javeriana.umed53-4.hiha
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