Publicado Aug 10, 2010



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Jorge Mario Rodríguez Fernández

Mary García Acero

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Resumen

En estudios previos se han relacionado las alteraciones funcionales del eje hipotálamohipofisario-adrenal y el estrés temprano; por ejemplo, el aumento en la producción de corticotropina (ACTH) y glucocorticoide como factor clave en la fisiopatología de trastornos del estrés como la depresión.

En este artículo se presentan los resultados de estudios en epigenética en busca del posible nexo entre el estrés temprano, la disminución en la expresión del receptor de glucocorticoide y la hiperactividad del eje hipotálamo-hipofisario-adrenal. De esta manera, se identifica al estrés temprano como modulador del neurodesarrollo de las estructuras cerebrales implicadas en la respuesta frente al estrés, así como el papel del receptor de glucocorticoide en dicho proceso.

Keywords

estrés, depresión, glucocorticoide, desarrollo, stress, depression, system, glucocorticoid, development,

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Cómo citar
Rodríguez Fernández, J. M., & García Acero, M. (2010). El papel del receptor de glucocorticoide en el estrés temprano. Universitas Medica, 51(4), 385–391. https://doi.org/10.11144/Javeriana.umed51-4.pget
Sección
Artículos de revisión