Análisis de marcadores STR sobre el cromosoma X en una población de Bogotá
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jun 16, 2010
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Resumen
El análisis de marcadores del cromosoma X ha sido ampliamente usado en el área de la genética clínica, particularmente, para el análisis molecular de enfermedades ligadas al X. Recientemente, se han reconocido muchas repeticiones cortas en tándem (Short Tandem Repeats, STR) sobre este cromosoma, por su importancia en análisis forense y de paternidad. Los marcadores gonosómicos son especialmente eficientes para resolver casos difíciles, ya que las probabilidades de exclusión media son mayores que con los marcadores STR autosómicos.
Keywords
frecuencias alélicas, marcadores, STR, cromosoma X, Bogotá, Colombia,
References
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2. Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at fice trimeric and tetrameric tandem repeat loci in four human population groups. Genomics. 1992;
12:241-53.
3. Desmarais D, Zhong Y, Chakraborty R, Perreault C, Busque L. Development of a highly polymorphic STR marker for identity testing purposes at the human androgen receptor gene (HUMARA). J Forensic Sci. 1998;43:1046-9.
4. Moreno MA, Builes JJ, Jaramillo P, Espinal C, Aguirre D, Bravo ML. Allele frequency distribution of five X- chromosomal STRS loci in an Antioquian population sample (Colombia). J Foresic Sci. 2005;50:1-2.
5. Builes JJ, Martínez RE, Espinal C, Aguirre D, Bravo ML, Gusmão L. Allele distribution of three X chromosome STR loci in an Antioquian population sample. Forensic Sci Int. Genetics
supplement Series. 2008;1:140-1.
6. Nei M. Molecular evolutionary genetics. New York: Columbia University Press; 1987.
7. Turrina S, Atzei R, Filippini G, De Leo D. Development and forensic validation of a new multiplex PCR assay with 12 X-chromosomal short tandem repeats. Forensic Sci Int Gen. 2007; 1:201-4.
8. Ribeiro EM, Neves FP, Hutz MH, Brabo TJ; Campos AK, Batista AE. A multiplex PCR for 11 X chromosome STR markers and population data from a Brazilian Amazon Region. Forensic Sci Int Gen. 2008;2:154-8.
9. Tariq MA, Ullad O, Amer R, Sheikh R. Allele frequency distribution of 13 Xchomosomal STR loci in Pakistani population. Int J Legal Med. 2008; 122:525-8.
10. Pereira R, Gómez I, Amorim A, Gusmão L. Genetic diversity of 10 X chromosome STRs in northern Portugal. Int J
Legal Med. 2007;121:192-7.
11. Qui-ling L, De-jian LV, Xiang-Lin W, Hong-yu S, Xin-yao W, et al. Development of a five ChX STRs loci typing system. Int J Legal Med. 2008;122: 261-5.
2. Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at fice trimeric and tetrameric tandem repeat loci in four human population groups. Genomics. 1992;
12:241-53.
3. Desmarais D, Zhong Y, Chakraborty R, Perreault C, Busque L. Development of a highly polymorphic STR marker for identity testing purposes at the human androgen receptor gene (HUMARA). J Forensic Sci. 1998;43:1046-9.
4. Moreno MA, Builes JJ, Jaramillo P, Espinal C, Aguirre D, Bravo ML. Allele frequency distribution of five X- chromosomal STRS loci in an Antioquian population sample (Colombia). J Foresic Sci. 2005;50:1-2.
5. Builes JJ, Martínez RE, Espinal C, Aguirre D, Bravo ML, Gusmão L. Allele distribution of three X chromosome STR loci in an Antioquian population sample. Forensic Sci Int. Genetics
supplement Series. 2008;1:140-1.
6. Nei M. Molecular evolutionary genetics. New York: Columbia University Press; 1987.
7. Turrina S, Atzei R, Filippini G, De Leo D. Development and forensic validation of a new multiplex PCR assay with 12 X-chromosomal short tandem repeats. Forensic Sci Int Gen. 2007; 1:201-4.
8. Ribeiro EM, Neves FP, Hutz MH, Brabo TJ; Campos AK, Batista AE. A multiplex PCR for 11 X chromosome STR markers and population data from a Brazilian Amazon Region. Forensic Sci Int Gen. 2008;2:154-8.
9. Tariq MA, Ullad O, Amer R, Sheikh R. Allele frequency distribution of 13 Xchomosomal STR loci in Pakistani population. Int J Legal Med. 2008; 122:525-8.
10. Pereira R, Gómez I, Amorim A, Gusmão L. Genetic diversity of 10 X chromosome STRs in northern Portugal. Int J
Legal Med. 2007;121:192-7.
11. Qui-ling L, De-jian LV, Xiang-Lin W, Hong-yu S, Xin-yao W, et al. Development of a five ChX STRs loci typing system. Int J Legal Med. 2008;122: 261-5.
Cómo citar
Fuentes, L. M., Sánchez, D. L., Gómez, Y. M., Restrepo, C. M., Gutiérrez, A., & Fonseca, D. J. (2010). Análisis de marcadores STR sobre el cromosoma X en una población de Bogotá. Universitas Medica, 51(3), 284–289. https://doi.org/10.11144/Javeriana.umed51-3.amss
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