Publicado Oct 29, 2013



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Claudia Patricia Lamby Tovar

Olga Lucia Gómez González

Lorenza María Jaramillo Gómez

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Resumen

La saliva humana es un fluido del cuerpo esencial para la salud y una fuente ideal de biomarcadores para el diagnóstico, especialmente de enfermedades orales. La α-amilasa salival humana (AASH) es la proteína de la saliva que se encuentra en mayor concentración y posee actividad enzimática, ya que cataliza los enlaces α-1,4-glucosídicos de los almidones y los carbohidratos. También desempeña un papel importante en la colonización y metabolismo de las bacterias que conducen a la formación de la placa. En solución, esta proteína se une con gran afinidad a un selecto grupo de estreptococos orales, lo cual puede ayudar en la depuración o limpieza bacteriana de la cavidad oral. Es producida localmente en las glándulas salivales y su secreción es controlada por el sistema nervioso autónomo, por lo cual ha sido propuesta como un biomarcador para la actividad de este sistema. El objetivo de este artículo es analizar la importancia que tiene la AASH en la salud general.

 

Saliva is an important body fluid essential for health. Human saliva is an ideal source in the search of diagnostic markers, especially for oral disease. α-Amylase is a major protein in saliva, which catalyzes hydrolysis of 1,4-α-glucosidic linkages in starch and other polysaccharides. It also plays an important role in the colonization and metabolism of bacteria leading to dental plaque formation. α-Amylase in solution binds with high affinity to a selected group of oral streptococci, a function that may contribute to bacterial clearance. Salivary α-amylase is produced locally in the salivary glands that are controlled by the autonomic nervous system; for these reasons it has been proposed as a marker for stress induced activity of the sympathetic nervous system. The aim of this article is to analyze the importance of α-Amylase for general health.

Keywords
References
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Cómo citar
Lamby Tovar, C. P., Gómez González, O. L., & Jaramillo Gómez, L. M. (2013). La α-amilasa salival: relación con la caries dental y la salud en general / Salivary α-Amylase: Relation with Dental Caries and Health in General. Universitas Odontologica, 32(69), 93–101. Recuperado a partir de https://revistas.javeriana.edu.co/index.php/revUnivOdontologica/article/view/SICI%3A%202027-3444%28201307%2932%3A69%3C93%3AASCDSG%3E2.0.CO%3B2-X
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