Heat Shock Protein 70 expression in well- and poorly-differentiated oral Squamous Cell Carcinoma of oral cavity
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BACKGOUND: When studying the immune response against cancer, the Heat Shock Proteins (HSP) have been related to the tumorous growing by inducing an immune response in the host. Among the HSP families, which have shown a strong association with cancer, HSP70 can be identified; it has exhibited a different expression in some kinds of tumors. For instance, in breast and colon rectal carcinomas, a low differentiation and poor prognosis were observed, but a good prognosis in kidney tumor was found. However, alterations in the expression of HSP70 in oral cavity injuries have received little attention. OBJECTIVE: To determine the expressions of HSP70 in well differentiated and poorly-differentiated Squamous Cell Carcinomas (SCC) of oral cavity, in order to correlate its degree of expression with its cellular differentiation. METHODS: By using immunohistochemical techniques, the expression of the HSP70 in 10 well differentiated and 10 poorly differentiated SCC biopsies of oral cavity were analyzed. RESULTS: A high expression of HSP70 was observed in 7 of 10 well differentiated SCC biopsies and a mild expression in the rest of them. In the poorly differentiated SCC, there was not expression of HSP70. CONCLUSIONS:The lack of expression of HSP70 in poorly differentiated SCC could suggestan elusion system of the immune response, due to its degree of indifferentiation.
Oral squamous cell carcinoma, heat shock proteins, HSP70, oral pathologyCarcinoma escamocelular oral, proteínas de choque térmico, HSP70, patología oral
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