Publicado oct 19, 2017



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Daniela Troncoso

Ithzayana Madariaga Perpiñan

Sergio Andrés Aldana Mancera

Angélica María Herreño Pachón

Viviana Paola Chaparro Ramírez

Mónica Lorena Molina Camargo

Laura Rey Vargas

Andrea Carolina Ramírez Rodríguez

Christian Fernando Montoya Estupiñan

Andrea Valderrama Álvarez

Alejandra Cañas Arboleda

Adriana Patricia Rojas Moreno

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Resumen

Resumen


La transición epitelio mesénquima (EMT) es un proceso compuesto de diferentes fases, donde una célula epitelial adquiere un fenotipo mesenquimal. Dentro de los cambios involucrados se encuentran: pérdida de la polaridad celular, adquisición de una capacidad migratoria, capacidad invasora, resistencia a la apoptosis y aumento en la producción de componentes de la matriz extracelular. Todos estos cambios ocurren como una consecuencia de la activación y represión de genes involucrados con rutas de señalización específicas relacionadas con este evento. La EMT está relacionada con procesos fisiológicos y patológicos como el cáncer. Consta de tres fases: una de células no migratorias, células premigratorias y células migratorias; cada una de ellas producto de diferentes señales intra o extracelulares, factores de transcripción (TGF-B, Snail, TWIST, Sox, Slug, ZEB1, entre otras) y proteínas involucradas (E-cadherina, integrina, vimentina, ocludinas y claudinas). 

Keywords

transition, epithelial, mesenchymal, physiological, pathological, transcription factorstransición, epitelial, mesenquimal, fisiológicos, patológicos, factores de transcripción

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Cómo citar
Troncoso, D., Madariaga Perpiñan, I., Aldana Mancera, S. A., Herreño Pachón, A. M., Chaparro Ramírez, V. P., Molina Camargo, M. L., Rey Vargas, L., Ramírez Rodríguez, A. C., Montoya Estupiñan, C. F., Valderrama Álvarez, A., Cañas Arboleda, A., & Rojas Moreno, A. P. (2017). Transición epitelio mesénquima: de lo molecular a lo fisiológico. Universitas Medica, 58(4). https://doi.org/10.11144/Javeriana.umed58-4.temm
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