Trigeminovascular System and Primary Headache
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The pathophysiology of primary headache is complex and it includes several interactions that regulate the nociceptive process. The trigeminal-vascular system is perhaps one of the principal structures that generate pain due to the integration of several pathways both central and peripheral. In addition to this, the trigeminal vascular system also plays a central role in the autonomic and visual symptoms that affect individuals with headache and in the central sensitization process. In this article we briefly discuss the main structures that participate in the pathophysiology of primary headaches and their interactions in the different levels of the central nervous system.
cefalea, síndromes de migraña, cefalea de tipo tensional, cefalea histamínica, fisiopatología, Headache disorders, migraine, tension type headache, cluster headache, pathophysiology,
2. Ray BS, Wolff HG. Experimental studies on headache: Pain sensitive structures of the head and their significance in headache. Arch Surg. 1940;41:813-56.
3. Cutrer FM. Pathophysiology of migraine. Seminars Neurol. 2010;30(2):120-30.
4. Goadsby P. Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurology. 2002;1:251-7.
5. Aguggia M. Neurophysiology of pain. Neurol Sci. 2003;24:S57-60.
6. Akerman S, Holland PR, Goadsby P. Diencephalic and brainstem mechanisms in migraine. Nature. 2011;12:570-83.
7. Messlinger K. Migraine: Where and how does the pain originate? Exp Brain Res. 2009;196(1):179-93.
8. Akerman S, Holland PR, Goadsby PJ. Diencephalic and brainstem mechanisms in migraine. Nat Rev Neurosci. 2011;12(10):570-84.
9. D’Andrea G, Terrazzino S, Fortin D et al. Elusive amines and primary headaches: historical background and prospective.
Neurol Sci. 2003;24:S65-7.
10. Fusco M, D’Andrea G, Miccichè F, Stecca A et al. Neurogenic inflammation in primary headaches. Neurol Sci. 2003;24:S61-4.
11. Noseda R, Burstein R. Advances in understanding the mechanisms of migrainetype photophobia. Curr Opin Neurol.
2011;24:197-202.
12. Strassman AM, Raymond SA, Burstein R. Sensibitization of meningeal sensory neurons and the origin of headaches. Nature. 1996;384:560-4.
13. Benarroch E. Pain-autonomic interactions. Neurol Sci. 2006;27:S130-3.
14. Cortelli P, Pierangeli G. Chronic pain autonomic interactions. Neurol Sci. 2003;24:S68-70.
15. Olesen J, Burstein R, Ashina M, Tfelt-Hansen P. Origin of pain in migraine: evidence for peripheral Sensitixation. Lancet Neurol. 2009;8:679-90.
16. Arbab MA, Wiklund L, Svendgaard NA. Origin and distribution of cerebral vascular innervations from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGAHRP tracing in the rat. Neuroscience. 1986;19:695-708.
17. Colombo B, Annovazzi P, Comi G. Neuropathic cranial pain. Neurol Sci. 2003;24:S132-7.
18. Leone M, Bussone G. Pathophysiology of trigeminal autonomic cephalalgias. Lancet Neurol. 2009;8:755-64.
19. Balasubramaniam R, Klasser D. Trigeminal autonomic cephalalgias. Part 1: cluster headache. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:345-58.
20. Drummond P. Mechanisms of autonomic disturbance in the face during and between attacks of cluster headache. Cephalalgia. 2006;26:633-41.
21. Moschiano F, D’Amico D, Schieroni F, Bussone G. Neurobiology of chronic migraine. Neurol Sci. 2003;24:S94-6.
22. Montagna P. Chronic headache genetics. Neurol Sci. 2003;24:S51-6.