Trace Elements and Bipolar Affective Disorder
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Aug 31, 2017
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Abstract
Introduction: Trace elements or trace mineral are dietary minerals found in few amounts in the human body, they play important roles in vital functions, which gives them their significance. Excess or deficit levels of trace elements such as zinc, lithium, copper and lead may be involved in the development of bipolar disease; There is a possible relation among imbalances of trace elements and the stages of Bipolar Disease. Methods: Parallel search made by two reviewers on the data basis of Ovid, Pubmed, SciELO, and Cochrane. Results: A total of 47 articles published between 1998-2015 were found, finally 12 full text articles were evaluated. Conclusions: Available literatures suggest an association among elevated levels of zinc in mania and low levels in depressive phase in patients with bipolar disorder. No significant association with other trace elements was found. Further studies are required with larger numbers of patients to establish these associations.
Keywords
bipolar affective disorder, trace elements, lithium, zinc.trastorno afectivo bipolar, elementos traza, litio, zinc
References
1. Pradeep AS, Naga Raju GJ, Sattar SA, Sarita P, Prasada Rao AD, Ray DK, et al. Trace elemental distribution in the scalp hair of bipolars using PIXE technique. Med Hypotheses. 2014;82(4):470-7. doi: http://dx.doi.org/10.1016/j.mehy.2014.01.028
2. Jung KI, Ock SM, Chung JH, Song CH. Associations of serum Ca and Mg levels with mental health in adult women without psychiatric disorders. Biol Trace Elem Res. 2010;133(2):153-61.
3. Bravo MF, Lahera G, Lalucat L, Fernández-Liria A. Guía de práctica clínica sobre el trastorno bipolar: tratamiento farmacológico y psicosocial. Med Clin (Barc) [internet]. 2013;141(7):305.e1-305.e10. Disponible en: http://www.sciencedirect.com/science/article/pii/S0025775313003977
4. Ministerio de Salud y Protección Social. Análisis de situación de salud: Colombia, 2013 [internet]. Bogotá: Ministerio; 2014. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/PSP/ASIS %2024022014.pdf
5. World Health Organization. Global status report on noncommunicable diseases 2014 [internet]. 2014. Disponible en: http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf?ua=1
6. Flores CR, Puga MP, Wrobel K, Garay Sevilla ME, Wrobel K. Trace elements status in diabetes mellitus type 2: Possible role of the interaction between molybdenum and copper in the progress of typical complications. Diabetes Res Clin Pract. 2011;91(3):333-41.
7. Natural Medicines. Bipolar disorder. 2016.
8. Mustak MS, Rao TSS, Shanmugavelu P, Sundar NMS, Menon RB, Rao RV, et al. Assessment of serum macro and trace element homeostasis and the complexity of inter-element relations in bipolar mood disorders. Clin Chim Acta. 2008;394(1-2):47-53.
9. Solomon DA, Leon AC, Coryell WH, Li C, Fiedorowicz JG, Boyken ML. NIH Public Access Duration of Mood Episodes. ArchGenPsychiatry. 2010;67(4):339-47.
10. González-Estecha M, Trasobares EM, Tajima K, Cano S, Fernández C, López JL, et al. Trace elements in bipolar disorder. J Trace Elem Med Biol. 2011;25(suppl. 1):78-83.
11. Clay HB, Sillivan S, Konradi C. Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci. 2011;29(3):311–24. doi: http://dx.doi.org/10.1016/j.ijdevneu.2010.08.007
12. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11(6):851-76. doi: 10.1017/S1461145707008401
13. García-Blanco AC, Sierra P, Livianos L. Nosología, epidemiología y etiopatogenia del trastorno bipolar: últimas aproximaciones. Psiquiatr Biol. 2014;21(3):89-94.
14. Khouzam HR, Singh F. Bipolar disorder: historic perspective, current pharmacologic treatment options and a review of quetiapine. Expert Rev Neurother. 2006;6(2):131-44.
15. Shulman KI, Tohen M. Unipolar mania reconsidered: Evidence from an elderly cohort. Br J Psychiatry. 1994;164(apr.):547-9.
16. Mitchell PB, Malhi GS. Bipolar depression: Phenomenological overview and clinical characteristics. Bipolar Disord. 2004;6(6):530-9.
17. Dafflon M, Décosterd LA, Biollaz J, Preisig M, Dufour H, Buclin T. Trace lithium in mood disorders. J Affect Disord. 1999;54(1-2):199-203.
18. Grönli O, Kvamme JM, Friborg O, Wynn R. Zinc deficiency is common in several psychiatric disorders. PLoS One. 2013;8(12):6-13.
19. Nowak G, Szewczyk B. Mechanisms contributing to antidepressant zinc actions. Pharmacol Reports. 2002;54(6):58792.
20. Paoletti P, Vergnano AM, Barbour B, Casado M. Zinc at glutamatergic synapses. Neuroscience. 2009;158(1):126–36. doi: http://dx.doi.org/10.1016/j.neuroscience.2008.01.061
21. Schöpfer J, Schrauzer GN. Lithium and other elements in scalp hair of residents of Tokyo Prefecture as investigational predictors of suicide risk. Biol Trace Elem Res. 2011;144(1-3):418-25.
22. Shiotsuki I, Terao T, Ishii N, Takeuchi S, Kuroda Y, Kohno K, et al. Trace lithium is inversely associated with male suicide after adjustment of climatic factors. J Affect Disord. 2016;189:282–6. doi: http://dx.doi.org/10.1016/j.jad.2015.09.070
23. Friedlich AL. Neocortical levels of lithium are increased in bipolar disorder. Mol Psychiatry. 2012;17(1):3-4.
24. Siwek M, Sowa-Kućmab M, Styczeń K, Szewczyk B, Reczyński W, Misztak P, et al. Decreased serum zinc concentration during depressive episode in patients with bipolar disorder. J Affect Disord. 2016;190:272-7.
25. Siwek M, Szewczyk B, Dudek D, Styczeñ K, Sowa-Kuæma M, Mlyniec K, et al. Zinc as a marker of affective disorders. Pharmacol Reports. 2013;65(6):1512-8.
26. Carta MG, Sorbello O, Moro MF, Bhat KM, Demelia E, Serra A, et al. Bipolar disorders and Wilson’s disease. BMC Psychiatry. 2012;12:53. doi: 10.1186/1471-244X-12-52.
27. Terao T. Is lithium potentially a trace element? World J Psychiatry. 2015;5(1):1-3.
28. Aliasgharpour M, Farzami M. Trace elements in human nutrition: A review. Int J Med Invest. 2013;2(3):115-28.
29. Wada O. What are Trace Elements ? — Their deficiency and excess states. JPN Med Assoc J. 2004;47(5):351.
30. Vasudevaraju P, Bharathi TJ, Shamasundar NM, Subba Rao K, Balaraj BM, et al. New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions. Indian J Psychiatry. 2010;52(2):140-4.
31. Menon AV, Chang J, Kim J. Mechanisms of divalent metal toxicity in affective disorders. Toxicology. 2016;339:58-72. doi: http://dx.doi.org/10.1016/j.tox.2015.11.001
2. Jung KI, Ock SM, Chung JH, Song CH. Associations of serum Ca and Mg levels with mental health in adult women without psychiatric disorders. Biol Trace Elem Res. 2010;133(2):153-61.
3. Bravo MF, Lahera G, Lalucat L, Fernández-Liria A. Guía de práctica clínica sobre el trastorno bipolar: tratamiento farmacológico y psicosocial. Med Clin (Barc) [internet]. 2013;141(7):305.e1-305.e10. Disponible en: http://www.sciencedirect.com/science/article/pii/S0025775313003977
4. Ministerio de Salud y Protección Social. Análisis de situación de salud: Colombia, 2013 [internet]. Bogotá: Ministerio; 2014. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/PSP/ASIS %2024022014.pdf
5. World Health Organization. Global status report on noncommunicable diseases 2014 [internet]. 2014. Disponible en: http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf?ua=1
6. Flores CR, Puga MP, Wrobel K, Garay Sevilla ME, Wrobel K. Trace elements status in diabetes mellitus type 2: Possible role of the interaction between molybdenum and copper in the progress of typical complications. Diabetes Res Clin Pract. 2011;91(3):333-41.
7. Natural Medicines. Bipolar disorder. 2016.
8. Mustak MS, Rao TSS, Shanmugavelu P, Sundar NMS, Menon RB, Rao RV, et al. Assessment of serum macro and trace element homeostasis and the complexity of inter-element relations in bipolar mood disorders. Clin Chim Acta. 2008;394(1-2):47-53.
9. Solomon DA, Leon AC, Coryell WH, Li C, Fiedorowicz JG, Boyken ML. NIH Public Access Duration of Mood Episodes. ArchGenPsychiatry. 2010;67(4):339-47.
10. González-Estecha M, Trasobares EM, Tajima K, Cano S, Fernández C, López JL, et al. Trace elements in bipolar disorder. J Trace Elem Med Biol. 2011;25(suppl. 1):78-83.
11. Clay HB, Sillivan S, Konradi C. Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci. 2011;29(3):311–24. doi: http://dx.doi.org/10.1016/j.ijdevneu.2010.08.007
12. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11(6):851-76. doi: 10.1017/S1461145707008401
13. García-Blanco AC, Sierra P, Livianos L. Nosología, epidemiología y etiopatogenia del trastorno bipolar: últimas aproximaciones. Psiquiatr Biol. 2014;21(3):89-94.
14. Khouzam HR, Singh F. Bipolar disorder: historic perspective, current pharmacologic treatment options and a review of quetiapine. Expert Rev Neurother. 2006;6(2):131-44.
15. Shulman KI, Tohen M. Unipolar mania reconsidered: Evidence from an elderly cohort. Br J Psychiatry. 1994;164(apr.):547-9.
16. Mitchell PB, Malhi GS. Bipolar depression: Phenomenological overview and clinical characteristics. Bipolar Disord. 2004;6(6):530-9.
17. Dafflon M, Décosterd LA, Biollaz J, Preisig M, Dufour H, Buclin T. Trace lithium in mood disorders. J Affect Disord. 1999;54(1-2):199-203.
18. Grönli O, Kvamme JM, Friborg O, Wynn R. Zinc deficiency is common in several psychiatric disorders. PLoS One. 2013;8(12):6-13.
19. Nowak G, Szewczyk B. Mechanisms contributing to antidepressant zinc actions. Pharmacol Reports. 2002;54(6):58792.
20. Paoletti P, Vergnano AM, Barbour B, Casado M. Zinc at glutamatergic synapses. Neuroscience. 2009;158(1):126–36. doi: http://dx.doi.org/10.1016/j.neuroscience.2008.01.061
21. Schöpfer J, Schrauzer GN. Lithium and other elements in scalp hair of residents of Tokyo Prefecture as investigational predictors of suicide risk. Biol Trace Elem Res. 2011;144(1-3):418-25.
22. Shiotsuki I, Terao T, Ishii N, Takeuchi S, Kuroda Y, Kohno K, et al. Trace lithium is inversely associated with male suicide after adjustment of climatic factors. J Affect Disord. 2016;189:282–6. doi: http://dx.doi.org/10.1016/j.jad.2015.09.070
23. Friedlich AL. Neocortical levels of lithium are increased in bipolar disorder. Mol Psychiatry. 2012;17(1):3-4.
24. Siwek M, Sowa-Kućmab M, Styczeń K, Szewczyk B, Reczyński W, Misztak P, et al. Decreased serum zinc concentration during depressive episode in patients with bipolar disorder. J Affect Disord. 2016;190:272-7.
25. Siwek M, Szewczyk B, Dudek D, Styczeñ K, Sowa-Kuæma M, Mlyniec K, et al. Zinc as a marker of affective disorders. Pharmacol Reports. 2013;65(6):1512-8.
26. Carta MG, Sorbello O, Moro MF, Bhat KM, Demelia E, Serra A, et al. Bipolar disorders and Wilson’s disease. BMC Psychiatry. 2012;12:53. doi: 10.1186/1471-244X-12-52.
27. Terao T. Is lithium potentially a trace element? World J Psychiatry. 2015;5(1):1-3.
28. Aliasgharpour M, Farzami M. Trace elements in human nutrition: A review. Int J Med Invest. 2013;2(3):115-28.
29. Wada O. What are Trace Elements ? — Their deficiency and excess states. JPN Med Assoc J. 2004;47(5):351.
30. Vasudevaraju P, Bharathi TJ, Shamasundar NM, Subba Rao K, Balaraj BM, et al. New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions. Indian J Psychiatry. 2010;52(2):140-4.
31. Menon AV, Chang J, Kim J. Mechanisms of divalent metal toxicity in affective disorders. Toxicology. 2016;339:58-72. doi: http://dx.doi.org/10.1016/j.tox.2015.11.001
How to Cite
Cruz Ramírez, K. V., Benavides Solarte, M. F., & Gómez Restrepo, C. (2017). Trace Elements and Bipolar Affective Disorder. Universitas Medica, 58(2). https://doi.org/10.11144/Javeriana.umed58-2.traz
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