Linfocitopenia T CD4+ idiopática: reporte de caso
PDF (Espanhol)
XML JATS (Espanhol)

Palavras-chave

linfocitopenia T CD4 idiopática
linfopenia
infecciones oportunistas
seronegatividad para VIH

Como Citar

Linfocitopenia T CD4+ idiopática: reporte de caso. (2017). Universitas Medica, 57(4), 502-507. https://doi.org/10.11144/Javeriana.umed57-4.ltci
Almetrics
 
Dimensions
 

Google Scholar
 
Search GoogleScholar

Resumo

Este artículo presenta el caso de un hombre mayor que ingresó con cuatro meses de evolución de hemiparesia izquierda progresiva con sospecha de etiología neoplásica. Se le realizó una biopsia cerebral estereotáctica que reveló lesiones granulomatosas con estructuras micóticas intracelulares compatibles con histoplasma. Adicionalmente, el paciente había requerido una orquidectomía debido a una masa testicular con una biopsia que evidenció lesiones granulomatosas. La prueba del VIH y la carga viral fueron negativas, el recuento de linfocitos CD4+ fue inferior a 300 células/µl, y fue positiva la reacción en cadena de la polimerasa para M. tuberculosis en el tejido testicular. Se realizó un nuevo recuento de linfocitos T CD4+ después de seis semanas del diagnóstico que nuevamente fue inferior a 300 células/µl, lo cual confirmó el diagnóstico de linfocitopenia T idiopática de CD4+.

PDF (Espanhol)
XML JATS (Espanhol)

Centers for Disease Control (CDC).

Unexplained CD4+ T-lymphocyte depletion

in persons without evident HIV

infection: United States. MMWR Morb

Mortal Wkly Rep. 1992;41(30):541-45.

Luo L, Li T. Idiopathic CD4 lymphocytopenia

and opportunistic infection: An update.

FEMS Immunol Med Microbiol.

;54:283-9.

Isgrò A, Sirianni MC, Gramiccioni C, et

al. Idiopathic CD4+ lymphocytopenia

may be due to decreased bone marrow

clonogenic capability. Int Arch Allergy

Immunol. 2005;136:379-84.

Netea MG, Brouwer AE, Hoogendoorn

EH, et al. Two patients with cryptococcal

meningitis and idiopathic CD4 lymphopenia:

Defective cytokine production

and reversal by recombinant interferon-γ

therapy. Clin Infect Dis. 2004;39:e83-7.

Salit RB, Hankey KG, Yi R, Rapoport

AP, Mann DL. Detection of CD4(+)

T-cell antibodies in a patient with idiopathic

CD4 T lymphocytopenia and

cryptococcal meningitis. Brit J Haematol.

;139:133-7.

Walker UA, Warnatz K. Idiopathic CD4

lymphocytopenia. Curr Opin Rheumatol.

;18:389-95.

Fantin B, Joly V, Elbim C, et al. Lymphocyte

subset counts during the course

of community-acquired pneumonia:

evolution according to age, human immunodeficiency

virus status, and etiologic

microorganisms. Clin Infect Dis.

;22:1096-8.

Zonios DI, Falloon J, Bennett JE, et al.

Idiopathic CD4+ lymphocytopenia: natural

history and prognostic factors. Blood.

;112:287-94.

Duncan RA, von Reyn CF, Alliegro GM,

Toossi Z, et al. Idiopathic CD4+ lymphocytopenia:

Four patients with opportunistic

infections and no evidence of HIV

infection. N Engl J Med. 1993;328:393-

AIDSinfo. Guidelines for prevention

and treatment of opportunistic infections

in HIV-infected adults and adolescents

[internet]. 2016 [citado 2016 sep 1].

Disponible en: https://aidsinfo.nih.gov/

contentfiles/lvguidelines/AdultOITablesOnly.

pdf

Cunningham-Rundles C, Murray HW,

Smith JP. Treatment of idiopathic CD4

T lymphocytopenia with IL-2. Clin Exp

Immunol. 1999;116:322-5.

Warnatz K, Draeger R, Schleiser M, Peter

HH. Succesful IL-2 therapy for relapsing

herpes zoster infection in a patient with

idiopathic CD4+ T lymphocytopenia.

Immunobiology. 2000;202:204-11.

Moniuszko M, Fry T, Tsai WP, et al. Recombinant

interleukin-7 induces proliferation

of naive macaque CD4+ and CD8+

T cells in vivo. J Virol. 2004;78:9740-9.

Holland SM, Eisenstein EM, Kuhns DB,

Tuner ML et al. Treatment of refractory

disseminated nontuberculous mycobacterial

infection with interferon gamma.

A preliminary report. New Engl J Med.

;330:1348-55.

This journal is registered under a Creative Commons Attribution 4.0 International Public License. Thus, this work may be reproduced, distributed, and publicly shared in digital format, as long as the names of the authors and Pontificia Universidad Javeriana are acknowledged. Others are allowed to quote, adapt, transform, auto-archive, republish, and create based on this material, for any purpose (even commercial ones), provided the authorship is duly acknowledged, a link to the original work is provided, and it is specified if changes have been made. Pontificia Universidad Javeriana does not hold the rights of published works and the authors are solely responsible for the contents of their works; they keep the moral, intellectual, privacy, and publicity rights.

Approving the intervention of the work (review, copy-editing, translation, layout) and the following outreach, are granted through an use license and not through an assignment of rights. This means the journal and Pontificia Universidad Javeriana cannot be held responsible for any ethical malpractice by the authors. As a consequence of the protection granted by the use license, the journal is not required to publish recantations or modify information already published, unless the errata stems from the editorial management process. Publishing contents in this journal does not generate royalties for contributors.