Antiphospholipid syndrome and adrenal gland necrosis, report of two cases and review of the literature
Published
Jan 27, 2011
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Abstract
Antiphospholipid syndrome is a disease that can manifest alone or associated with other conditions. Adrenal glands involvement is a rare presentation. There are few cases reported in the literature. We present two cases of patients with antiphospholipid syndrome that compromise the adrenal glands and behave very odd comparing to previous case reports.
Keywords
antiphospholipid syndrome, Addison´s disease, necrosis, síndrome antifosfolípido, enfermedad de Addison, necrosis,
References
1. Arlt W, Allolio B. Adrenal insufficiency. Lancet. 2003;361:1881-93.
2. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Autoimmune adrenal
insufficiency and autoimmune polyendocrine syndromes: Autoantibodies,
autoantigens, and their applicability in diagnosis and disease prediction.
Endocr Rev. 2002;23:327-64.
3. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Eng J Med. 2002;346:752-63.
4. Asherson RA, Cervera R, Piette JC, Shoenfeld Y, Espinosa G, Petri MA et al. Catastrophic antiphospholipid syndrome. Clues to the pathogenesis from a series of 80 patients. Medicine (Baltimore). 2001;80:355-77.
5. Fujishima N, Komatsuda A, Ohyagi H, Fujishima M, Tada M, Ohtani H et al. Adrenal insufficiency complicated with antiphospholipid syndrome. Intern Med. 2006;45:963-6.
6. Böber E, Kovanlikaya A, Büyükgebiz. Primary antiphospholipid síndrome: An unusual cause of adrenal insufficiency. Horm Res. 2001;56:140-4.
7. Carette S, Jobin F. Acute adrenal insufficiency as a manifestation of the anticardiolipin syndrome. Ann Rheum Dis. 1989;48:430-1.
8. Espinosa G, Cervera R, Font J, Asherson RA. Adrenal involvement in the antiphospholipid syndrome. Lupus. 2003;12:569-72.
9. Takebayashi K, Aso Y, Tayama K, Takemura Y, Inukai T. Primary
antiphospholipid syndrome associated with acute adrenal failure. Am J Med Sci. 2003;325:41-4.
10. Ishizuka T. Adrenal insufficiency complicated with antiphospholipid
syndrome. Intern Med. 2006;45:1077-8.
11. Alfadhli E. Secondary adrenal insufficiency and primary antiphospholipid syndrome. Intern Med. 2009;48:1963-6.
12. Asherson R, Hughes G. Addison´s disease and primary antiphosphlipid syndrome. Lancet. 1989;ii:874.
13. Presotto F, Fornasini F, Betterle1 C, Federspil G, Rossato M. Acute adrenal failure as the heralding symptom of primary antiphospholipid syndrome: Report of a case and review of the literature. European Journal of Endocrinology. 2005;153:507-14.
14. Italian Registry of antiphospholipid síndrome (idiopathic and secondary to SLE): first report from the Italian registry. Haematologica. 1993;78:313-8.
2. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Autoimmune adrenal
insufficiency and autoimmune polyendocrine syndromes: Autoantibodies,
autoantigens, and their applicability in diagnosis and disease prediction.
Endocr Rev. 2002;23:327-64.
3. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Eng J Med. 2002;346:752-63.
4. Asherson RA, Cervera R, Piette JC, Shoenfeld Y, Espinosa G, Petri MA et al. Catastrophic antiphospholipid syndrome. Clues to the pathogenesis from a series of 80 patients. Medicine (Baltimore). 2001;80:355-77.
5. Fujishima N, Komatsuda A, Ohyagi H, Fujishima M, Tada M, Ohtani H et al. Adrenal insufficiency complicated with antiphospholipid syndrome. Intern Med. 2006;45:963-6.
6. Böber E, Kovanlikaya A, Büyükgebiz. Primary antiphospholipid síndrome: An unusual cause of adrenal insufficiency. Horm Res. 2001;56:140-4.
7. Carette S, Jobin F. Acute adrenal insufficiency as a manifestation of the anticardiolipin syndrome. Ann Rheum Dis. 1989;48:430-1.
8. Espinosa G, Cervera R, Font J, Asherson RA. Adrenal involvement in the antiphospholipid syndrome. Lupus. 2003;12:569-72.
9. Takebayashi K, Aso Y, Tayama K, Takemura Y, Inukai T. Primary
antiphospholipid syndrome associated with acute adrenal failure. Am J Med Sci. 2003;325:41-4.
10. Ishizuka T. Adrenal insufficiency complicated with antiphospholipid
syndrome. Intern Med. 2006;45:1077-8.
11. Alfadhli E. Secondary adrenal insufficiency and primary antiphospholipid syndrome. Intern Med. 2009;48:1963-6.
12. Asherson R, Hughes G. Addison´s disease and primary antiphosphlipid syndrome. Lancet. 1989;ii:874.
13. Presotto F, Fornasini F, Betterle1 C, Federspil G, Rossato M. Acute adrenal failure as the heralding symptom of primary antiphospholipid syndrome: Report of a case and review of the literature. European Journal of Endocrinology. 2005;153:507-14.
14. Italian Registry of antiphospholipid síndrome (idiopathic and secondary to SLE): first report from the Italian registry. Haematologica. 1993;78:313-8.
How to Cite
Fernández Bonilla, J. N., Jaramillo García, L. F., & Escalante, P. (2011). Antiphospholipid syndrome and adrenal gland necrosis, report of two cases and review of the literature. Universitas Medica, 52(2), 219–226. https://doi.org/10.11144/Javeriana.umed52-2.sans
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Section
Case Reports