Keywords
acute cholecystitis
cholecystectomy
How to Cite
Abstract
Acute calculous cholecystitis is the most important cause of cholecystectomies worldwide. We review the physiopathology of the inflammatory process in this organ secondary to biliary tract obstruction, as well as its clinical manifestations, workup, and the treatment it requires.
Eskelinen M, Ikonen J, Lipponen P. Diagnostic approaches in acute cholecystitis: a prospective study of 1333 patients with acute abdominal pain. Theor Surg. 1993;8:15-20.
Telfer S, Fenyo G, Holt PR, de Dombal FT. Acute abdominal pain in patients over 50 years of age. Scand J Gastroenterol. 1988;144:S47-50.
Elwood D. Cholecystitis. Surg Clin N Am. 2008;88:1241-52.
Indar AA, Beckinham IJ. Acute cholecystitis. BMJ. 2002;325:639-43.
Gracie WA, Ransohoff DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J
Med. 1982;307:798-800.
McSherry CK, Ferstenberg H, Calhoun WF, Lahman E, Virshup M. The natural history of diagnosed gallstone disease
in symptomatic and asymptomatic patients. Ann Surg. 1985;202:59-63.
Friedman GD, Raviola CA, Fireman B. Prognosis of gallstones with mild or no symptoms: 25 years of follow-up in a health maintenance organization. J Clin Epidemiol. 1989;42:127-36.
Gurusamy KS, Samraj K. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Cochrane Database
Syst Rev. 2006;4:CD005440.
Carter HR, Cox RL, Polk HC Jr. Operative therapy for cholecystitis and cholelithiasis: trends over three decades.
Am Surg. 1987;53:565-8.
Urbach DR, Stukel TA. Rate of elective cholecystectomy and the incidence of severe gallstone disease. CMAJ. 2005;172:1015-9.
Strasberg SM. Acute calculous cholecystitis. N Engl J Med. 2008;358:2804-11.
Yeatman TJ. Emphysematous cholecystitis: an insidious variant of acute cholecystitis. Am J Emerg Med. 1986;4:163-6.
Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999;117: 632-9.
Friedman GD, Kannel WB, Dawber TR. The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis. 1966;19:273-92.
Erlinger S. Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol. 2000;12:1347-52.
Liddle RA, Goldstein RB, Saxton J. Gallstone formation during weight-reduction dieting. Arch Intern Med. 1989;149:1750-3.
Everhart JE. Contributions of obesity and weight loss to gallstone disease. Ann Intern Med. 1993;119:1029-35.
Mun EC, Blackburn GL, Matthews JB. Current status of medical and surgical therapy for obesity. Gastroenterol.
;120:669-81.
Cooper J, Geizerova H, Oliver MF. Letter: Clofibrate and gallstones. Lancet. 1975;1:1083.
Porter JB, Jick H, Dinan BJ. Acute cholecystitis and thiazides. N Engl J Med. 1981;304:954-5.
Michielsen PP, Fierens H, van Maercke YM. Drug-induced gallbladder disease. In317 Univ. Méd. Bogotá (Colombia), 51 (3): 301-319, julio-septiembre, 2010 cidence, aetiology and management. Drug Saf. 1992;7:32-45.
Royal College of General Practitioners’ oral contraception study. Oral contraceptives and gallbladder disease. Lancet.
;2:957-9.
Roslyn JJ, DenBesten L, Thompson JE Jr, Silverman BF. Roles of lithogenic bile and cystic duct occlusion in the
pathogenesis of acute cholecystitis. Am J Surg. 1980;140:126-30.
Horton JD, Bilhartz LE. Gallstone disease and its complications. En: Feldman M, editor. Feldman: Sleisenger and
Fordtran’s gastrointestinal and liver disease. Philadelphia, PA: WB Saunders; 2002;1065-90.
Indar AA, Beckingham IJ. Acute cholecystitis. BMJ. 2002;325:639-43
Yusoff IF, Barkun JS, Barkun AN. Diagnosis and management of cholecystitis and cholangitis. Gastroenterol
Clin North Am. 2003;32:1145-68.
Kimura Y, Takada T, Kawarada Y. Definitions, pathophysiology, and epidemiology of acute cholangitis and
cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg. 2007; 14:15-26.
Järvinen H, Renkonen OV, Palmu A. Antibiotics in acute cholecystitis. Ann Clin Res. 1978;10:247-51.
Claesson B, Holmlund D, Mätzsch T. Biliary microflora in acute cholecystitis and the clinical implications. Acta
Chir Scand. 1984;150:229-37.
Bjorvatn B. Cholecystitis –etiology and treatment– microbiological aspects. Scand J Gastroenterol Suppl. 1984;90:65-70.
Watson JF. The role of bacterial infection in acute cholecystitis: a prospective clinical study. Mil Med. 1969;134:
-26.
Singer AJ, McCracken G, Henry MC, Thode HC JR, Cabahug CJ. Correlation among clinical, laboratory, and hepatobiliary scanning finding in patients with suspected acute cholecystitis. Ann Emerg Med. 1996;28:267-72.
Trowbridge RL, Rutkowski NK, Shojania KG. Does this patient have acute cholecystitis? JAMA. 2003;289: 80-6.
Parker LJ, Bukov LF, Wollan PC. Emergency department evaluation of geriatric patients with acute cholecystitis. Acad Emerg Med. 1997;4:51-5.
Urbano FL, Carrol MB. Murphy’s sign. Hospital Physician. 2000;70:51-2.
Zatuchni J. Notes on physical diagnosis. Philadelphia, PA: FA Davis Co; 1964.
Sapira JD. The art and science of bedside diagnosis. Baltimore, MD: Urban & Schwartzenberg Inc. 1990.
Gunn A, Keddie N. Some clinical observations on patients with gallstones. Lancet. 1972;2:230-41.
Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJC, Baron EJ, et al. Diagnosis and management of
complicated intra-abdominal infection in adults and children: Guidelines by the Surgical Infection Society and the
Infectious Diseases Society of America. Clin Infect Dis. 2010;50:133-64.
Ralls PW, Halls J, Lapin SA, Quinn ML, Morris UL, Boswell W. Prospective evaluation of the sonographic Murphy sign in suspected acute cholecystitis. J Clin Ultrasound. 1982;10:113-5.
Bree RL. Further observations on the usefulness of the sonographic Murphy Angarita F. A., Acuña S. A., Jiménez C., Garay J., Gómez D., Domínguez L. C., Colecistitis calculosa aguda sign in the evaluation of suspected acute cholecystitis. J Clin Ultrasound. 1995;23:169-72.
Hanbidge AE, Buckler PM, O’Malley ME, Wilson SR. From the RSNA refresher courses: imaging evaluation for acute pain in the right upper quadrant. Radiographics. 2004;24:1117-35.
Ralls PW, Coletti PM, Halls JM, Siemsen JK. Prospective evaluation of 99m TC-IDA cholescintigraphy in the diagnosis of acute cholecystitis. Radiology. 1982;144:369-71.
Hirota M, Takada T, Kawarada Y, Nimura Y, Miura F, Hirata K, et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg.
;14:78-82.
Kumar A, Deed JS, Bhasin B, Kumar A, Thomas S. Comparison of the effect of diclofenac with hyoscine-Nbutylbromide in the symptomatic treatment of acute biliary colic. ANZ J Surg. 2004;74:573-6.
Akriviadis EA, Hatzigavriel M, Kapnias D, Kirimlidis J, Markantas A, Garyfallos A. Treatment of biliary colic with diclofenac: a randomized, doubleblind, placebo-controlled study. Gastroenterology. 1997;113:225-31.
Fukunaga FH. Gallbladder bacteriology, histology and gallstones: study of unselected cholecystetomy specimens
in Honolulu. Arch. 1979;169:106-10.
Lou MA, Mandal AK, Alexander JL, Thadepalli H. Bacteriology of the human biliary tract and the duodenum.
Arch Surg. 1997;965-7.
Bateson MC. Fortnightly review: gallbladder disease. BMJ. 1999;318:1745-8.
Calpena Rico R, Sánchez Llinares JR, Candela Polo F, Pérez Vázquez MT, Vázquez Rojas JL, Diego Estévez M,
et al. Bacteriologic findings as a prognostic factor in the course of acute cholecystitis. Rev Esp Enferm Apar Dig. 1989;76:465-70.
Kanafani ZA, Khalife N, Kanj SS, Araj GF, Khalifeh M, Sharara AI. Antibiotic use in acute cholecystitis: practice patterns in the absence of evidence-based guidelines. J Infect. 2005;51:128-34.
Lau WY, Yuen WK, Chu KW, Chon KK, Li AK. Systemic antibiotic regimens for acute cholecystitis treated by
early cholecystectomy. Aust NZJ Surg. 1990;60:539-43.
Lewis RT, Allan CM, Goodall RG, Marien B, park M, Lloyd-Smith W, et al. A single preoperative dose of cefazolin prevents postoperative sepsis in high-risk biliary surgery. Can J Surg. 1984;27:44-7.
Yoshida M, Takada T, Kawarada Y, Tanaka A, Nimura Y, Gomi H et al. Antimicrobial therapy for acute cholecystitis:
Tokyo Guidelines. J Hepatobiliary Pancreat Surg. 2007;14:83-90.
Cushieri A, Dubois F, Mouiel J, Mouret P, Becker H, Buess G, et al. The European experience with laparoscopic cholecystectomy. Am J Surg. 1991; 161:385-7.
Yamashita Y, Takada T, Kawarada Y, Nimura Y, Hirota M, Miura F, et al. Surgical treatment of patients with acute cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg.
;14:91-7.
Bittner R. The standard of laparoscopic cholecystectomy. Langenbecks Arch Surg. 2004;389:157-63.
Fialkowski E, Halpin V, Whinney RR. Acute cholecystitis Clin Evid (Online) 2008;pii:0411. Univ. Méd. Bogotá (Colombia), 51 (3): 301-319, julio-septiembre, 2010
Senapati PSP, Bhattarcharya D, Harinath G, Ammori BJ. A survey of the timing and approach to the surgical management of cholelithiasis in patients with acute biliary pancreatitis and acute cholecystitis in the UK. Ann R Coll
Surg Engl. 2003;85:306-12.
Cameron IC, Chadwick C, Phillips J, Johnson AG. Management of acute cholecystitis in UK hospitals: time for
a charge. Postgrad Med J. 2004; 80:292-4.
McCloy R, Randall D, Schug SA, Kehlet H, Simanski C, Bonnet F, et al. Is smaller necessarily better? A systematic
review comparing the effects of minilaparoscopic and conventional laparoscopic cholecystectomy on patient
outcomes. Surg Endosc. 2008; 22:2541-53.
Russell JC, Walsh SJ, Mattie AS, Lyncht JT. Bile duct injuries, 1989-1993: a statewide experience: Connecticut
Laparoscopic Cholecystectomy Registry. Arch Surg. 1996;131:382-8.
Chandler CF, Lane JS, Ferguson P, Thompson JE, Ashley SW. Prospective evaluation of early versus delayed
laparoscopic cholecystectomy for treatment of acute cholecystitis. Am Surg. 2000;66:896-900.
Siddiqui T, MacDonald A, Chong PS, Jenkins JT. Early versus delayed laparoscopic cholecystectomy for acute
cholecystitis: a meta-analysis of randomized clinical trials. Am J Surg. 2008;195:40-7.
Peng WK, Sheikh Z, Nixon SJ, Paterson- Brown S. Role of laparoscopic cholecystectomy in the early management
of acute gallbladder disease. Br J Surg. 2005;92:582-91.
Lo C, Liu C, Fan ST, Lai EC, Wong J. Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Ann Surg. 1998;227:461-7.
Richardson MC, Bell G, Fullarton GM. Incidence and nature of bile duct injuries following laparoscopic cholecystectomy;
an audit of 5,913 cases. West of Scotland Laparoscopic Cholecysctomy Audit Group. Br J Surg. 1996; 83:1356-60.
Brodsky A, Matter I, Sabo E, Cohen A, Abrahamson J, Eldar S. Laparoscopic cholecystectomy for acute cholecystitis:
can the need for conversion and the probability of complications be predicted? Surg Endosc. 2000;14:755-60.
Kama NA, Doganay M, Dolapci E, Reis E, Atli M, Kologlu M. Risk factors resulting in conversion of laparoscopic cholecystectomy to open surgery. Surg Endosc. 2001;15:965-8.
Eldar S, Sabo E, Nash E, Abrahamson J, Matter I. Laparoscopic cholecystectomy for acute cholecystitis: prospective trial. World J Surg. 1997;21:540-5.
Johansson M, Thune A, Blomqvist A, Nelvin L, Lundell L. Impact of choice on therapeutic strategy on patient’s
health-related quality of life. Results of a randomized, controlled clinical trial. Dig Surg. 2204;21:359-62.
Papi C, Catarci M, D’Amborsio L, Gili L, Koch M, Grassi GB, et al. Timing of cholecystectomy for acute calculous
cholecystitis: a meta-analysis. Am J Gastroenterol. 2004;99:147-55.
Shikata S, Noguchi Y, Fukui T. Early versus delayed cholecystectomy for acute cholecystitis: a meta-analysis of
randomized controlled trials. Surg Today. 2005;35:553-60.
Glenn F. Cholecystostomy in the high risk patient with biliary tract disease. Ann Surg. 1977;185:185-91.
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