Publicado Apr 23, 2013



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Jorge Mario Rodríguez-Fernández

Mary García-Acero

Pamela Franco

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Resumen

Actualmente existe gran cantidad de información relacionada con el estrés y sus efectos. Por eso, este artículo se enfoca en el efecto de las hormonas del estrés en diversas áreas cerebrales, como lo son estructuras límbicas y en el eje hipotálamo-hipófisis-adrenal. Así mismo, se discutirá cómo el estrés repetitivo lleva a modificaciones en dichas áreas por el efecto de los glucocorticoides, pues dichas hormonas alteran la actividad basal de la amígdala, del hipocampo y de la corteza prefrontal medial, la función del eje hipotálamo-hipófisis-adrenal y funciones cognitivas como la memoria. Sin embargo, el mecanismo mediante el cual se producen dichos cambios es poco comprendido. Por eso, un reto a futuro es ligar los cambios celulares con sus efectos comportamentales, con el fin de entender su relación con el organismo in vivo.

Keywords

Glucocorticoid, stress, memory, depression, glucocorticoide, estrés, memoria, depresión,

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Cómo citar
Rodríguez-Fernández, J. M., García-Acero, M., & Franco, P. (2013). Neurobiología del estrés agudo y crónico: su efecto en el eje hipotálamohipófisis- adrenal y la memoria. Universitas Medica, 54(4), 472–494. https://doi.org/10.11144/Javeriana.umed54-4.neac
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