Palavras-chave
arbovirus
recién nacido
embarazo
exposición transplacentaria.
Como Citar
Resumo
El virus de chikunguña es un arbovirus de la familia Togaviridae y fue aislado por primera vez en Tanzania y Uganda, en 1953. Esta infección se ha desarrollado de manera endémica y es transmitida por el mosquito del género Aedes. El mecanismo exacto de la transmisión de madre a hijo aún no se tiene claro, pero se han identificado potenciales complicaciones de la transmisión vertical, como malformaciones congénitas, mortinatos, restricción del crecimiento intrauterino y partos pretérmino. En este artículo se presentan dos casos clínicos de neonatos que presentaron arritmias cardiacas en sus primeros días de vida, hijos de madres con síndrome febril en curso por chikunguña. Se diagnosticó miocarditis por chikunguña y transmisión vertical, confirmado por reacción de cadena de polimerasa. Ambos pacientes recibieron manejo médico, incluidas inmunoglobulinas, con mejoría del cuadro clínico, sin desenlaces fatales.
Lum F-M, Ng LFP. Cellular and molecular
mechanisms of chikungunya
pathogenesis. Antiviral Res [internet].
;120:165-74. Disponibl en: http://
linkinghub.elsevier.com/retrieve/pii/
S0166354215001400
Gérardin P, Barau G, Michault A, Bintner
M, Randrianaivo H, Choker G, et al.
Multidisciplinary prospective study of
mother-to-child chikungunya virus infections
on the island of La Réunion. PLoS
Med. 2008;5(3):0413-23.
Laoprasopwattana K, Suntharasaj T, Petmanee
P, Suddeaugrai O, Geater a. Chikungunya
and dengue virus infections during
pregnancy: seroprevalence, seroincidence
and maternal-fetal transmission, southern
Thailand, 2009-2010. Epidemiol Infect
[Internet]. 2015;1-8. Disponible en: http://
www.journals.cambridge.org/abstract_
S0950268815001065
Gérardin P, Sampériz S, Ramful D, Boumahni
B, Bintner M, Alessandri JL, et al.
Neurocognitive outcome of children exposed
to perinatal mother-to-child chikungunya
virus infection: The CHIMERE Cohort
Study on Reunion Island. PLoS Negl Trop
Dis. 2014;8(7).
Shrivastava A, Waqar Beg M, Gujrati C,
Gopalan N, Rao PVL. Management of a
vertically transmitted neonatal Chikungunya
thrombocytopenia. Indian J Pediatr.
;78(8):1008-9.
Ramful D, Carbonnier M, Pasquet M, Bouhmani
B, Ghazouani J, Noormahomed T, et
al. Mother-to-child transmission of Chikungunya
virus infection. Pediatr Infect Dis J.
;26(9):811-5.
Ramful D, Samperiz S, Fritel X, Michault
a., Jaffar-Bandjee M-C, Rollot O, et al. Antibody
kinetics in infants exposed to chikungunya
virus infection during pregnancy
reveals absence of congenital infection. J
Infect Dis [Internet]. 2014;209(11):1726-
Disponible en: http://jid.oxfordjournals.
org/lookup/doi/10.1093/infdis/jit814
Pollack A, Kontorovich AR, Fuster V,
Dec GW. Viral myocarditis—diagnosis,
treatment options, and current controversies.
Nat Rev Cardiol [Internet]. 2015;1-12.
Disponible en: http://www.nature.com/
doifinder/10.1038/nrcardio.2015.108
Durani Y, Giordano K, Goudie
BW. Myocarditis and pericarditis
in children. Pediatr Clin North Am
[Internet]. 2010;57(6):1281-303. Disponible
en: http://dx.doi.org/10.1016/j.
pcl.2010.09.012
Weaver SC, Lecuit M. Chikungunya virus
and the global spread of a mosquito-borne
disease. N Engl J Med. 2015;372:1231-
doi: 10.1056/NEJMra1406035
Fritel X, Rollot O, Gérardin P, Gaüzère
BA, Bideault J, Lagarde L, et al. Chikungunya
virus infection during pregnancy,
Réunion, France, 2006. Emerg Infect Dis.
;16(3):418-25.
Jaramillo Restrepo BN. Infección por el
virus del chikungunya. Rev CES Med [internet].
;28(2):313-23. Disponible
en: http://www.scielo.org.co/pdf/cesm/
v28n2/v28n2a16.pdf
This journal is registered under a Creative Commons Attribution 4.0 International Public License. Thus, this work may be reproduced, distributed, and publicly shared in digital format, as long as the names of the authors and Pontificia Universidad Javeriana are acknowledged. Others are allowed to quote, adapt, transform, auto-archive, republish, and create based on this material, for any purpose (even commercial ones), provided the authorship is duly acknowledged, a link to the original work is provided, and it is specified if changes have been made. Pontificia Universidad Javeriana does not hold the rights of published works and the authors are solely responsible for the contents of their works; they keep the moral, intellectual, privacy, and publicity rights.
Approving the intervention of the work (review, copy-editing, translation, layout) and the following outreach, are granted through an use license and not through an assignment of rights. This means the journal and Pontificia Universidad Javeriana cannot be held responsible for any ethical malpractice by the authors. As a consequence of the protection granted by the use license, the journal is not required to publish recantations or modify information already published, unless the errata stems from the editorial management process. Publishing contents in this journal does not generate royalties for contributors.