La sertralina incluida en la β-ciclodextrina no induce un perfil tolerogénico en células dendríticas derivadas de monocitos
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feb 7, 2017
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Resumen
Objetivo: Evaluar el efecto inmunomodulador de la sertralina (SRT) y la sertralina
incluida en la β-ciclodextrina (LF) en células dendríticas humanas (CD) generadas in
vitro a partir de monocitos sobre marcadores de fenotipo y la producción de citocinas.
Materiales y métodos: Se aislaron monocitos CD14+ de células mononucleares de
sangre periférica y se diferenciaron a CD; posteriormente, se pretrataron con SRT o
LF durante una hora. Finalmente, las CD se maduraron con lipopolisacárido (LPS)
durante 24 horas y se analizó el fenotipo de las CD y las concentraciones de citocinas
en los sobrenadantes de cultivo. Resultados: No se observaron cambios al comparar
el fenotipo de las CD maduradas con LPS en ausencia o presencia de la SRT. Así
mismo, no hubo variación en cuanto a la producción de citocinas. Conclusión: La
SRT incluida o no en la β-ciclodextrina no afecta el fenotipo y la secreción de las CD
tratadas con LPS.
Keywords
dendritic cells, sertraline, β-cyclodextrincélulas dendríticas, sertralina, β-ciclodextrina
References
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2. Passos JJ, De Sousa FB, Lula IS, Barreto EA, Lopes JF, De Almeida WB, Sinisterra RD. Multi-equilibrium system based on sertraline and β-cyclodextrin supramolecular complex in aqueous solution. Int J Pharm. 2011;421(1):24-33. doi: 10.1016/j.ijpharm.2011.09.026
3. Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future. Nat Rev Drug Discov. 2004;3:1023-35.
4. Furtado M, Katzman MA. Examining the role of neuroinflammation in major depression. Psychiat Res. 2015;229:27-36.
5. Lesch KP. Gene-environment interaction and the genetics of depression. J Psychiat Neurosci. 2004;29:174.
6. Felger JC, Lotrich FE. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience. 2013;246:199-229.
7. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67(5):446-57. doi: 10.1016/j.biopsych.2009.09.033
8. Branco-de-Almeida LS, Franco GC, Castro ML, Dos Santos JG, Anbinder AL, Cortelli SC, et al. Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis. J Periodontol. 2012;83(5):664-71. doi: 10.1902/jop.2011
9. Tynan RJ, Weidenhofer J, Hinwood M, Cairns MJ, Day TA, Walker FR. A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun. 2012;26:469-79. doi: 10.1016/j.bbi.2011.12.011
10. Daniele S, Da Pozzo E, Zappelli E, Martini C. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-KB, p38 and JNK. Cell Signal. 2015;27:1609-29.
11. Franco R, Pacheco R, Lluis C, Ahern GP, O´Connell PJ. The emergence of neurotransmitters as immune modulators. Trends Immunol. 2007;28:400-7.
12. Mössner R, Lesch K-P. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav Immun. 1998;12:249-71.
13. O’Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP. A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood. 2006;107(3):1010-7.
14. Idzko M, Panther E, Stratz C, Müller T, Bayer H, Zissel G, et al. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunol. 2004;172(10):6011-9.
15. Muller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One. 2009;4(7):e6453. doi: 10.1371/journal.pone.0006453
16. Katoh N, Soga F, Nara T, Tamagawa-Mineoka R, Nin M, Kotani H, et al. Effect of serotonin on the differentiation of human monocytes into dendritic cells. Clin Exp Immunol. 2006;146(2):354-61.
17. Ahern GP. 5-HT and the immune system. Curr Opin Pharmacol. 2011;11:29-33.
18. Branco-de-Almeida LS, Kajiya M, Cardoso CR, Silva MJ, Ohta K, Rosalen PL, et al. Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes. FEMS Immunol Med Microbiol. 2011;62(3):283-94. doi: 10.1111/j.1574-695X.2011.00816.x
19. Nikolic T, Roep BO. Regulatory multitasking of tolerogenic dendritic cells-lessons taken from vitamin d3-treated tolerogenic dendritic cells. Front Immunol. 2013;4:113. doi: 10.3389/fimmu.2013.00113
20. Steinman RM. Dendritic cells: understanding immunogenicity. Eur J Immunol. 2007;37:S53-60.
21. Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K et al. Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces th2 cell and t follicular helper cell responses to the coadministered antigen. J Immunol. 2015;194(6):2673-82. doi: 10.4049/jimmunol.1402027
22. Lee JS, Jung ID, Lee CM, Noh KT, Park JW, Son KH, et al. Venlafaxine inhibits the development and differentiation of dendritic cells through the regulation of P-glycoprotein. Int Immunopharmacol. 2011;11(9):1348-57. doi: 10.1016/j.intimp.2011.04.019
Cómo citar
Muñoz, S., & Rodríguez, L. S. (2017). La sertralina incluida en la β-ciclodextrina no induce un perfil tolerogénico en células dendríticas derivadas de monocitos. Universitas Medica, 57(4), 438–449. https://doi.org/10.11144/Javeriana.umed57-4.sert
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