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Adriana Patricia Rojas Moreno

Ricardo Elias Bruges

Alejandra Cañas Arboleda

Luis Fernando Jaramillo García

Resumen

En el mundo, el cáncer de pulmón es la principal causa de muerte por neoplasias, yello se debe a que su detección ocurre en los estadios más avanzados de la enfermedad(III o IV). Dentro de los factores de riesgo descritos en la generación de este cáncerse encuentran el consumo de tabaco, la inhalación y posterior acumulación de radón yasbestos en el tejido pulmonar, la contaminación ambiental y la presencia de alteracionesgenéticas y de factores epigenéticos que regulan la expresión o represión de genesinvolucrados con el desarrollo tumoral. Los mecanismos de regulación epigenética quepueden intervenir en la progresión tumoral son: la metilación del ADN, la modificacióncovalente de histonas y la presencia de ARN no codificantes. En las diferentes etapasde progresión tumoral se ha descrito la participación de los mecanismos epigenéticoscomo reguladores de procesos relacionados con proliferación, transición epiteliomesénquima,metástasis, apoptosis, entre otros. Esta revisión de tema se enfoca endescribir el papel de la epigenética en la progresión tumoral pulmonar y plantea laimportancia de ampliar el conocimiento en esta disciplina con fines de diagnóstico ytratamiento.

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Keywords

represión epigenética, metilación de ADN, código de histonas, cáncer de pulmón, cromatina.

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Cómo citar
Rojas Moreno, A., Bruges, R., Cañas Arboleda, A., & Jaramillo García, L. (2017). Regulación epigenética en cáncer de pulmón: implicaciones para el clínico. Universitas Medica, 57(3), 332-347. https://doi.org/10.11144/Javeriana.umed57-3.recp
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