colgajos libres, lesión isquemia reperfusión, colgajos, apoptosis, necrosis, microcirugíaischemia reperfusion injury, free flaps, skin flap, cell apoptosis, necrosis, microsurgery

1. Kumar V, Abbas A, Aster J. Cell injury, cell death and adaptations. En: Robbins basic pathology. 10.ª ed. Filadelfia: Elsevier; 2020. p. 7-34.

2. van den Heuvel MG, Buurman WA, Bast A, van der Hulst RR. Review: ischaemia-reperfusion injury in flap surgery. J Plast Reconstr Aesthet Surg. 2009 Jun;62(6):721-6. https://doi.org/10.1016/j.bjps.2009.01.060

3. Baue AE, McClerkin WW. A study of shock: acidosis and declamping phenomenon. Ann Surg. 1965 Jan;161(1):41-5. https://doi.org/10.1097/00000658-196501000-00006

4. Vetto RM, Brant B. Control of declamping shock. Am J Surg. 1968 Aug;116(2):273-9. https://doi.org/10.1016/0002-9610(68)90504-7

5. Cerra FB, Lajos TZ, Montes M, Siegel JH. Hemorrhagic infarction: a reperfusion injury following prolonged myocardial ischemic anoxia. Surgery. 1975 Jul;78(1):95-104. PMID: 1138403.

6. Wang WZ, Baynosa RC, Zamboni WA. Update on ischemia-reperfusion injury for the plastic surgeon: 2011. Plast Reconstr Surg. 2011 Dec;128(6):685e-692e. https://doi.org/10.1097/PRS.0b013e318230c57b

7. May JW Jr, Chait LA, O'Brien BM, Hurley JV. The no-reflow phenomenon in experimental free flaps. Plast Reconstr Surg. 1978 Feb;61(2):256-67. https://doi.org/10.1097/00006534-197802000-00017

8. Neglén P, Jabs CM, Eklöf B. Plasma metabolic disturbances and reperfusion injury following partial limb ischaemia in man. Eur J Vasc Surg. 1989 Apr;3(2):165-72. https://doi.org/10.1016/s0950-821x(89)80013-1

9. Gilmont RR, Dardano A, Engle JS, Adamson BS, Welsh MJ, Li T, Remick DG, Smith DJ Jr, Rees RS. TNF-alpha potentiates oxidant and reperfusion-induced endothelial cell injury. J Surg Res. 1996 Feb 15;61(1):175-82. https://doi.org/10.1006/jsre.1996.0101

10. Sears ED, Chung KC. Replantation of finger avulsion injuries: a systematic review of survival and functional outcomes. J Hand Surg Am. 2011 Apr;36(4):686-94. https://doi.org/10.1016/j.jhsa.2010.12.023

11. Chen KT, Mardini S, Chuang DC, Lin CH, Cheng MH, Lin YT, Huang WC, Tsao CK, Wei FC. Timing of presentation of the first signs of vascular compromise dictates the salvage outcome of free flap transfers. Plast Reconstr Surg. 2007 Jul;120(1):187-195. https://doi.org/10.1097/01.prs.0000264077.07779.50

12. Loerakker S, Oomens CW, Manders E, Schakel T, Bader DL, Baaijens FP, Nicolay K, Strijkers GJ. Ischemia-reperfusion injury in rat skeletal muscle assessed with T2-weighted and dynamic contrast-enhanced MRI. Magn Reson Med. 2011 Aug;66(2):528-37. https://doi.org/10.1002/mrm.22801

13. Carmo-Araújo EM, Dal-Pai-Silva M, Dal-Pai V, Cecchini R, Anjos Ferreira AL. Ischaemia and reperfusion effects on skeletal muscle tissue: morphological and histochemical studies. Int J Exp Pathol. 2007 Jun;88(3):147-54. https://doi.org/10.1111/j.1365-2613.2007.00526.x

14. Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery. 1993;14(3):165-75. https://doi.org/10.1002/micr.1920140307

15. Rashid MA, William-Olsson G. Are leukocytosis and lipid peroxidation involved in ischemic or reperfusion injury in cardiac surgery? Thorac Cardiovasc Surg. 1991 Aug;39(4):193-5. https://doi.org/10.1055/s-2007-1022707

16. Lazarus B, Messina A, Barker JE, Hurley JV, Romeo R, Morrison WA, Knight KR. The role of mast cells in ischaemia-reperfusion injury in murine skeletal muscle. J Pathol. 2000 Aug;191(4):443-8. https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH666>3.0.CO;2-L

17. Thaveau F, Zoll J, Bouitbir J, Ribera F, Di Marco P, Chakfe N, Kretz JG, Piquard F, Geny B. Contralateral leg as a control during skeletal muscle ischemia-reperfusion. J Surg Res. 2009 Jul;155(1):65-9. https://doi.org/10.1016/j.jss.2008.08.001

18. Lehr HA, Guhlmann A, Nolte D, Keppler D, Messmer K. Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster. J Clin Invest. 1991 Jun;87(6):2036-41. https://doi.org/10.1172/JCI115233

19. Breda MA, Drinkwater DC, Laks H, Bhuta S, Corno AF, Davtyan HG, Chang P. Prevention of reperfusion injury in the neonatal heart with leukocyte-depleted blood. J Thorac Cardiovasc Surg. 1989 May;97(5):654-65

20. Cetin C, Köse AA, Aral E, Colak O, Erçel C, Karabağli Y, Alataş O, Eker A. Protective effect of fucoidin (a neutrophil rolling inhibitor) on ischemia reperfusion injury: experimental study in rat epigastric island flaps. Ann Plast Surg. 2001 Nov;47(5):540-6. https://doi.org/10.1097/00000637-200111000-00012

21. Siemionow M, Arslan E. Ischemia/reperfusion injury: a review in relation to free tissue transfers. Microsurgery. 2004;24(6):468-75. https://doi.org/10.1002/micr.20060

22. Mittermayr R, Valentini D, Fitzal F, Hallström S, Gasser H, Redl H. Protective effect of a novel NO-donor on ischemia/reperfusion injury in a rat epigastric flap model. Wound Repair Regen. 2003 Jan-Feb;11(1):3-10. https://doi.org/10.1046/j.1524-475x.2003.11103.x

23. Nanobashvili J, Neumayer C, Fuegl A, Punz A, Blumer R, Mittlböck M, Prager M, Polterauer P, Dobrucki LW, Huk I, Malinski T. Combined L-arginine and antioxidative vitamin treatment mollifies ischemia-reperfusion injury of skeletal muscle. J Vasc Surg. 2004 Apr;39(4):868-77. https://doi.org/10.1016/j.jvs.2003.10.060

24. Kuo YR, Wang FS, Jeng SF, Lutz BS, Huang HC, Yang KD. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57(5):1025-31. https://doi.org/10.1097/01.ta.0000100372.92325.32

25. Cordeiro PG, Mastorakos DP, Hu QY, Kirschner RE. The protective effect of L-arginine on ischemia-reperfusion injury in rat skin flaps. Plast Reconstr Surg. 1997 Oct;100(5):1227-33. https://doi.org/10.1097/00006534-199710000-00023

26. Kuo YR, Wang FS, Jeng SF, Lutz BS, Huang HC, Yang KD. Nitrosoglutathione improves blood perfusion and flap survival by suppressing iNOS but protecting eNOS expression in the flap vessels after ischemia/reperfusion injury. Surgery. 2004 Apr;135(4):437-46. https://doi.org/10.1016/j.surg.2003.07.006

27. Lanteri R, Acquaviva R, Di Giacomo C, Caltabiano R, Li Destri G, Vanella L, Santangelo M, Lanzafame S, Di Cataldo A. Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L-arginine. Microsurgery. 2006;26(1):25-32. https://doi.org/10.1002/micr.20206

28. Wautier JL, Setiadi H, Vilette D, Weill D, Wautier MP. Leukocyte adhesion to endothelial cells. Biorheology. 1990;27(3-4):425-32. https://doi.org/10.3233/bir-1990-273-419

29. Olinic DM, Stanek A, Tătaru DA, Homorodean C, Olinic M. Acute Limb Ischemia: An Update on Diagnosis and Management. J Clin Med. 2019 Aug 14;8(8):1215. https://doi.org/10.3390/jcm8081215

30. Ionac M, Schaefer D, Geishauser M. Thromboxane A2 release in ischemia and reperfusion of free flaps in rats, studied by microdialysis. J Reconstr Microsurg. 2001 Feb;17(2):139-43. https://doi.org/10.1055/s-2001-12703

31. Burns AT, Davies DR, McLaren AJ, Cerundolo L, Morris PJ, Fuggle SV. Apoptosis in ischemia/reperfusion injury of human renal allografts. Transplantation. 1998 Oct 15;66(7):872-6. https://doi.org/10.1097/00007890-199810150-00010

32. Jaeschke H. Reperfusion injury after warm ischemia or cold storage of the liver: role of apoptotic cell death. Transplant Proc. 2002 Nov;34(7):2656-8. https://doi.org/10.1016/s0041-1345(02)03464-4

33. Scarabelli TM, Gottlieb RA. Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions. Cell Death Differ. 2004 Dec;11 Suppl 2:S144-52. https://doi.org/10.1038/sj.cdd.4401544

34. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. Transplantation. 1999 Apr 27;67(8):1099-105. https://doi.org/10.1097/00007890-199904270-00003

35. Tatlidede SH, Murphy AD, McCormack MC, Nguyen JT, Eberlin KR, Randolph MA, Moore FD Jr, Austen WG Jr. Improved survival of murine island skin flaps by prevention of reperfusion injury. Plast Reconstr Surg. 2009 May;123(5):1431-1439. https://doi.org/10.1097/PRS.0b013e3181a071e8

36. Iwata A, Morgan-Stevenson V, Schwartz B, Liu L, Tupper J, Zhu X, Harlan J, Winn R. Extracellular BCL2 proteins are danger-associated molecular patterns that reduce tissue damage in murine models of ischemia-reperfusion injury. PLoS One. 2010 Feb 8;5(2):e9103. https://doi.org/10.1371/journal.pone.0009103

37. Crawford RS, Albadawi H, Atkins MD, Jones JJ, Conrad MF, Austen WG Jr, Fink MP, Watkins MT. Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion. J Trauma. 2011 Jan;70(1):103-10; discussion 110. https://doi.org/10.1097/TA.0b013e3182031ccb

38. Lakyová L, Toporcer T, Tomečková V, Sabo J, Radoňak J. Low-level laser therapy for protection against skeletal muscle damage after ischemia-reperfusion injury in rat hindlimbs. Lasers Surg Med. 2010 Nov;42(9):665-72. https://doi.org/10.1002/lsm.20967

39. Henderson PW, Singh SP, Weinstein AL, Nagineni V, Rafii DC, Kadouch D, Krijgh DD, Spector JA. Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo. Plast Reconstr Surg. 2010 Dec;126(6):1890-1898. https://doi.org/10.1097/PRS.0b013e3181f446bc

40. Crawford RS, Albadawi H, Atkins MD, Jones JE, Yoo HJ, Conrad MF, Austen WG Jr, Watkins MT. Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model. Surgery. 2010 Jul;148(1):110-8. https://doi.org/10.1016/j.surg.2009.12.006

41. Murphy AD, McCormack MC, Bichara DA, Nguyen JT, Randolph MA, Watkins MT, Lee RC, Austen WG Jr. Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model. Plast Reconstr Surg. 2010 Jun;125(6):1651-1660. https://doi.org/10.1097/PRS.0b013e3181ccdbef

42. Ergün Y, Oksüz H, Atli Y, Kilinç M, Darendeli S. Ischemia-reperfusion injury in skeletal muscle: comparison of the effects of subanesthetic doses of ketamine, propofol, and etomidate. J Surg Res. 2010 Mar;159(1):e1-e10. https://doi.org/10.1016/j.jss.2008.07.030

43. Dillon JP, Laing AJ, Cahill RA, O'Brien GC, Street JT, Wang JH, Mc Guinness A, Redmond HP. Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle. J Orthop Res. 2005 Nov;23(6):1454-9. https://doi.org/10.1016/j.orthres.2005.04.009.1100230631. Epub 2005 Jul 1. Erratum in: J Orthop Res. 2006 Mar;24(3):576. Dosage error in article text. PMID: 15994053.

44. Zheng J, Wang R, Zambraski E, Wu D, Jacobson KA, Liang BT. Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3685-91. https://doi.org/10.1152/ajpheart.00819.2007

45. Park JW, Qi WN, Cai Y, Urbaniak JR, Chen LE. Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation. Plast Reconstr Surg. 2007 Dec;120(7):1808-1818. https://doi.org/10.1097/01.prs.0000287245.17319.57

46. Mowlavi A, Neumeister MW, Wilhelmi BJ, Song Y-H, Suchy H, Russell RC. Local hypothermia during early reperfusion protects skeletal muscle from ischemia-reperfusion injury. Plast Reconstr Surg. 2003;111(1):242-50. https://doi.org/10.1097/01.PRS.0000034936.25458.98

47. Sapega AA, Heppenstall RB, Sokolow DP, Graham TJ, Maris JM, Ghosh AK, Chance B, Osterman AL. The bioenergetics of preservation of limbs before replantation. The rationale for intermediate hypothermia. J Bone Joint Surg Am. 1988 Dec;70(10):1500-13

48. Wagh M, Pantazi G, Romeo R, Hurley JV, Morrison WA, Knight KR. Cold storage of rat skeletal muscle free flaps and pre-ischemic perfusion with modified UW solution. Microsurgery. 2000;20(7):343-9. https://doi.org/10.1002/1098-2752 (2000)20:7<343::aid-micr6>3.0.co;2-c

49. Ward R, Souder N, Stahl D, Hunter F, Probe R, Chaput C, Childs E. The role of nitric oxide synthase and heme oxygenase in the protective effect of hypothermia in ischemia-reperfusion injury. J Bone Joint Surg Am. 2009 Nov;91(11):2637-45. https://doi.org/10.2106/JBJS.H.01324

50. Zimiani K, Guarnier FA, Miranda HC, Watanabe MA, Cecchini R. Nitric oxide mediated oxidative stress injury in rat skeletal muscle subjected to ischemia/reperfusion as evaluated by chemiluminescence. Nitric Oxide. 2005 Nov;13(3):196-203. https://doi.org/10.1016/j.niox.2005.07.002

51. Wang WZ, Fang XH, Stephenson LL, Zhang X, Williams SJ, Baynosa RC, Khiabani KT, Zamboni WA. Nitrite attenuates ischemia-reperfusion-induced microcirculatory alterations and mitochondrial dysfunction in the microvasculature of skeletal muscle. Plast Reconstr Surg. 2011 Oct;128(4):279e-287e. https://doi.org/10.1097/PRS.0b013e3182268b9a

52. Yapca OE, Borekci B, Suleyman H. Ischemia-reperfusion damage. Eurasian J Med. 2013 Jun;45(2):126-7. https://doi.org/10.5152/eajm.2013.24

53. Cowled PA, Khanna A, Laws PE, Field JB, Varelias A, Fitridge RA. Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury. J Surg Res. 2007 Aug;141(2):267-76. https://doi.org/10.1016/j.jss.2006.11.021

54. Dillon JP, Laing AJ, Chandler JR, Wang JH, McGuinness A, Redmond HP. Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury. Acta Orthop. 2006 Feb;77(1):27-32. https://doi.org/10.1080/17453670610045669

55. Aeba R, Killinger WA, Keenan RJ, Yousem SA, Hamamoto I, Hardesty RL, Griffith BP. Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model. J Thorac Cardiovasc Surg. 1992 Nov;104(5):1333-9. PMID: 1434715.

56. Gu XP, Xu FT, Jiang Y, Qiu YD, Ding YT. Pyrrolidine dithiocarbamate added to University of Wisconsin solution inhibits reperfusion injury after orthotopic liver transplantation in rats. Ann Clin Lab Sci. 2004 Spring;34(2):187-94

57. Renaud F, Succo E, Alessi MC, Legre R, Juhan-Vague I. Iloprost and salvage of a free flap. Br J Plast Surg. 1996 Jun;49(4):245-8. https://doi.org/10.1016/s0007-1226(96)90060-0

58. Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood. 1993 Dec 1;82(11):3253-8. PMID: 7694675.

59. Thourani VH, Brar SS, Kennedy TP, Thornton LR, Watts JA, Ronson RS, Zhao ZQ, Sturrock AL, Hoidal JR, Vinten-Johansen J. Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury. Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H2084-93. https://doi.org/10.1152/ajpheart.2000.278.6.H2084

60. Dandona P, Qutob T, Hamouda W, Bakri F, Aljada A, Kumbkarni Y. Heparin inhibits reactive oxygen species generation by polymorphonuclear and mononuclear leucocytes. Thromb Res. 1999 Dec 15;96(6):437-43. https://doi.org/10.1016/s0049-3848(99)00132-2

61. Prada FS, Arrunategui G, Alves MC, Ferreira MC, Zumiotti AV. Effect of allopurinol, superoxide-dismutase, and hyperbaric oxygen on flap survival. Microsurgery. 2002;22(8):352-60. https://doi.org/10.1002/micr.10073

62. Wilkins EG, Rees RS, Smith D, Cashmer B, Punch J, Till GO, Smith DJ Jr. Identification of xanthine oxidase activity following reperfusion in human tissue. Ann Plast Surg. 1993 Jul;31(1):60-5. PMID: 8357220.

63. Tangney CC, Hankins JS, Murtaugh MA, Piccione W Jr. Plasma vitamins E and C concentrations of adult patients during cardiopulmonary bypass. J Am Coll Nutr. 1998 Apr;17(2):162-70. https://doi.org/10.1080/07315724.1998.10718742

64. Roth E. The impact of L-arginine-nitric oxide metabolism on ischemia/reperfusion injury. Curr Opin Clin Nutr Metab Care. 1998 Jan;1(1):97-9. https://doi.org/10.1097/00075197-199801000-00016

65. Tran TP, Tu H, Pipinos II, Muelleman RL, Albadawi H, Li YL. Tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal muscles: Involvement of superoxide. Eur J Pharmacol. 2011 Jan 10;650(1):328-34. https://doi.org/10.1016/j.ejphar.2010.10.037

66. Bolcal C, Yildirim V, Doganci S, Sargin M, Aydin A, Eken A, Ozal E, Kuralay E, Demirkilic U, Tatar H. Protective effects of antioxidant medications on limb ischemia reperfusion injury. J Surg Res. 2007 May 15;139(2):274-9. https://doi.org/10.1016/j.jss.2006.10.043

67. Ozyurt H, Ozyurt B, Koca K, Ozgocmen S. Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia-reperfusion-induced oxidative stress. Vascul Pharmacol. 2007 Aug-Sep;47(2-3):108-12. https://doi.org/10.1016/j.vph.2007.04.008

68. Park JW, Qi WN, Cai Y, Zelko I, Liu JQ, Chen LE, Urbaniak JR, Folz RJ. Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouse. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H181-7. https://doi.org/10.1152/ajpheart.00458.2004

69. Kingston R, Kearns S, Kelly C, Murray P. Effects of systemic and regional taurine on skeletal muscle function following ischaemia-reperfusion injury. J Orthop Res. 2005 Mar;23(2):310-4. https://doi.org/10.1016/j.orthres.2004.07.003

70. Atahan E, Ergun Y, Belge Kurutas E, Cetinus E, Guney Ergun U. Ischemia-reperfusion injury in rat skeletal muscle is attenuated by zinc aspartate. J Surg Res. 2007 Jan;137(1):109-16. https://doi.org/10.1016/j.jss.2006.05.036

71. Erkanli K, Kayalar N, Erkanli G, Ercan F, Sener G, Kirali K. Melatonin protects against ischemia/reperfusion injury in skeletal muscle. J Pineal Res. 2005 Oct;39(3):238-42. https://doi.org/10.1111/j.1600-079X.2005.00240.x

72. He J, Khan UZ, Qing L, Wu P, Tang J. Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications. Front Immunol. 2022 Sep 16;13:998952. https://doi.org/10.3389/fimmu.2022.998952

73. Khiabani KT, Bellister SA, Skaggs SS, Stephenson LL, Nataraj C, Wang WZ, Zamboni WA. Reperfusion-induced neutrophil CD18 polarization: effect of hyperbaric oxygen. J Surg Res. 2008 Nov;150(1):11-6. https://doi.org/10.1016/j.jss.2007.12.780

74. Jones SR, Carpin KM, Woodward SM, Khiabani KT, Stephenson LL, Wang WZ, Zamboni WA. Hyperbaric oxygen inhibits ischemia-reperfusion-induced neutrophil CD18 polarization by a nitric oxide mechanism. Plast Reconstr Surg. 2010 Aug;126(2):403-411. https://doi.org/10.1097/PRS.0b013e3181df64a5

75. Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011 Jan;127 Suppl 1(Suppl 1):131S-141S. https://doi.org/10.1097/PRS.0b013e3181fbe2bf

76. Mounsey RA, Pang CY, Forrest C. Preconditioning: a new technique for improved muscle flap survival. Otolaryngol Head Neck Surg. 1992 Oct;107(4):549-52. https://doi.org/10.1177/019459989210700406

77. Restifo RJ, Thomson JG. The preconditioned TRAM flap: preliminary clinical experience. Ann Plast Surg. 1998 Oct;41(4):343-7. https://doi.org/10.1097/00000637-199810000-00001

78. Cheng MH, Chen HC, Wei FC, See LC, Lee HY, Wang CJ. Combined ischemic preconditioning and laser Doppler measurement for early division of pedicled groin flap. J Trauma. 1999 Jul;47(1):89-95. https://doi.org/10.1097/00005373-199907000-00020

79. Huang SS, Wei FC, Hung LM. Ischemic preconditioning attenuates postischemic leukocyte--endothelial cell interactions: role of nitric oxide and protein kinase C. Circ J. 2006 Aug;70(8):1070-5. https://doi.org/10.1253/circj.70.1070

80. Vignaud A, Hourde C, Medja F, Agbulut O, Butler-Browne G, Ferry A. Impaired skeletal muscle repair after ischemia-reperfusion injury in mice. J Biomed Biotechnol. 2010;2010:724914. https://doi.org/10.1155/2010/724914

81. Tsubota H, Marui A, Esaki J, Bir SC, Ikeda T, Sakata R. Remote postconditioning may attenuate ischaemia-reperfusion injury in the murine hindlimb through adenosine receptor activation. Eur J Vasc Endovasc Surg. 2010 Dec;40(6):804-9. https://doi.org/10.1016/j.ejvs.2010.08.014

82. Pradka SP, Ong YS, Zhang Y, Davis SJ, Baccarani A, Messmer C, Fields TA, Erdmann D, Klitzman B, Levin LS. Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. Transplant Proc. 2009 Mar;41(2):531-6. https://doi.org/10.1016/j.transproceed.2009.01.021

83. Mamedova LK, Wang R, Besada P, Liang BT, Jacobson KA. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008 Sep-Oct;58(3-4):232-9. https://doi.org/10.1016/j.phrs.2008.08.004

84. Dillon JP, Laing AJ, Chandler JR, Shields CJ, Wang JH, McGuinness A, Redmond HP. Hypertonic saline reduces skeletal muscle injury and associated remote organ injury following ischemia reperfusion injury. Acta Orthop. 2008 Oct;79(5):703-7. https://doi.org/10.1080/17453670810016740

85. McAllister SE, Moses MA, Jindal K, Ashrafpour H, Cahoon NJ, Huang N, Neligan PC, Forrest CR, Lipa JE, Pang CY. Na+/H+ exchange inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion. J Appl Physiol (1985). 2009 Jan;106(1):20-8. https://doi.org/10.1152/japplphysiol.91069.2008

86. Karaaslan O, Ulusoy MG, Kankaya Y, Tiftikcioglu YO, Kocer U, Kankaya D, Karaaslan GM, Tuncer S, Berktas M. Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastricflap model. J Plast Reconstr Aesthet Surg. 2010 Apr;63(4):705-10. https://doi.org/10.1016/j.bjps.2009.01.018

87. Eichhorn W, Blake FA, Pohlenz P, Gehrke G, Schmelzle R, Heiland M. Conditioning of myocutaneous flaps. J Craniomaxillofac Surg. 2009 Jun;37(4):196-200. https://doi.org/10.1016/j.jcms.2008.11.014. Epub 2009 Jan 13

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