Recurrencia del carcinoma escamocelular de cavidad oral en pacientes del Centro Javeriano de Oncología, Bogotá Colombia, en el periodo 2000-2012 / Oral Squamous Cell Carcinoma Recurrence in Patients from the Centro Javeriano de Oncologia, Bogota Colombia
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Antecedentes: en la patología oral tumoral, las neoplasias malignas de cavidad oral, especialmente el carcinoma escamocelular, son lesiones que se presentan con cierta frecuencia. En Colombia se encuentran pocos estudios publicados en la literatura sobre la recurrencia de esta patología. Propósito: describir la recurrencia del carcinoma escamocelular de cavidad oral reportada en las historias clínicas de pacientes adultos. Métodos: se realizó un estudio retrospectivo descriptivo en el que se analizaron las historias clínicas de pacientes adultos del Centro Javeriano de Oncología del Hospital Universitario de San Ignacio de la Pontificia Universidad Javeriana, Bogotá, Colombia, quienes fueron diagnosticados con carcinoma escamocelular de cavidad oral entre 2000 y 2012. Se analizaron las variables sexo, edad, localización, tratamiento, recurrencia, tiempo de recurrencia, afectación ganglionar, metástasis y hábito de tabaquismo. Los datos fueron tabulados en una matriz y cada variable se estudió con medidas de frecuencia absolutas y relativas para determinar tendencias. Resultados: la recurrencia del carcinoma escamocelular de cavidad oral se presentó más en el sexo femenino. La recurrencia se evidenció más frecuentemente en la lengua y en pacientes fumadores.
Background: In oral pathology, malignant neoplasms, particularly oral squamous cell carcinoma (OSCC), are prevalent pathologies. There are not many studies published about the recurrence of OSCC in Colombia. Purpose: To describe the recurrence of OSCC reported in clinical records among adult patients Methods: A retrospective study in which clinical records of adult patients attending the Javeriana University Oncology Center in Bogota Colombia were analyzed. Patients were diagnosed with OSCC between 2000 and 2012. Frequency of variables such as gender, age, location, treatment, recurrence, time to recurrence, lymph node, metastasis, and smoking habits was described, in order to determine trends. Results: OSCC recurrence was more frequent among females, in tongue, and among smokers.
2. Hirota SK, Migliari DA, Sugaya NN. Oral squamous cell carcinoma in a young patient: Case report and literature review. Anais Bras Dermatol. 2006; 81(3): 251-4.
3. Epstein BJ, Zhang L, Rosin M. Advances in the diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc. 2002; 68: 617-21.
4. Jainkittivong A, Swasdison S Thangpisityotin M, Langlais RP. Oral squamous cell carcinoma: a clinic pathological study of 342 Thai cases. J Contemp Dent Pract. 2009 Sep 1; 10(5): E033-40.
5. Alsharif MJ, Jiang WA, He S, Zhao Y, Shan Z, Chen X. Gingival squamous cell carcinoma in young patients: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107(5): 696-700.
6. Hsieh TY, Chang KP, Lee SS, Chang CH, Lai CH, Wu YC, Huang SH, Lai CS, Lin SD. Free flap reconstruction in patients with advanced oral squamous cell carcinoma: Analysis of patient survival and cancer recurrence. Microsurgery. 2012 Nov; 32(8): 598-604.
7. Piao S, Liu Y, Hu J, Guo F, Ma J, Sun Y, Zhang B. USP22 is useful as a novel molecular marker for predicting disease progression and patient prognosis of oral squamous cell carcinoma. PLoSOne. 2012; 7(8): e42540.
8. Girardi F, Zanella V, Kroef R. Correlation between clinical and pathological data and surgical margins in patients with squamous cell carcinoma of the oral cavity. Braz J Otorhinolaryngol. 2013 Apr; 79(2): 190-5.
9. Vered M, Dayan D, Dobriyan A, Yahalom R, Shalmon B, Barshack I, Bedrin L, Talmi Y, Taicher S. Oral tongue squamous cell carcinoma: recurrent disease is associated with histopathologic risk score and young age. J Cancer Res Clin Oncol. 2010; 136: 1039-48.
10. Álvarez E, Barbosa M, Gaviria A. Comportamiento clínico-epidemiológico del carcinoma escamocelular bucal de pacientes tratados en el hospital universitario San Vicente de Paul (HUSVP), Medellín, entre enero de 1990 y diciembre de 1996. Rev Fac Odontol Univ Ant. 2005; 16(1 y 2): 26-32.
11. Smee R, Broadley K, Bridger P, Williams J. Floor of mouth carcinoma: surgery still the dominant mode of treatment. J Med Imaging Rad Oncol. 2012; 56: 338-46.
12. Gonzalez R, Naval L, Romero L, Sastre S, Rodriguez F. Local recurrences and second primary tumors from squamous cell carcinoma of the oral cavity: A retrospective analytic study of 500 patients. Head Neck. 2009; 31: 1168-80.
13. Kaminagakura E, Vartanian JE, Da Silva SD, Dos Santos CR, Kowalski L. Case-control study on prognostic factors in oral squamous cell carcinoma in young patients. Head Neck. 2010; 32: 1460-6.
14. Harris S, Kimple R, Hayes N, Couch M, Rosenman J. Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers. Head Neck. 2010; 32: 499-503.
15. Mücke T, Hölzle F, Wagenpfeil S, Wolff CK, Kesting M. The role of tumor invasion into the mandible of oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2011; 137: 165-71.
16. Peña A, Arredondo M, Martínez V. Comportamiento clínico y epidemiológico del cáncer de cavidad oral. Rev Cubana Estomatol. 2006 Mar; 43(1): 1-6.
17. Chih-Hsien L, Han-Ju Ch, Pa-Chun W, Huan-Sen Ch, Yen-Liang Ch. Patterns of recurrence and second primary tumors in oral squamous cell carcinoma treated with surgery alone Kaohsiung J Med Sci. 2013; 29: e554-9.
18. Yen-Bin H, Shyue-Yih Ch, Ming-Chin L, Jui-Lin H,Shyh-Kuan T, Pen-Yuan Ch. Second primary malignancies in squamous cell carcinomas of the tongue and larynx: an analysis of incidence, pattern, and outcome. J Chin Med Assoc. 2008; 71(2): 86-91
19. Mantilla R, Torres F. Análisis de la recurrencia de cáncer de lengua considerando la presencia de eventos competitivos. Rev Med Hered. 2008; 19: 145-51.
20. Brown J, Blackburn T, Woolgar J, Lowe D, Errington R, Vaughan E, Rogers S. A comparison of outcomes for patients with oral squamous cell carcinoma at intermediate risk of recurrence treated by surgery alone or with post-operative radiotherapy. Oral Oncol. 2007; 43: 764-73.
21. Goyanes A, Bosch M, Vicente A. Manual de oncología básica. Madrid: Asociación Española Contra el Cáncer; 2003.