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Objective: To evaluate the immunomodulatory effect of sertraline (SRT) and sertraline included in β-cyclodextrin (LF) in human dendritic cells (DCs) generated in vitro from monocytes on phenotype markers and cytokine production. Materials and Methods: CD14 + monocytes from peripheral blood mononuclear cells were isolated and differentiated to DCs. DCs were subsequently pretreated with LF or SRT for one hour. Finally DCs were matured with lipopolysaccharide (LPS) for 24 hours and the CDs phenotype and the levels of cytokines in the culture supernatants were analyzed. Results: No change on the phenotype of the DCs matured with LPS in the absence or presence of the SRT was observed. Likewise, there was no variation in cytokine production. Conclusion: SRT or not including β-cyclodextrin does not affect the phenotype and secretion of LPS-treated DCs.
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