Introduction: The teaching experience of a teachers group for clinical procedures learning, has been done through virtual guides developed by instructional design models in which were taken into acount technological and pedagogical aspects.Objective: Create a virtual in clinical simulation for the autonomous learning procedure of clinical assistance in nursing students through the application of an instructional desing model.Methods: The elaboration of the guide required the application of the instructional design model ADDIE (abbreviations in English that mean the stages of analysis, design, development, implementation and evaluation), on which some qualitative as well as quantitative measurements were executed.Results: The quantitative measurements executed with 159 participants between 2015-2016, indicated an average score of 3.99 with a standard deviation of 0.86, which determined that the strategy used for learning the procedure with virtual guidance was effective. The qualitative measurement assessed dimensions of satisfaction, realistic experience, confidence, motivation, technical skills and decision making, showing that teacher support was still required in the simulation area, which reduced the satisfaction of some participants. Likewise, a factor that was affected was communication because the guidance does not facilitate the development of such ability.It is concluded: the ADDIE instructional design model is useful for the elaboration of virtual guides of clinical procedures and in its final evaluation stage, it allows the implementation of qualitative and quantitative research evaluative processes to verify its effectiveness.