Publicado May 25, 2016



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Maira Moreno Castillo

Julian Ramírez Cheyne

Sebastian Medina Cárdenas

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Resumen

Introducción: Evidencias moleculares y celulares muestran mecanismos comunes entre la migración de las células de la cresta neural (CCN) y la metástasis en las células cancerosas. La delaminación de las CCN implica una transición epitelio-mesénquima (TEM) parcial o completa, la cual es regulada por una compleja red de factores de transcripción. Métodos: Se realizó una revisión de la literatura acerca de las similitudes existentes entre los procesos de delaminación de las CCN y la progresión tumoral.
Resultados y conclusiones: El proceso de TEM es clave tanto en la morfogénesis
embrionaria como en la progresión de tumores primarios hacia tumores metastásicos, por lo que comprender cómo se dan los cambios que conducen a la migración celular constituye una importante herramienta para encaminar futuras alternativas terapeúticas en neurocristopatías y cáncer.

Keywords

cresta neural, cáncer, metástasisNeural crest, cancer, metastasis

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Cómo citar
Moreno Castillo, M., Ramírez Cheyne, J., & Medina Cárdenas, S. (2016). Transición epitelio-mesénquima y migración celular en células de la cresta neural y células metastásicas de carcinomas. Revisión de la literatura. Universitas Médica, 57(1), 83-107. https://doi.org/10.11144/Javeriana.umed57-1.temm
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